Peter Kharchenko

Peter Kharchenko, PhD

Research Collaborator
Former Associate Professor of Biomedical Informatics

Peter Kharchenko received a PhD in biophysics at Harvard University, studying gene regulation and metabolic networks under the advisement of George Church. He then completed a four-year postdoctoral fellowship in computational biology and genomics in the laboratory of DBMI's Peter Park. As a former Gilbert S. Omenn Associate Professor of Biomedical Informatics, he studied the epigenetic mechanisms that regulate the growth and maintenance of normal tissues as well as the disruptions of the epigenetic state that contribute to a variety of disorders.

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors.
Authors: Bedoya-Reina OC, Li W, Arceo M, Plescher M, Bullova P, Pui H, Kaucka M, Kharchenko P, Martinsson T, Holmberg J, Adameyko I, Deng Q, Larsson C, Juhlin CC, Kogner P, Schlisio S.
Nat Commun
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Population sequencing data reveal a compendium of mutational processes in the human germ line.
Authors: Seplyarskiy VB, Soldatov RA, Koch E, McGinty RJ, Goldmann JM, Hernandez RD, Barnes K, Correa A, Burchard EG, Ellinor PT, McGarvey ST, Mitchell BD, Vasan RS, Redline S, Silverman E, Weiss ST, Arnett DK, Blangero J, Boerwinkle E, He J, Montgomery C, Rao DC, Rotter JI, Taylor KD, Brody JA, Chen YI, de Las Fuentes L, Hwu CM, Rich SS, Manichaikul AW, Mychaleckyj JC, Palmer ND, Smith JA, Kardia SLR, Peyser PA, Bielak LF, O'Connor TD, Emery LS, Gilissen C, Wong WSW, Kharchenko PV, Sunyaev S.
Science
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RNA velocity-current challenges and future perspectives.
Authors: Bergen V, Soldatov RA, Kharchenko PV, Theis FJ.
Mol Syst Biol
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Publisher Correction: The triumphs and limitations of computational methods for scRNA-seq.
Authors: Kharchenko PV.
Nat Methods
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The triumphs and limitations of computational methods for scRNA-seq.
Authors: Kharchenko PV.
Nat Methods
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Evolutionary switch in expression of key markers between mouse and human leads to mis-assignment of cell types in developing adrenal medulla.
Authors: Kameneva P, V Artemov A, Kastriti ME, Sundström E, Kharchenko PV, Adameyko I.
Cancer Cell
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Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin.
Authors: Kameneva P, Artemov AV, Kastriti ME, Faure L, Olsen TK, Otte J, Erickson A, Semsch B, Andersson ER, Ratz M, Frisén J, Tischler AS, de Krijger RR, Bouderlique T, Akkuratova N, Vorontsova M, Gusev O, Fried K, Sundström E, Mei S, Kogner P, Baryawno N, Kharchenko PV, Adameyko I.
Nat Genet
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Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain.
Authors: Kupari J, Usoskin D, Parisien M, Lou D, Hu Y, Fatt M, Lönnerberg P, Spångberg M, Eriksson B, Barkas N, Kharchenko PV, Loré K, Khoury S, Diatchenko L, Ernfors P.
Nat Commun
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Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2.
Authors: Specht H, Emmott E, Petelski AA, Huffman RG, Perlman DH, Serra M, Kharchenko P, Koller A, Slavov N.
Genome Biol
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Author Correction: Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis.
Authors: Pfisterer U, Petukhov V, Demharter S, Meichsner J, Thompson JJ, Batiuk MY, Asenjo-Martinez A, Vasistha NA, Thakur A, Mikkelsen J, Adorjan I, Pinborg LH, Pers TH, von Engelhardt J, Kharchenko PV, Khodosevich K.
Nat Commun
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