Shamil Sunyaev

Shamil Sunyaev, PhD

Professor of Biomedical Informatics, Harvard Medical School
Professor of Medicine, Brigham and Women’s Hospital

10 Shattuck Street, Room 311A, Boston, MA 02115

Sunyaev Lab

Shamil Sunyaev is a computational genomicist and geneticist. Research in his lab encompasses many aspects of population genetic variation including the origin of mutations, the effect of allelic variants on molecular function, population and evolutionary genetics, and genetics of human complex and Mendelian traits. He developed several computational and statistical methods widely adopted by the community. Sunyaev obtained a PhD in molecular biophysics from the Moscow Institute of Physics and Technology and completed his postdoctoral training in bioinformatics at the European Molecular Biology Laboratory (EMBL). He is an Institute Member at Broad Institute of MIT and Harvard. He also co-organizes the Boston Evolutionary Genomics Supergroup.


DBMI Research Areas
DBMI Courses
NERINE reveals rare variant associations in gene networks across phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson's disease.
Authors: Nazeen S, Wang X, Morrow AR, Strom R, Ethier E, Ritter D, Henderson ABH, Afroz J, Cassa CS, Stitziel NO, Gupta RM, Luk KC, Studer L, Khurana V, Sunyaev SR.
Cell Genom
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Inference of elevated mutation rates and variant effects using 700k exomes.
Authors: Kar P, Moldovan MA, Guez J, Nazeen S, Goodrich JK, Karani T, Samocha KE, Karczewski KJ, Koch E, Seplyarskiy V, Sunyaev SR.
bioRxiv
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Incorporation of clinical and molecular variant properties improves the performance of in silico pathogenicity prediction tools.
Authors: Isakov O, Ashwal-Fluss R, Marek-Yagel D, Sunyaev S, Ben-Shachar S.
Genet Med
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Systematic analysis of snRNA genes reveals frequent RNU2-2 variants in dominant and recessive developmental and epileptic encephalopathies.
Authors: Leitão E, Santini A, Cogne B, Essid M, Athanasiadou M, LaFlamme CW, Marijon P, Bernard V, Jousselin K, Chatron N, Barcia G, Keren B, Mignot C, Charles P, Besnard T, Paluch R, de Sainte Agathe JM, Almanza Fuerte EP, Sengupta S, Milh M, Ramond F, Allan T, An I, Araujo C, Arpin S, Austin-Tse C, Auvin S, Baer S, Bahi-Buisson N, Bak M, Barth M, Baulac S, Bednarek-Weirauch N, Begemann M, Bennett MF, Bensabath U, Bézieau S, Bhouri R, Biehler M, Hammer TB, Bogoin J, Bonanno E, Boussion S, Bris C, Brosseau-Beauvir A, Bruel AL, Briand-Suleau A, Buratti J, Celse T, Chambon P, Chemaly N, Chesneau B, Colin E, Colmard M, Colson C, Conrad S, Courtin T, Creveaux I, Cullier AC, Dang LT, de Saint Martin A, de Vanssay de Blavous Legendre C, Demeer B, Denommé-Pichon AS, Diekhoff P, DiTroia S, Doco-Fenzy M, Dubourg C, Dubucs C, Ducreux S, Dufour L, Duquet R, Durand B, El Chehadeh S, Elbracht M, Faivre L, Faoucher M, Faudet A, Forlani S, Fradin M, Gaignard P, Ganne B, Garde A, Géraud J, Gill D, Goldenberg A, Grabli D, Grisel C, Gueden S, Gueguen P, Guerrot AM, Guichet A, Haack TB, Härting N, Häusler MG, Heide S, Herget T, Héron B, Héron D, Herwig J, Heulin M, Holling T, Houdayer C, Isidor B, Jacquette A, Januel L, Jean-Marçais N, Kaiser FJ, Kaya S, King C, Konyukh M, Kraft F, Krause J, Kirstetter R, Kuechler A, Kurth I, Kutsche K, Labalme A, Laloy JS, Laugel V, Le Bricquir F, Lèbre AS, Lebrun M, Leguern E, Levy J, Lieffering N, Lyonnet S, Lüthy K, Macdonald SMW, Mansour-Hendili L, Maraval J, Marquardt I, Mattausch C, Mercier S, Messaoud O, Morel G, Mortreux J, Munnich A, Nabbout R, Nambot S, Navarro V, Neale A, Nguyen L, Nizon M, Nowak F, O'Leary MC, Odent S, Ojeda NM, Olin V, Olivieri S, Õunap K, Pais LS, Panagiotakaki E, Patat O, Perrin-Sabourin L, Petit F, Philippe C, Piton A, Planes M, Poirsier C, Pouzet A, Prouteau C, Quéméner-Redon S, Renaud M, Richard AC, Rio M, Rivier C, Robin-Renaldo F, Rollier P, Rossi M, Roubertie A, Ruault V, Rupin-Mas M, Saugier-Veber P, Saunier A, Saneto R, Sarrazin E, Sarret C, Schaefer E, Schluth-Bolard C, Schneider A, Schumann I, Seplyarskiy VB, Spranger S, Smol T, Sturm M, Sunyaev SR, Sperelakis-Beedham B, Stenton SL, Stock F, Tharreau M, Torun D, Toulouse J, Thiyagarajah H, Valence S, Valleix S, Van-Gils J, Villard L, Ville D, Villeneuve N, Vitobello A, Waernessyckle A, Wagner J, Weber Y, Wieczorek D, Witkowski T, Yadavilli M, Yammine T, Zaafrane-Khachnaoui K, Zaki MS, Ziegler A, Bramswig NC, Lermine A, Nicolas G, Gleeson JG, Sadleir LG, Hildebrand MS, Scheffer IE, Whiffin N, O'Donnell-Luria A, Mefford HC, Blanc P, Thevenon J, Charbonnier C, Charenton C, Depienne C, Lesca G, Nava C.
Nat Genet
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Integrating 730,947 exome sequences with clinical literature improves gene discovery.
Authors: Guez J, Goodrich JK, Moldovan MA, Chao KR, Kar P, Panchal R, Wilson MW, Laricchia KM, Rohlicek G, Biba D, Marten D, He Q, Darnowsky PW, Grant R, Weisburd B, Baxter SM, Nadeau J, Lu W, Jahl S, Parsa S, Lamane A, DiTroia S, Fu J, Zhao X, Alarmani E, Tolonen C, Novod S, Bryant S, Stevens C, Chapman SB, Cusick C, Vittal C, Gauthier LD, Goldstein JI, Goldstein D, King D, Poterba T, Tiao G, Tranchero M, Lotter W, MacArthur DG, Brand H, Seplyarskiy V, Koch E, Talkowski ME, Solomonson M, Neale BM, O'Donnell-Luria A, Finucane HK, Sunyaev SR, Daly MJ, Rehm HL, Samocha KE, Karczewski KJ.
medRxiv
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Farm animal evolution demonstrates hidden molecular basis of human traits.
Authors: Connally NJ, Sunyaev S.
bioRxiv
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FAVOR 2.0: A reengineered functional annotation of variants online resource for interpreting genomic variation.
Authors: Zhou H, Verma V, Li X, Li Z, Shedd N, Li TC, Yang H, Zhang A, Borsari B, Buyske S, Gerstein M, Matise T, Zody MC, Neale B, Weng Z, Sunyaev SR, Lin X.
Nucleic Acids Res
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Learning Patient Similarity from Genomics for Precision Oncology.
Authors: Shady M, Reardon B, Jiang S, Pimenta E, O'Meara T, Park J, Kehl KL, Elmarakeby HA, Sunyaev SR, Van Allen EM.
medRxiv
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Inherent instability of simple DNA repeats shapes an evolutionarily stable distribution of repeat lengths.
Authors: McGinty RJ, Balick DJ, Mirkin SM, Sunyaev SR.
Nat Commun
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Hotspots of human mutation point to clonal expansions in spermatogonia.
Authors: Seplyarskiy V, Moldovan MA, Koch E, Kar P, Neville MDC, Rahbari R, Sunyaev S.
Nature
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