Cheng-Zhong Zhang, Ph.D.
Cheng-Zhong Zhang, Ph.D.
Assistant Professor of Biomedical Informatics
Department of Biomedical Informatics 10 Shattuck Street Room 315B Boston, MA 02115

Cheng-Zhong Zhang obtained a Ph.D. in Chemical Engineering with a minor in Physics from Caltech. He received postdoctoral training in single-molecule biophysics in Timothy Springer’s laboratory at Harvard Medical School and subsequently worked on single-cell genomics and cancer biology in Matthew Meyerson’s laboratory at the Broad Institute of Harvard and MIT and at Dana-Farber Cancer Institute. He combines single-cell genomic analysis and cell biology to study genome evolution and phenotypic variation. Currently he focuses on the mechanisms and the transcriptional consequences of chromosomal abnormalities, such as rearrangement and aneuploidy, and how such events may promote tumor development.


DBMI Research Program
Calibrating genomic and allelic coverage bias in single-cell sequencing.
Authors: Zhang CZ, Adalsteinsson VA, Francis J, Cornils H, Jung J, Maire C, Ligon KL, Meyerson M, Love JC.
Nat Commun
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Chromothripsis: A New Mechanism for Rapid Karyotype Evolution.
Authors: Leibowitz ML, Zhang CZ, Pellman D.
Annu Rev Genet
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From Mutational Mechanisms in Single Cells to Mutational Patterns in Cancer Genomes.
Authors: Zhang CZ, Pellman D.
Cold Spring Harb Symp Quant Biol
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Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells.
Authors: Yang L, Grishin D, Wang G, Aach J, Zhang CZ, Chari R, Homsy J, Cai X, Zhao Y, Fan JB, Seidman C, Seidman J, Pu W, Church G.
Nat Commun
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EGFR variant heterogeneity in glioblastoma resolved through single-nucleus sequencing.
Authors: Francis JM, Zhang CZ, Maire CL, Jung J, Manzo VE, Adalsteinsson VA, Homer H, Haidar S, Blumenstiel B, Pedamallu CS, Ligon AH, Love JC, Meyerson M, Ligon KL.
Cancer Discov
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Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer.
Authors: Lohr JG, Adalsteinsson VA, Cibulskis K, Choudhury AD, Rosenberg M, Cruz-Gordillo P, Francis JM, Zhang CZ, Shalek AK, Satija R, Trombetta JJ, Lu D, Tallapragada N, Tahirova N, Kim S, Blumenstiel B, Sougnez C, Lowe A, Wong B, Auclair D, Van Allen EM, Nakabayashi M, Lis RT, Lee GS, Li T, Chabot MS, Ly A, Taplin ME, Clancy TE, Loda M, Regev A, Meyerson M, Hahn WC, Kantoff PW, Golub TR, Getz G, Boehm JS, Love JC.
Nat Biotechnol
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Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements.
Authors: Zhang CZ, Leibowitz ML, Pellman D.
Genes Dev
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Pan-cancer patterns of somatic copy number alteration.
Authors: Zack TI, Schumacher SE, Carter SL, Cherniack AD, Saksena G, Tabak B, Lawrence MS, Zhsng CZ, Wala J, Mermel CH, Sougnez C, Gabriel SB, Hernandez B, Shen H, Laird PW, Getz G, Meyerson M, Beroukhim R.
Nat Genet
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A mechanically stabilized receptor-ligand flex-bond important in the vasculature.
Authors: Kim J, Zhang CZ, Zhang X, Springer TA.
Nature
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Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor.
Authors: Zhang Q, Zhou YF, Zhang CZ, Zhang X, Lu C, Springer TA.
Proc Natl Acad Sci U S A
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