Sian Owen

Sian Victoria Owen, Ph.D.

Research Fellow in Biomedical Informatics

Sian_Owen@hms.harvard.edu

Tabs

Research

Mentor: Michael Baym, PhD

Siân Owen completed her PhD and a short postdoctoral fellowship at the University of Liverpool, UK, in the group of Professor Jay Hinton. Owen's research explored the biological contribution of temperate bacteriophages to an emerging variant of Salmonella enterica serovar Typhimurium that is associated with an epidemic of bloodstream infections in sub-Saharan Africa. She is currently working in the Baym Lab in the Department of Biomedical Informatics and the Laboratory of Systems Pharmacology using experimental evolution and computational approaches to study the phenomenon of antibiotic resistance in bacteria.

Publications

Role of a single noncoding nucleotide in the evolution of an epidemic African clade of Salmonella.

Sian Victoria Owen, Ph.D.

Proceedings of the National Academy of Sciences of the United States of America, February 27, 2018

Hammarlöf DL, Kröger C, Owen SV, Canals R, Lacharme-Lora L, Wenner N, Schager AE, Wells TJ, Henderson IR, Wigley P, Hokamp K, Feasey NA, Gordon MA, Hinton JCD

Link to abstract on PubMed

Public health surveillance in the UK revolutionises our understanding of the invasive Salmonella Typhimurium epidemic in Africa.

Sian Victoria Owen, Ph.D.

Genome medicine, October 31, 2017

Ashton PM, Owen SV, Kaindama L, Rowe WPM, Lane CR, Larkin L, Nair S, Jenkins C, de Pinna EM, Feasey NA, Hinton JCD, Dallman TJ

Link to abstract on PubMed

Direct characterization of the native structure and mechanics of cyanobacterial carboxysomes.

Sian Victoria Owen, Ph.D.

Nanoscale, August 3, 2017

Faulkner M, Rodriguez-Ramos J, Dykes GF, Owen SV, Casella S, Simpson DM, Beynon RJ, Liu LN

Link to abstract on PubMed

Characterization of the Prophage Repertoire of African Salmonella Typhimurium ST313 Reveals High Levels of Spontaneous Induction of Novel Phage BTP1.

Sian Victoria Owen, Ph.D.

Frontiers in microbiology, February 23, 2017

Owen SV, Wenner N, Canals R, Makumi A, Hammarlöf DL, Gordon MA, Aertsen A, Feasey NA, Hinton JC

Link to abstract on PubMed

What's in a Name? Species-Wide Whole-Genome Sequencing Resolves Invasive and Noninvasive Lineages of Salmonella enterica Serotype Paratyphi B.

Sian Victoria Owen, Ph.D.

mBio, August 23, 2016

Connor TR, Owen SV, Langridge G, Connell S, Nair S, Reuter S, Dallman TJ, Corander J, Tabing KC, Le Hello S, Fookes M, Doublet B, Zhou Z, Feltwell T, Ellington MJ, Herrera S, Gilmour M, Cloeckaert A, Achtman M, Parkhill J, Wain J, De Pinna E, Weill FX,...

Link to abstract on PubMed

RNA-seq Brings New Insights to the Intra-Macrophage Transcriptome of Salmonella Typhimurium.

Sian Victoria Owen, Ph.D.

PLoS pathogens, November 12, 2015

Srikumar S, Kröger C, Hébrard M, Colgan A, Owen SV, Sivasankaran SK, Cameron AD, Hokamp K, Hinton JC

Link to abstract on PubMed

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Tabs

Mentor: Michael Baym, PhD

Role of a single noncoding nucleotide in the evolution of an epidemic African clade of Salmonella.

Public health surveillance in the UK revolutionises our understanding of the invasive Salmonella Typhimurium epidemic in Africa.

Direct characterization of the native structure and mechanics of cyanobacterial carboxysomes.

Characterization of the Prophage Repertoire of African Salmonella Typhimurium ST313 Reveals High Levels of Spontaneous Induction of Novel Phage BTP1.

What's in a Name? Species-Wide Whole-Genome Sequencing Resolves Invasive and Noninvasive Lineages of Salmonella enterica Serotype Paratyphi B.

RNA-seq Brings New Insights to the Intra-Macrophage Transcriptome of Salmonella Typhimurium.