Sian Owen

Sian Owen, PhD

Research Fellow in Biomedical Informatics
Baym Lab
Mentor: Michael Baym, PhD

Sian Owen completed her PhD and a short postdoctoral fellowship at the University of Liverpool, UK, in the group of Professor Jay Hinton. Owen's research explored the biological contribution of temperate bacteriophages to an emerging variant of Salmonella enterica serovar Typhimuriumthat is associated with an epidemic of bloodstream infections in sub-Saharan Africa. She is currently working in the Baym Lab in the Department of Biomedical Informatics and the Laboratory of Systems Pharmacology using experimental evolution and computational approaches to study the phenomenon of antibiotic resistance in bacteria.

The bacterial toxin colibactin triggers prophage induction.
Authors: Silpe JE, Wong JWH, Owen SV, Baym M, Balskus EP.
Nature
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Prophages encode phage-defense systems with cognate self-immunity.
Authors: Owen SV, Wenner N, Dulberger CL, Rodwell EV, Bowers-Barnard A, Quinones-Olvera N, Rigden DJ, Rubin EJ, Garner EC, Baym M, Hinton JCD.
Cell Host Microbe
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Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease.
Authors: Preciado-Llanes L, Aulicino A, Canals R, Moynihan PJ, Zhu X, Jambo N, Nyirenda TS, Kadwala I, Sousa Gerós A, Owen SV, Jambo KC, Kumwenda B, Veerapen N, Besra GS, Gordon MA, Hinton JCD, Napolitani G, Salio M, Simmons A.
Proc Natl Acad Sci U S A
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Genetic variation in the MacAB-TolC efflux pump influences pathogenesis of invasive Salmonella isolates from Africa.
Authors: Honeycutt JD, Wenner N, Li Y, Brewer SM, Massis LM, Brubaker SW, Chairatana P, Owen SV, Canals R, Hinton JCD, Monack DM.
PLoS Pathog
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Barcoded microbial system for high-resolution object provenance.
Authors: Qian J, Lu ZX, Mancuso CP, Jhuang HY, Del Carmen Barajas-Ornelas R, Boswell SA, Ramírez-Guadiana FH, Jones V, Sonti A, Sedlack K, Artzi L, Jung G, Arammash M, Pettit ME, Melfi M, Lyon L, Owen SV, Baym M, Khalil AS, Silver PA, Rudner DZ, Springer M.
Science
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A window into lysogeny: revealing temperate phage biology with transcriptomics.
Authors: Owen SV, Canals R, Wenner N, Hammarlöf DL, Kröger C, Hinton JCD.
Microb Genom
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The fitness landscape of the African Salmonella Typhimurium ST313 strain D23580 reveals unique properties of the pBT1 plasmid.
Authors: Canals R, Chaudhuri RR, Steiner RE, Owen SV, Quinones-Olvera N, Gordon MA, Baym M, Ibba M, Hinton JCD.
PLoS Pathog
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The use of chicken and insect infection models to assess the virulence of African Salmonella Typhimurium ST313.
Authors: Lacharme-Lora L, Owen SV, Blundell R, Canals R, Wenner N, Perez-Sepulveda B, Fong WY, Gilroy R, Wigley P, Hinton JCD.
PLoS Negl Trop Dis
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Adding function to the genome of African Salmonella Typhimurium ST313 strain D23580.
Authors: Canals R, Hammarlöf DL, Kröger C, Owen SV, Fong WY, Lacharme-Lora L, Zhu X, Wenner N, Carden SE, Honeycutt J, Monack DM, Kingsley RA, Brownridge P, Chaudhuri RR, Rowe WPM, Predeus AV, Hokamp K, Gordon MA, Hinton JCD.
PLoS Biol
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Role of a single noncoding nucleotide in the evolution of an epidemic African clade of Salmonella.
Authors: Hammarlöf DL, Kröger C, Owen SV, Canals R, Lacharme-Lora L, Wenner N, Schager AE, Wells TJ, Henderson IR, Wigley P, Hokamp K, Feasey NA, Gordon MA, Hinton JCD.
Proc Natl Acad Sci U S A
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