Peter Park
Peter Park, Ph.D.
Professor of Biomedical Informatics, Harvard Medical School
10 Shattuck Street, Boston, MA 02115

Peter Park is director of the HMS Bioinformatics and Integrative Genomics (BIG) PhD program. His Computational Genomics group specializes in computational and statistical analysis of high-throughput sequencing data to understand genetic and epigenetic mechanisms related to disease processes, especially in cancer. Originally trained in applied mathematics, Park earned a PhD, from Caltech and was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for chromatin and genome analysis and has made major contributions to large NIH consortium projects such as the model organism ENCyclopedia of DNA Elements (modENCODE) and The Cancer Genome Atlas. He has also collaborated with dozens of experimentalists over the years to study a wide range of genetic and epigenetic phenomena and their alterations, both in humans and in model organisms. He is a member of the Division of Genetics at Brigham and Women's Hospital, co-leader of the Biostatistics and Computational Biology Program at the Dana-Farber/Harvard Cancer Center, and director of the Center for Stem Cell Bioinformatics at the Harvard Stem Cell Institute.


DBMI Research Areas
DBMI Courses
Identification and Genotyping of Transposable Element Insertions From Genome Sequencing Data.
Authors: Chu C, Zhao B, Park PJ, Lee EA.
Curr Protoc Hum Genet
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A user guide for the online exploration and visualization of PCAWG data.
Authors: Goldman MJ, Zhang J, Fonseca NA, Cortés-Ciriano I, Xiang Q, Craft B, Piñeiro-Yáñez E, O'Connor BD, Bazant W, Barrera E, Muñoz-Pomer A, Petryszak R, Füllgrabe A, Al-Shahrour F, Keays M, Haussler D, Weinstein JN, Huber W, Valencia A, Park PJ, Papatheodorou I, Zhu J, Ferretti V, Vazquez M.
Nat Commun
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Dysregulation of cancer genes by recurrent intergenic fusions.
Authors: Yun JW, Yang L, Park HY, Lee CW, Cha H, Shin HT, Noh KW, Choi YL, Park WY, Park PJ.
Genome Biol
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Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injury.
Authors: Ettou S, Jung YL, Miyoshi T, Jain D, Hiratsuka K, Schumacher V, Taglienti ME, Morizane R, Park PJ, Kreidberg JA.
Sci Adv
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Parallel RNA and DNA analysis after deep sequencing (PRDD-seq) reveals cell type-specific lineage patterns in human brain.
Authors: Huang AY, Li P, Rodin RE, Kim SN, Dou Y, Kenny CJ, Akula SK, Hodge RD, Bakken TE, Miller JA, Lein ES, Park PJ, Lee EA, Walsh CA.
Proc Natl Acad Sci U S A
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Author Correction: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer.
Authors: Färkkilä A, Gulhan DC, Casado J, Jacobson CA, Nguyen H, Kochupurakkal B, Maliga Z, Yapp C, Chen YA, Schapiro D, Zhou Y, Graham JR, Dezube BJ, Munster P, Santagata S, Garcia E, Rodig S, Lako A, Chowdhury D, Shapiro GI, Matulonis UA, Park PJ, Hautaniemi S, Sorger PK, Swisher EM, D'Andrea AD, Konstantinopoulos PA.
Nat Commun
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Publisher Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing.
Authors: Cortés-Ciriano I, Lee JJ, Xi R, Jain D, Jung YL, Yang L, Gordenin D, Klimczak LJ, Zhang CZ, Pellman DS, Park PJ.
Nat Genet
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Genomics of MPNST (GeM) Consortium: Rationale and Study Design for Multi-Omic Characterization of NF1-Associated and Sporadic MPNSTs.
Authors: Miller DT, Cortés-Ciriano I, Pillay N, Hirbe AC, Snuderl M, Bui MM, Piculell K, Al-Ibraheemi A, Dickson BC, Hart J, Jones K, Jordan JT, Kim RH, Lindsay D, Nishida Y, Ullrich NJ, Wang X, Park PJ, Flanagan AM.
Genes (Basel)
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Mechanisms and therapeutic implications of hypermutation in gliomas.
Authors: Touat M, Li YY, Boynton AN, Spurr LF, Iorgulescu JB, Bohrson CL, Cortes-Ciriano I, Birzu C, Geduldig JE, Pelton K, Lim-Fat MJ, Pal S, Ferrer-Luna R, Ramkissoon SH, Dubois F, Bellamy C, Currimjee N, Bonardi J, Qian K, Ho P, Malinowski S, Taquet L, Jones RE, Shetty A, Chow KH, Sharaf R, Pavlick D, Albacker LA, Younan N, Baldini C, Verreault M, Giry M, Guillerm E, Ammari S, Beuvon F, Mokhtari K, Alentorn A, Dehais C, Houillier C, Laigle-Donadey F, Psimaras D, Lee EQ, Nayak L, McFaline-Figueroa JR, Carpentier A, Cornu P, Capelle L, Mathon B, Barnholtz-Sloan JS, Chakravarti A, Bi WL, Chiocca EA, Fehnel KP, Alexandrescu S, Chi SN, Haas-Kogan D, Batchelor TT, Frampton GM, Alexander BM, Huang RY, Ligon AH, Coulet F, Delattre JY, Hoang-Xuan K, Meredith DM, Santagata S, Duval A, Sanson M, Cherniack AD, Wen PY, Reardon DA, Marabelle A, Park PJ, Idbaih A, Beroukhim R, Bandopadhayay P, Bielle F, Ligon KL.
Nature
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HiNT: a computational method for detecting copy number variations and translocations from Hi-C data.
Authors: Wang S, Lee S, Chu C, Jain D, Kerpedjiev P, Nelson GM, Walsh JM, Alver BH, Park PJ.
Genome Biol
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