Peter Park
Peter Park, PhD
Professor of Biomedical Informatics, Harvard Medical School
10 Shattuck Street, Boston, MA 02115

Peter Park is director of the HMS Bioinformatics and Integrative Genomics (BIG) PhD program. His Computational Genomics group specializes in computational and statistical analysis of high-throughput sequencing data to understand genetic and epigenetic mechanisms related to disease processes, especially in cancer. Originally trained in applied mathematics, Park earned a PhD, from Caltech and was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for chromatin and genome analysis and has made major contributions to large NIH consortium projects such as the model organism ENCyclopedia of DNA Elements (modENCODE) and The Cancer Genome Atlas. He has also collaborated with dozens of experimentalists over the years to study a wide range of genetic and epigenetic phenomena and their alterations, both in humans and in model organisms. He is a member of the Division of Genetics at Brigham and Women's Hospital, co-leader of the Biostatistics and Computational Biology Program at the Dana-Farber/Harvard Cancer Center, and director of the Center for Stem Cell Bioinformatics at the Harvard Stem Cell Institute.


DBMI Research Areas
DBMI Courses
Genomics of MPNST (GeM) Consortium: Rationale and Study Design for Multi-Omic Characterization of NF1-Associated and Sporadic MPNSTs.
Authors: Miller DT, Cortés-Ciriano I, Pillay N, Hirbe AC, Snuderl M, Bui MM, Piculell K, Al-Ibraheemi A, Dickson BC, Hart J, Jones K, Jordan JT, Kim RH, Lindsay D, Nishida Y, Ullrich NJ, Wang X, Park PJ, Flanagan AM.
Genes (Basel)
View full abstract on Pubmed
Mechanisms and therapeutic implications of hypermutation in gliomas.
Authors: Touat M, Li YY, Boynton AN, Spurr LF, Iorgulescu JB, Bohrson CL, Cortes-Ciriano I, Birzu C, Geduldig JE, Pelton K, Lim-Fat MJ, Pal S, Ferrer-Luna R, Ramkissoon SH, Dubois F, Bellamy C, Currimjee N, Bonardi J, Qian K, Ho P, Malinowski S, Taquet L, Jones RE, Shetty A, Chow KH, Sharaf R, Pavlick D, Albacker LA, Younan N, Baldini C, Verreault M, Giry M, Guillerm E, Ammari S, Beuvon F, Mokhtari K, Alentorn A, Dehais C, Houillier C, Laigle-Donadey F, Psimaras D, Lee EQ, Nayak L, McFaline-Figueroa JR, Carpentier A, Cornu P, Capelle L, Mathon B, Barnholtz-Sloan JS, Chakravarti A, Bi WL, Chiocca EA, Fehnel KP, Alexandrescu S, Chi SN, Haas-Kogan D, Batchelor TT, Frampton GM, Alexander BM, Huang RY, Ligon AH, Coulet F, Delattre JY, Hoang-Xuan K, Meredith DM, Santagata S, Duval A, Sanson M, Cherniack AD, Wen PY, Reardon DA, Marabelle A, Park PJ, Idbaih A, Beroukhim R, Bandopadhayay P, Bielle F, Ligon KL.
Nature
View full abstract on Pubmed
HiNT: a computational method for detecting copy number variations and translocations from Hi-C data.
Authors: Wang S, Lee S, Chu C, Jain D, Kerpedjiev P, Nelson GM, Walsh JM, Alver BH, Park PJ.
Genome Biol
View full abstract on Pubmed
Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer.
Authors: Färkkilä A, Gulhan DC, Casado J, Jacobson CA, Nguyen H, Kochupurakkal B, Maliga Z, Yapp C, Chen YA, Schapiro D, Zhou Y, Graham JR, Dezube BJ, Munster P, Santagata S, Garcia E, Rodig S, Lako A, Chowdhury D, Shapiro GI, Matulonis UA, Park PJ, Hautaniemi S, Sorger PK, Swisher EM, D'Andrea AD, Konstantinopoulos PA.
Nat Commun
View full abstract on Pubmed
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing.
Authors: Cortés-Ciriano I, Lee JJ, Xi R, Jain D, Jung YL, Yang L, Gordenin D, Klimczak LJ, Zhang CZ, Pellman DS, Park PJ.
Nat Genet
View full abstract on Pubmed
Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition.
Authors: Rodriguez-Martin B, Alvarez EG, Baez-Ortega A, Zamora J, Supek F, Demeulemeester J, Santamarina M, Ju YS, Temes J, Garcia-Souto D, Detering H, Li Y, Rodriguez-Castro J, Dueso-Barroso A, Bruzos AL, Dentro SC, Blanco MG, Contino G, Ardeljan D, Tojo M, Roberts ND, Zumalave S, Edwards PAW, Weischenfeldt J, Puiggròs M, Chong Z, Chen K, Lee EA, Wala JA, Raine K, Butler A, Waszak SM, Navarro FCP, Schumacher SE, Monlong J, Maura F, Bolli N, Bourque G, Gerstein M, Park PJ, Wedge DC, Beroukhim R, Torrents D, Korbel JO, Martincorena I, Fitzgerald RC, Van Loo P, Kazazian HH, Burns KH, Campbell PJ, Tubio JMC.
Nat Genet
View full abstract on Pubmed
Accurate detection of mosaic variants in sequencing data without matched controls.
Authors: Dou Y, Kwon M, Rodin RE, Cortés-Ciriano I, Doan R, Luquette LJ, Galor A, Bohrson C, Walsh CA, Park PJ.
Nat Biotechnol
View full abstract on Pubmed
Genomic footprints of activated telomere maintenance mechanisms in cancer.
Authors: Sieverling L, Hong C, Koser SD, Ginsbach P, Kleinheinz K, Hutter B, Braun DM, Cortés-Ciriano I, Xi R, Kabbe R, Park PJ, Eils R, Schlesner M, Brors B, Rippe K, Jones DTW, Feuerbach L.
Nat Commun
View full abstract on Pubmed
Efficacy of Intraprocedural Superior Hypogastric Nerve Block in Reduction of Postuterine Artery Embolization Narcotic Analgesia Use.
Authors: Park PJ, Kokabi N, Nadendla P, Lindsey T, Dariushnia SR.
Can Assoc Radiol J
View full abstract on Pubmed
GiniQC: a measure for quantifying noise in single-cell Hi-C data.
Authors: Horton CA, Alver BH, Park PJ.
Bioinformatics
View full abstract on Pubmed