Peter Park

Peter Park, PhD

Professor of Biomedical Informatics
Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street, Boston, MA 02115

Park Lab

Dr. Park is a Professor of Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics PhD program. His research group specializes in computational and statistical analysis of large-scale DNA sequencing data to understand genetic and epigenetic mechanisms related to disease processes. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for genome analysis, especially for identification of structural alterations from whole-genome sequencing data, and has made substantial contributions to consortium projects such as The Cancer Genome Atlas (TCGA), Encyclopedia of DNA Elements (ENCODE), and Brain Somatic Mosaicism Network, and 4D Nucleome (4DN).


DBMI Research Areas
DBMI Courses
The effect of a local anesthetic cocktail in a serratus anterior plane and PECS 1 block for implant-based breast reconstruction.
Authors: Lombana NF, Beard C, Mehta IM, Falola RA, Park P, Altman AM, Saint-Cyr MH.
JPRAS Open
View full abstract on Pubmed
Recent Advances in Genomic Approaches for the Detection of Homologous Recombination Deficiency.
Authors: Kim YN, Gulhan DC, Jin H, Glodzik D, Park PJ.
Cancer Res Treat
View full abstract on Pubmed
High-resolution detection of copy number alterations in single cells with HiScanner.
Authors: Zhao Y, Luquette LJ, Veit AD, Wang X, Xi R, Viswanadham VV, Shao DD, Walsh CA, Yang HW, Johnson MD, Park PJ.
bioRxiv
View full abstract on Pubmed
Contribution of de novo retroelements to birth defects and childhood cancers.
Authors: Chu C, Ljungström V, Tran A, Jin H, Park PJ.
medRxiv
View full abstract on Pubmed
Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes.
Authors: Ganz J, Luquette LJ, Bizzotto S, Miller MB, Zhou Z, Bohrson CL, Jin H, Tran AV, Viswanadham VV, McDonough G, Brown K, Chahine Y, Chhouk B, Galor A, Park PJ, Walsh CA.
Cell
View full abstract on Pubmed
A Panel-Based Mutational Signature of Mismatch Repair Deficiency is Associated With Durable Response to Pembrolizumab in Metastatic Castration-Resistant Prostate Cancer.
Authors: Boiarsky D, Gulhan DC, Savignano H, Lakshminarayanan G, McClure HM, Silver R, Hirsch MS, Sholl LM, Choudhury AD, Ananda G, Park PJ, Tewari AK, Berchuck JE.
Clin Genitourin Cancer
View full abstract on Pubmed
Epigenetic profiling reveals key genes and cis-regulatory networks specific to human parathyroids.
Authors: Jung YL, Zhao W, Li I, Jain D, Epstein CB, Bernstein BE, Parangi S, Sherwood R, Robinson-Cohen C, Hsu YH, Park PJ, Mannstadt M.
Nat Commun
View full abstract on Pubmed
Accurate and sensitive mutational signature analysis with MuSiCal.
Authors: Jin H, Gulhan DC, Geiger B, Ben-Isvy D, Geng D, Ljungström V, Park PJ.
Nat Genet
View full abstract on Pubmed
Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns.
Authors: Watson EV, Lee JJ, Gulhan DC, Melloni GEM, Venev SV, Magesh RY, Frederick A, Chiba K, Wooten EC, Naxerova K, Dekker J, Park PJ, Elledge SJ.
Nat Genet
View full abstract on Pubmed
Comparative Evaluation of Proton Therapy and Volumetric Modulated Arc Therapy for Brachial Plexus Sparing in the Comprehensive Reirradiation of High-Risk Recurrent Breast Cancer.
Authors: Choi JI, McCormick B, Park P, Millar M, Walker K, Tung CC, Huang S, Florio P, Chen CC, Lozano A, Hanlon AL, Fox J, Xu AJ, Zinovoy M, Mueller B, Bakst R, LaPlant Q, Braunstein LZ, Khan AJ, Powell SN, Cahlon O.
Adv Radiat Oncol
View full abstract on Pubmed