Griffin Weber
Griffin M Weber, M.D., Ph.D.
Associate Professor of Medicine, Beth Israel Deaconess Medical Center
Associate Professor of Biomedical Informatics, Harvard Medical School (Secondary)

Griffin Weber directs the Biomedical Research Informatics Core (BRIC) at BIDMC. A result of his research in expertise mining and social network analysis is his invention of an open source social networking website for scientists called Profiles RNS, now used at dozens of universities across the country. It automatically mines large datasets such as PubMed, NIH ExPORTER, and the U.S. patent database to discover investigators' research areas and scientific networks. It then presents these connections using temporal, geospatial, and network visualizations. The software has numerous applications, ranging from finding individual collaborators and mentors to understanding the dynamics of an entire research community.

Weber is also an investigator on Informatics for Integrating Biology and the Bedside (i2b2), an NIH National Center for Biomedical Computing, for which he helped developed a web-based open source platform that enables a variety of functions, including queries of large clinical repositories for hypothesis testing and identification of patients for clinical trials. He also created the original prototype software for the Shared Health Research Information Network (SHRINE), which is a federated query tool that connects i2b2 databases across multiple institutions. More than 100 institutions worldwide use i2b2 and SHRINE to support clinical research.

Weber received his M.D. and Ph.D. in computer science from Harvard University in 2007. While still a student, he became the first Chief Technology Officer of Harvard Medical School and built an educational web portal that provides interactive online content to over 500 courses. His past research projects also include analyzing DNA microarrays, modeling the growth of breast cancer tumors, and creating algorithms for predicting life expectancy.

Intracranial hemorrhage in patients with brain metastases treated with therapeutic enoxaparin: a matched cohort study.
Authors: Donato J, Campigotto F, Uhlmann EJ, Coletti E, Neuberg D, Weber GM, Zwicker JI.
Blood
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Federated queries of clinical data repositories: Scaling to a national network.
Authors: Weber GM.
J Biomed Inform
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Query Health: standards-based, cross-platform population health surveillance.
Authors: Klann JG, Buck MD, Brown J, Hadley M, Elmore R, Weber GM, Murphy SN.
J Am Med Inform Assoc
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Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): architecture.
Authors: Mandl KD, Kohane IS, McFadden D, Weber GM, Natter M, Mandel J, Schneeweiss S, Weiler S, Klann JG, Bickel J, Adams WG, Ge Y, Zhou X, Perkins J, Marsolo K, Bernstam E, Showalter J, Quarshie A, Ofili E, Hripcsak G, Murphy SN.
J Am Med Inform Assoc
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Finding the missing link for big biomedical data.
Authors: Weber GM, Mandl KD, Kohane IS.
JAMA
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The use and significance of a research networking system.
Authors: Kahlon M, Yuan L, Daigre J, Meeks E, Nelson K, Piontkowski C, Reuter K, Sak R, Turner B, Weber GM, Chatterjee A.
J Med Internet Res
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Federated queries of clinical data repositories: the sum of the parts does not equal the whole.
Authors: Weber GM.
J Am Med Inform Assoc
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Identifying translational science within the triangle of biomedicine.
Authors: Weber GM.
J Transl Med
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SHRINE: enabling nationally scalable multi-site disease studies.
Authors: McMurry AJ, Murphy SN, MacFadden D, Weber G, Simons WW, Orechia J, Bickel J, Wattanasin N, Gilbert C, Trevvett P, Churchill S, Kohane IS.
PLoS One
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An i2b2-based, generalizable, open source, self-scaling chronic disease registry.
Authors: Natter MD, Quan J, Ortiz DM, Bousvaros A, Ilowite NT, Inman CJ, Marsolo K, McMurry AJ, Sandborg CI, Schanberg LE, Wallace CA, Warren RW, Weber GM, Mandl KD.
J Am Med Inform Assoc
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