Denis Agniel

Denis Agniel, PhD

Lecturer on Biomedical Informatics, Part-time

Denis Agniel received his PhD from the Harvard School of Public Health under the supervision of Tianxi Cai.  Agniel’s research was focused on statistical methods for complex phenotypes where diverse measurements are required to accurately capture the multidimensionality of disorders. In this work, he used semi- and non-parametric methods to, for example, answer questions relating to genetic risk for multiple autoimmune diseases or detect genetic variants affecting HIV disease progression. His current research is primarily focused in three areas: (1) Using statistical methods for producing accurate data-driven phenotypes for heterogeneous neuropsychiatric disorders when true disease phenotypes are unknown. Of particular interest is incorporating longitudinal and time-to-event information into phenotype classification. (2) Understanding the impact of interdisciplinarity on translational science and, in particular, using large bibliometric databases to answer questions such as, "Do interdisciplinary teams produce more translational research?" (3) Ranging across a number of statistical areas such as resampling techniques and using non-parametric functional techniques to succinctly summarize longitudinal data for the purposes of testing and treatment selection.

Distinguishing neighborhood and individual social risk factors in health care.
Authors: Beckett MK, Martino SC, Agniel D, Mathews M, Hudson Scholle S, James C, Wilson-Frederick S, Orr N, Darabidian B, Elliott MN.
Health Serv Res
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Rates of Disenrollment From Medicare Advantage Plans Are Higher for Racial/Ethnic Minority Beneficiaries.
Authors: Martino SC, Mathews M, Damberg CL, Mallett JS, Orr N, Ng JH, Agniel D, Tamayo L, Elliott MN.
Med Care
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Evaluation of longitudinal surrogate markers.
Authors: Agniel D, Parast L.
Biometrics
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Pilot Randomized Controlled Trial of an Intervention to Improve Coping with Intersectional Stigma and Medication Adherence Among HIV-Positive Latinx Sexual Minority Men.
Authors: Bogart LM, Barreras JL, Gonzalez A, Klein DJ, Marsh T, Agniel D, Pantalone DW.
AIDS Behav
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Assessment of Variation in Electronic Health Record Capabilities and Reported Clinical Quality Performance in Ambulatory Care Clinics, 2014-2017.
Authors: Shekelle PG, Pane JD, Agniel D, Shi Y, Rumball-Smith J, Haas A, Fischer S, Rudin RS, Totten M, Lai J, Scanlon D, Damberg CL.
JAMA Netw Open
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Trends in Low-Value Health Service Use and Spending in the US Medicare Fee-for-Service Program, 2014-2018.
Authors: Mafi JN, Reid RO, Baseman LH, Hickey S, Totten M, Agniel D, Fendrick AM, Sarkisian C, Damberg CL.
JAMA Netw Open
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Identifying as American Indian/Alaska Native in Urban Areas: Implications for Adolescent Behavioral Health and Well-Being.
Authors: Brown RA, Dickerson DL, Klein DJ, Agniel D, Johnson CL, D'Amico EJ.
Youth Soc
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dearseq: a variance component score test for RNA-seq differential analysis that effectively controls the false discovery rate.
Authors: Gauthier M, Agniel D, Thiébaut R, Hejblum BP.
NAR Genom Bioinform
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Care integration within and outside health system boundaries.
Authors: Singer SJ, Sinaiko AD, Tietschert MV, Kerrissey M, Phillips RS, Martin V, Joseph G, Bahadurzada H, Agniel D.
Health Serv Res
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Distinguishing High-Performing Health Systems Using a Composite of Publicly Reported Measures of Ambulatory Care.
Authors: Agniel D, Haviland A, Shekelle P, Scherling A, Damberg CL.
Ann Intern Med
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