Shamil Sunyaev
Shamil Sunyaev, PhD
Professor of Biomedical Informatics, Harvard Medical School
Professor of Medicine, Brigham and Women’s Hospital
10 Shattuck Street, Room 311A, Boston, MA 02115

Shamil Sunyaev is a computational genomicist and geneticist. Research in his lab encompasses many aspects of population genetic variation including the origin of mutations, the effect of allelic variants on molecular function, population and evolutionary genetics, and genetics of human complex and Mendelian traits. He developed several computational and statistical methods widely adopted by the community. Sunyaev obtained a PhD in molecular biophysics from the Moscow Institute of Physics and Technology and completed his postdoctoral training in bioinformatics at the European Molecular Biology Laboratory (EMBL). He is an Associate Member at Broad Institute of MIT and Harvard. He co-leads the NHGRI-funded Genome Sequencing Program Analysis Center and is actively involved in the Undiagnosed Diseases Network and in the Brigham Genomic Medicine program. He also co-organizes the Boston Evolutionary Genomics Group.


DBMI Research Areas
DBMI Courses
Author Correction: The origin of human mutation in light of genomic data.
Authors: Seplyarskiy VB, Sunyaev S.
Nat Rev Genet
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The origin of human mutation in light of genomic data.
Authors: Seplyarskiy VB, Sunyaev S.
Nat Rev Genet
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Population sequencing data reveal a compendium of mutational processes in the human germ line.
Authors: Seplyarskiy VB, Soldatov RA, Koch E, McGinty RJ, Goldmann JM, Hernandez RD, Barnes K, Correa A, Burchard EG, Ellinor PT, McGarvey ST, Mitchell BD, Vasan RS, Redline S, Silverman E, Weiss ST, Arnett DK, Blangero J, Boerwinkle E, He J, Montgomery C, Rao DC, Rotter JI, Taylor KD, Brody JA, Chen YI, de Las Fuentes L, Hwu CM, Rich SS, Manichaikul AW, Mychaleckyj JC, Palmer ND, Smith JA, Kardia SLR, Peyser PA, Bielak LF, O'Connor TD, Emery LS, Gilissen C, Wong WSW, Kharchenko PV, Sunyaev S.
Science
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Replicate sequencing libraries are important for quantification of allelic imbalance.
Authors: Mendelevich A, Vinogradova S, Gupta S, Mironov AA, Sunyaev SR, Gimelbrant AA.
Nat Commun
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Purifying selection on noncoding deletions of human regulatory loci detected using their cellular pleiotropy.
Authors: Radke DW, Sul JH, Balick DJ, Akle S, Green RC, Sunyaev SR.
Genome Res
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Commonalities across computational workflows for uncovering explanatory variants in undiagnosed cases.
Authors: Kobren SN, Baldridge D, Velinder M, Krier JB, LeBlanc K, Esteves C, Pusey BN, Züchner S, Blue E, Lee H, Huang A, Bastarache L, Bican A, Cogan J, Marwaha S, Alkelai A, Murdock DR, Liu P, Wegner DJ, Paul AJ, Sunyaev SR, Kohane IS.
Genet Med
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Maintenance of Adaptive Dynamics and No Detectable Load in a Range-Edge Outcrossing Plant Population.
Authors: Takou M, Hämälä T, Koch EM, Steige KA, Dittberner H, Yant L, Genete M, Sunyaev S, Castric V, Vekemans X, Savolainen O, Meaux J.
Mol Biol Evol
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Shared associations identify causal relationships between gene expression and immune cell phenotypes.
Authors: Gasperi C, Chun S, Sunyaev SR, Cotsapas C.
Commun Biol
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Population-specific causal disease effect sizes in functionally important regions impacted by selection.
Authors: Shi H, Gazal S, Kanai M, Koch EM, Schoech AP, Siewert KM, Kim SS, Luo Y, Amariuta T, Huang H, Okada Y, Raychaudhuri S, Sunyaev SR, Price AL.
Nat Commun
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Polygenic adaptation of rosette growth in Arabidopsis thaliana.
Authors: Wieters B, Steige KA, He F, Koch EM, Ramos-Onsins SE, Gu H, Guo YL, Sunyaev S, de Meaux J.
PLoS Genet
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