Zak Kohane
Isaac Kohane, MD, PhD
Marion V. Nelson Professor of Biomedical Informatics, Harvard Medical School
Chair of the Department of Biomedical Informatics, Harvard Medical School
Associate Professor of Medicine, Brigham and Women's Hospital
10 Shattuck Street, Boston, MA 02115

Over the last 30 years, the research agenda of Isaac Kohane  has been driven by the vision of what biomedical researchers could do to find new cures, provide new diagnoses and deliver the best care available if data could be converted more rapidly to knowledge and knowledge to practice. In so doing, Kohane has designed and led multiple internationally adopted efforts to “instrument” the healthcare enterprise for discovery and to enable innovative decision-making tools to be applied to the point of care. At the same time, the new insights afforded by ’omic-scale molecular analyses have inspired him and his collaborators to work on re-characterizing and reclassifying diseases such as autism, rheumatoid arthritis and cancers. In many of these studies, the developmental trajectories of thousands of genes have been a powerful tool in unraveling complex diseases. Kohane currently leads three NIH-funded projects that cut across the entire agenda:

  1. A Center for Excellence in Genomic Science to study neuropsychiatric disease at multiple levels (from molecular characterization of induced neurons obtained from fibroblasts of patients to automated classification of the textual component of their electronic medical record).
  2. The Coordinating Center for the Undiagnosed Diseases Network. Where patients with rare and unknown diseases are provided with combined clinical and molecular diagnoses in a nationally-scaled infrastructure so that they can see the right expert with all their relevant data at hand.
  3. Center for Excellence in Big Data to Knowledge to both create a nationally scaleable research data-sharing infrastructure and demonstrate its use for neurodevelopmental diseases.

Kohane is always on the look out for like-minded “quants” who share the same goals to bring a better future for medicine and biomedical science to the present.

DBMI Research Areas
DBMI Courses
Current Postdoctoral Fellowship Opportunities
Deciphering serous ovarian carcinoma histopathology and platinum response by convolutional neural networks.
Authors: Yu KH, Hu V, Wang F, Matulonis UA, Mutter GL, Golden JA, Kohane IS.
View full abstract on Pubmed
A multidimensional precision medicine approach identifies an autism subtype characterized by dyslipidemia.
Authors: Luo Y, Eran A, Palmer N, Avillach P, Levy-Moonshine A, Szolovits P, Kohane IS.
Nat Med
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Reproducible Machine Learning Methods for Lung Cancer Detection Using Computed Tomography Images: Algorithm Development and Validation.
Authors: Yu KH, Lee TM, Yen MH, Kou SC, Rosen B, Chiang JH, Kohane IS.
J Med Internet Res
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EHRtemporalVariability: delineating temporal data-set shifts in electronic health records.
Authors: Sáez C, Gutiérrez-Sacristán A, Kohane I, García-Gómez JM, Avillach P.
View full abstract on Pubmed
Scalability and cost-effectiveness analysis of whole genome-wide association studies on Google Cloud Platform and Amazon Web Services.
Authors: Krissaane I, De Niz C, Gutiérrez-Sacristán A, Korodi G, Ede N, Kumar R, Lyons J, Manrai A, Patel C, Kohane I, Avillach P.
J Am Med Inform Assoc
View full abstract on Pubmed
Classifying non-small cell lung cancer types and transcriptomic subtypes using convolutional neural networks.
Authors: Yu KH, Wang F, Berry GJ, Ré C, Altman RB, Snyder M, Kohane IS.
J Am Med Inform Assoc
View full abstract on Pubmed
AI for the Eye - Automated Assistance for Clinicians Screening for Papilledema.
Authors: Kohane I.
N Engl J Med
View full abstract on Pubmed
An Interactive Online Dashboard for Tracking COVID-19 in U.S. Counties, Cities, and States in Real Time.
Authors: Wissel BD, Van Camp PJ, Kouril M, Weis C, Glauser TA, White PS, Kohane IS, Dexheimer JW.
J Am Med Inform Assoc
View full abstract on Pubmed
Examining the Use of Real-World Evidence in the Regulatory Process.
Authors: Beaulieu-Jones BK, Finlayson SG, Yuan W, Altman RB, Kohane IS, Prasad V, Yu KH.
Clin Pharmacol Ther
View full abstract on Pubmed
Data Citizenship under the 21st Century Cures Act.
Authors: Mandl KD, Kohane IS.
N Engl J Med
View full abstract on Pubmed