Zak Kohane
Isaac Kohane, MD, PhD
Chair of the Department of Biomedical Informatics, Harvard Medical School
Marion V. Nelson Professor of Biomedical Informatics, Harvard Medical School
10 Shattuck Street, Boston, MA 02115

Over the last 30 years, the research agenda of Isaac Kohane  has been driven by the vision of what biomedical researchers could do to find new cures, provide new diagnoses and deliver the best care available if data could be converted more rapidly to knowledge and knowledge to practice. In so doing, Kohane has designed and led multiple internationally adopted efforts to “instrument” the healthcare enterprise for discovery and to enable innovative decision-making tools to be applied to the point of care. At the same time, the new insights afforded by ’omic-scale molecular analyses have inspired him and his collaborators to work on re-characterizing and reclassifying diseases such as autism, rheumatoid arthritis and cancers. In many of these studies, the developmental trajectories of thousands of genes have been a powerful tool in unraveling complex diseases. Kohane currently leads three NIH-funded projects that cut across the entire agenda:

  1. A Center for Excellence in Genomic Science to study neuropsychiatric disease at multiple levels (from molecular characterization of induced neurons obtained from fibroblasts of patients to automated classification of the textual component of their electronic medical record).
  2. The Coordinating Center for the Undiagnosed Diseases Network. Where patients with rare and unknown diseases are provided with combined clinical and molecular diagnoses in a nationally-scaled infrastructure so that they can see the right expert with all their relevant data at hand.
  3. Center for Excellence in Big Data to Knowledge to both create a nationally scaleable research data-sharing infrastructure and demonstrate its use for neurodevelopmental diseases.

Kohane is always on the look out for like-minded “quants” who share the same goals to bring a better future for medicine and biomedical science to the present.

DBMI Research Areas
DBMI Courses
Current Postdoctoral Fellowship Opportunities
AI for the Eye - Automated Assistance for Clinicians Screening for Papilledema.
Authors: Kohane I.
N Engl J Med
View full abstract on Pubmed
An Interactive Online Dashboard for Tracking COVID-19 in U.S. Counties, Cities, and States in Real Time.
Authors: Wissel BD, Van Camp PJ, Kouril M, Weis C, Glauser TA, White PS, Kohane IS, Dexheimer JW.
J Am Med Inform Assoc
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Examining the Use of Real-World Evidence in the Regulatory Process.
Authors: Beaulieu-Jones BK, Finlayson SG, Yuan W, Altman RB, Kohane IS, Prasad V, Yu KH.
Clin Pharmacol Ther
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Data Citizenship under the 21st Century Cures Act.
Authors: Mandl KD, Kohane IS.
N Engl J Med
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Making the 'invisible' visible: transforming the detection of intimate partner violence.
Authors: Khurana B, Seltzer SE, Kohane IS, Boland GW.
BMJ Qual Saf
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The phenotypical implications of immune dysregulation in fragile X syndrome.
Authors: Yu KH, Palmer N, Fox K, Prock L, Mandl KD, Kohane IS, Prilutsky D.
Eur J Neurol
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Estimates of healthcare spending for preterm and low-birthweight infants in a commercially insured population: 2008-2016.
Authors: Beam AL, Fried I, Palmer N, Agniel D, Brat G, Fox K, Kohane I, Sinaiko A, Zupancic JAF, Armstrong J.
J Perinatol
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Autoimmune Effects of Lung Cancer Immunotherapy Revealed by Data-Driven Analysis on a Nationwide Cohort.
Authors: Yang S, Yu KH, Palmer N, Fox K, Kou SC, Kohane IS.
Clin Pharmacol Ther
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Big Data in the Assessment of Pediatric Medication Safety.
Authors: McMahon AW, Cooper WO, Brown JS, Carleton B, Doshi-Velez F, Kohane I, Goldman JL, Hoffman MA, Kamaleswaran R, Sakiyama M, Sekine S, Sturkenboom MCJM, Turner MA, Califf RM.
View full abstract on Pubmed
Clinical Concept Embeddings Learned from Massive Sources of Multimodal Medical Data.
Authors: Beam AL, Kompa B, Schmaltz A, Fried I, Weber G, Palmer N, Shi X, Cai T, Kohane IS.
Pac Symp Biocomput
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