Jake (June-Koo) Lee is a physician-scientist pursuing novel anticancer therapeutics based on his research experience in clinical oncology and cancer genomics.
Lee received his medical degree summa cum laude in 2008 from Seoul National University College of Medicine, South Korea. He did his internal medicine residency in Seoul National University Hospital from 2009 to 2013. During this time, he did clinical oncology research focusing on molecular targeted therapy in lung cancer. His meta-analysis of clinical trials provided clinical guidance on appropriate indication of EGFR tyrosine kinase inhibitors (Lee et al. 2014 JAMA; PMID 24715074), and he also designed and led the first investigator-initiated, phase II clinical trial of vandetanib in patients with lung adenocarcinoma harboring RET rearrangement (Lee et al. 2017 Ann Oncol; PMID 27803005).
Following his residency, Lee began translational cancer research at the Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST). There he pursued his academic interest in the histologic transformation process during EGFR tyrosine kinase inhibitor treatments, and explored the early-branched evolutionary history of small-cell transformed tumors (Lee et al. 2017 J Clin Oncol; in press). He also received his PhD in 2017.
Lee joined the Park lab in 2017 as a research fellow, and he is using large-scale whole-genome sequencing datasets to study the process by which genomic instability generates cancer driver mutations.
Nature, August 1, 2018
Nucleic acids research, July 2, 2018
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, May 12, 2017
Annals of oncology : official journal of the European Society for Medical Oncology, April 1, 2017
Annals of oncology : official journal of the European Society for Medical Oncology, February 1, 2017
The Lancet. Respiratory medicine, February 1, 2017
Annual review of pathology, February 22, 2016
The EMBO journal, December 14, 2015
Nature communications, April 7, 2015
Cancer cell, August 21, 2014