Peter Park
Peter Park, PhD
Professor of Biomedical Informatics, Harvard Medical School
10 Shattuck Street, Boston, MA 02115

Peter Park is director of the HMS Bioinformatics and Integrative Genomics (BIG) PhD program. His Computational Genomics group specializes in computational and statistical analysis of high-throughput sequencing data to understand genetic and epigenetic mechanisms related to disease processes, especially in cancer. Originally trained in applied mathematics, Park earned a PhD, from Caltech and was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for chromatin and genome analysis and has made major contributions to large NIH consortium projects such as the model organism ENCyclopedia of DNA Elements (modENCODE) and The Cancer Genome Atlas. He has also collaborated with dozens of experimentalists over the years to study a wide range of genetic and epigenetic phenomena and their alterations, both in humans and in model organisms. He is a member of the Division of Genetics at Brigham and Women's Hospital, co-leader of the Biostatistics and Computational Biology Program at the Dana-Farber/Harvard Cancer Center, and director of the Center for Stem Cell Bioinformatics at the Harvard Stem Cell Institute.


DBMI Research Areas
DBMI Courses
Somatic mutation accumulation seen through a single-molecule lens.
Authors: Luquette LJ, Park PJ.
Cell Res
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Comprehensive identification of transposable element insertions using multiple sequencing technologies.
Authors: Chu C, Borges-Monroy R, Viswanadham VV, Lee S, Li H, Lee EA, Park PJ.
Nat Commun
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Predicting future from past: The genomic basis of recurrent and rapid stickleback evolution.
Authors: Roberts Kingman GA, Vyas DN, Jones FC, Brady SD, Chen HI, Reid K, Milhaven M, Bertino TS, Aguirre WE, Heins DC, von Hippel FA, Park PJ, Kirch M, Absher DM, Myers RM, Di Palma F, Bell MA, Kingsley DM, Veeramah KR.
Sci Adv
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HiTea: a computational pipeline to identify non-reference transposable element insertions in Hi-C data.
Authors: Jain D, Chu C, Alver BH, Lee S, Lee EA, Park PJ.
Bioinformatics
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Heterogeneity and Clonal Evolution of Acquired PARP Inhibitor Resistance in TP53- and BRCA1-Deficient Cells.
Authors: Färkkilä A, Rodríguez A, Oikkonen J, Gulhan DC, Nguyen H, Domínguez J, Ramos S, Mills CE, Pérez-Villatoro F, Lazaro JB, Zhou J, Clairmont CS, Moreau LA, Park PJ, Sorger PK, Hautaniemi S, Frias S, D'Andrea AD.
Cancer Res
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Cis-regulatory dissection of cone development reveals a broad role for Otx2 and Oc transcription factors.
Authors: Lonfat N, Wang S, Lee C, Garcia M, Choi J, Park PJ, Cepko C.
Development
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Essential histone chaperones collaborate to regulate transcription and chromatin integrity.
Authors: Viktorovskaya O, Chuang J, Jain D, Reim NI, López-Rivera F, Murawska M, Spatt D, Churchman LS, Park PJ, Winston F.
Genes Dev
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Negative elongation factor regulates muscle progenitor expansion for efficient myofiber repair and stem cell pool repopulation.
Authors: Robinson DCL, Ritso M, Nelson GM, Mokhtari Z, Nakka K, Bandukwala H, Goldman SR, Park PJ, Mounier R, Chazaud B, Brand M, Rudnicki MA, Adelman K, Dilworth FJ.
Dev Cell
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Resources and challenges for integrative analysis of nuclear architecture data.
Authors: Jung YL, Kirli K, Alver BH, Park PJ.
Curr Opin Genet Dev
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Author Correction: The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing.
Authors: Rodin RE, Dou Y, Kwon M, Sherman MA, D'Gama AM, Doan RN, Rento LM, Girskis KM, Bohrson CL, Kim SN, Nadig A, Luquette LJ, Gulhan DC, Park PJ, Walsh CA.
Nat Neurosci
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