Peter Park
Peter J. Park, PhD
Professor of Biomedical Informatics
10 Shattuck Street, Boston, MA 02115

Peter Park is director of the HMS Bioinformatics and Integrative Genomics (BIG) PhD program. His Computational Genomics group specializes in computational and statistical analysis of high-throughput sequencing data to understand genetic and epigenetic mechanisms related to disease processes, especially in cancer. Originally trained in applied mathematics, Park earned a PhD, from Caltech and was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for chromatin and genome analysis and has made major contributions to large NIH consortium projects such as the model organism ENCyclopedia of DNA Elements (modENCODE) and The Cancer Genome Atlas. He has also collaborated with dozens of experimentalists over the years to study a wide range of genetic and epigenetic phenomena and their alterations, both in humans and in model organisms. He is a member of the Division of Genetics at Brigham and Women's Hospital, co-leader of the Biostatistics and Computational Biology Program at the Dana-Farber/Harvard Cancer Center, and director of the Center for Stem Cell Bioinformatics at the Harvard Stem Cell Institute.


DBMI Research Programs
DBMI Courses
Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells: Current Strategies and Limitations.
Authors: Jiang Y, Park P, Hong SM, Ban K.
Mol Cells
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EED, a member of the polycomb group, is required for nephron differentiation and the maintenance of nephron progenitor cells.
Authors: Zhang L, Ettou S, Khalid M, Taglienti M, Jain D, Jung YL, Seager C, Liu Y, Ng KH, Park PJ, Kreidberg JA.
Development
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A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases.
Authors: Zhang Y, Yang L, Kucherlapati M, Chen F, Hadjipanayis A, Pantazi A, Bristow CA, Lee EA, Mahadeshwar HS, Tang J, Zhang J, Seth S, Lee S, Ren X, Song X, Sun H, Seidman J, Luquette LJ, Xi R, Chin L, Protopopov A, Li W, Park PJ, Kucherlapati R, Creighton CJ.
Cell Rep
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The BabySeq project: implementing genomic sequencing in newborns.
Authors: Holm IA, Agrawal PB, Ceyhan-Birsoy O, Christensen KD, Fayer S, Frankel LA, Genetti CA, Krier JB, LaMay RC, Levy HL, McGuire AL, Parad RB, Park PJ, Pereira S, Rehm HL, Schwartz TS, Waisbren SE, Yu TW, Green RC, Beggs AH.
BMC Pediatr
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Detecting Somatic Mutations in Normal Cells.
Authors: Dou Y, Gold HD, Luquette LJ, Park PJ.
Trends Genet
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Comprehensive Characterization of Cancer Driver Genes and Mutations.
Authors: Bailey MH, Tokheim C, Porta-Pardo E, Sengupta S, Bertrand D, Weerasinghe A, Colaprico A, Wendl MC, Kim J, Reardon B, Ng PK, Jeong KJ, Cao S, Wang Z, Gao J, Gao Q, Wang F, Liu EM, Mularoni L, Rubio-Perez C, Nagarajan N, Cortés-Ciriano I, Zhou DC, Liang WW, Hess JM, Yellapantula VD, Tamborero D, Gonzalez-Perez A, Suphavilai C, Ko JY, Khurana E, Park PJ, Van Allen EM, Liang H, Lawrence MS, Godzik A, Lopez-Bigas N, Stuart J, Wheeler D, Getz G, Chen K, Lazar AJ, Mills GB, Karchin R, Ding L.
Cell
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Understanding patient preferences for femoral central venous catheterization among patients with sickle cell disease.
Authors: Park PJ, Cole SS, Bercu ZL, Martin J, Newsome J.
J Vasc Access
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PaSD-qc: quality control for single cell whole-genome sequencing data using power spectral density estimation.
Authors: Sherman MA, Barton AR, Lodato MA, Vitzthum C, Coulter ME, Walsh CA, Park PJ.
Nucleic Acids Res
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Aging and neurodegeneration are associated with increased mutations in single human neurons.
Authors: Lodato MA, Rodin RE, Bohrson CL, Coulter ME, Barton AR, Kwon M, Sherman MA, Vitzthum CM, Luquette LJ, Yandava CN, Yang P, Chittenden TW, Hatem NE, Ryu SC, Woodworth MB, Park PJ, Walsh CA.
Science
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Corrigendum: The 4D nucleome project.
Authors: Dekker J, Belmont AS, Guttman M, Leshyk VO, Lis JT, Lomvardas S, Mirny LA, O'Shea CC, Park PJ, Ren B, Politz JCR, Shendure J, Zhong S.
Nature
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