Peter Park

Peter Park, PhD

Professor of Biomedical Informatics
Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street, Boston, MA 02115

Park Lab

Dr. Park is a Professor of Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics PhD program. His research group specializes in computational and statistical analysis of large-scale DNA sequencing data to understand genetic and epigenetic mechanisms related to disease processes. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for identifying and interpreting genomic alterations in the human genome, especially those from cancer patients. His group has made major contributions to many consortium projects such as The Cancer Genome Atlas (TCGA), Encyclopedia of DNA Elements (ENCODE), and Brain Somatic Mosaicism Network, and 4D Nucleome, and Somatic Mosaicism across Human Tissues (SMaHT). His work has been funded by the National Institutes of Health, Cancer Research UK Grand Challenges, The Mark Foundation for Cancer Research, Simons Foundation, Chan Zucherberg Initiative, Blavatnik Therapeutics Challenge, the HMS Quadrangle Fund for Advancing and Seeding Translational Research (Q-FASTR), and others.


DBMI Research Areas
DBMI Courses
The Common Fund Data Ecosystem (CFDE).
Authors: Jurgens JA, Bueckle A, Vora J, Maurya MR, Ahooyi TM, Zheng E, Stear B, Wang D, Ree C, Ramachandran S, Nekrutenko A, Brandes M, Thaker S, Katz DH, Munoz-Torres MC, Diamant I, Chun HE, Simmons JA, Tasian SK, Jenkins SL, Evangelista JE, Dodia H, Saha S, Lindquist MA, Gajjala V, Nemarich C, Zhen J, Ross KE, Byrd AI, Shilin A, Metzger VT, Bologa CG, Srinivasan S, Jang D, Kumar P, Taub LD, Levanto MP, Petrosyan V, Anandakrishnan M, Kim M, Clarke DJB, Ivich A, Crichton DJ, Smallen S, Bordelon D, Chen C, Schroeder AJ, Mahabal A, Cao-Berg I, Kim S, Masood D, Yu K, Gaulton KJ, Jimenez-Morales D, Rincon JM, Honick BJ, Wang W, Wu CH, Milosavljevic A, Blood PD, Boline J, Oprea TI, Lambert CG, de Bono B, Park PJ, Silverstein JC, Flannick J, Yang JJ, Grethe JS, Subramaniam S, Tiemeyer M, Clark T, Wheeler MT, Kahn A, Burnette J, Ranzinger R, Schatz MC, Gibson L, Burtt NP, Carson JP, Chen JY, Ping P, Davis S, Taylor DM, Börner K, Dillman A, Bursey K, Ma'ayan A, Mazumder R, Roth ME, Greene CS.
bioRxiv
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GLP1R expression and parkinson's disease and related disorders in GLP-1RA-treated type 2 diabetes.
Authors: Woo KA, Jang Y, Kim HJ, Park PJ.
Brain
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Multiorgan Molecular Landscape of Severe COVID-19 Revealed by Consensus Gene Signatures and RAB8B Targeting.
Authors: Avila JP, Park P, Singh Y, Amaral PP, Castro Í, Ten-Caten F, Schuch V, Gonçalves ANA, Giddaluru J, Morais MCC, Ogava RLT, Lubiana T, de Castro GA, Aquino R, Durão L, Martins JR, Jimenez L, Costa-Martins AG, Gonzalez-Dias P, Hirata TDC, Dias TL, Peixe DG, Simizo A, E Silva JCS, Vasconcelos AP, Rodrigues MB, Castelucci BG, Virgillio-da-Silva JV, Menezes L, Moraes-Vieira PM, Cabral-Marques O, Nakaya HI.
J Med Virol
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Telomerase mRNA-Lipid nanoparticles attenuate neuroinflammation after traumatic brain injury in mice.
Authors: Kara G, Holcomb M, Tiwari A, Flinn H, Eimer T, Marshall A, Burke M, Park P, Court KA, Cooke JP, Godin B, Villapol S.
Neurotherapeutics
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Efficient near-telomere-to-telomere assembly of nanopore simplex reads.
Authors: Cheng H, Qu H, McKenzie S, Lawrence KR, Windsor R, Vella M, Park PJ, Li H.
Nature
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Lipid Nanoparticle Database towards structure-function modeling and data-driven design for nucleic acid delivery.
Authors: Collins E, Ji J, Kim SG, Witten J, Kim S, Zhu R, Park P, Jung M, Park A, Manan RS, Rudra A, Keum G, Bang EK, Jin JO, Jeang WJ, Langer R, Anderson DG, Im W.
Nat Commun
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Case Report: Looks can deceive: acute postoperative progressive renal dysfunction and hyperkalemia without significant hydronephrosis.
Authors: Lahiji R, Yildirim A, Luke W, Storino Ramacciotti L, Morton EA, Helman TA, Nguyen J, Grajales V, Joshi SS, Narayan VM, Nabavizadeh B, Hajiha M, Nabavizadeh R, Park PJ, Ogan K, Bilen MA, Master VA.
Front Oncol
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Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation.
Authors: Kanellos G, Giacomelli C, Raven A, Vlahov N, Jin H, Herviou P, Malla SB, Nasreddin N, Centeno PP, Alexandrou C, Gilroy K, Baird RL, Pennel K, Munro J, Waldron JA, Hall H, Officer-Jones L, Bryson S, Strathdee D, Lilla S, Zanivan S, Morrison V, Nixon C, Ridgway RA, Miller C, Knight JRP, Campbell AD, Dunne PD, Le Quesne J, Edwards J, Park PJ, Bushell M, Sansom OJ.
Nat Genet
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An integrated view of the structure and function of the human 4D nucleome.
Authors: Dekker J, Oksuz BA, Zhang Y, Wang Y, Minsk MK, Kuang S, Yang L, Gibcus JH, Krietenstein N, Rando OJ, Xu J, Janssens DH, Henikoff S, Kukalev A, Andréa W, Winick-Ng W, Kempfer R, Pombo A, Yu M, Kumar P, Zhang L, Belmont AS, Sasaki T, van Schaik T, Brueckner L, Peric-Hupkes D, van Steensel B, Wang P, Chai H, Kim M, Ruan Y, Zhang R, Quinodoz SA, Bhat P, Guttman M, Zhao W, Chien S, Liu Y, Venev SV, Plewczynski D, Azcarate II, Szabó D, Thieme CJ, Szczepinska T, Chilinski M, Sengupta K, Conte M, Esposito A, Abraham A, Zhang R, Wang Y, Wen X, Wu Q, Yang Y, Liu J, Boninsegna L, Yildirim A, Zhan Y, Chiariello AM, Bianco S, Lee L, Hu M, Li Y, Barnett RJ, Cook AL, Emerson DJ, Marchal C, Zhao P, Park PJ, Alver BH, Schroeder AJ, Navelkar R, Bakker C, Ronchetti W, Ehmsen S, Veit AD, Gehlenborg N, Wang T, Li D, Wang X, Nicodemi M, Ren B, Zhong S, Phillips-Cremins JE, Gilbert DM, Pollard KS, Alber F, Ma J, Noble WS, Yue F.
Nature
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Hepatic zonation determines tumorigenic potential of mutant ß-catenin.
Authors: Raven A, Gilroy K, Jin H, Waldron JA, Leslie H, Munro J, Hall H, Ridgway RA, Ford CA, Gulhan DC, Vlahov N, Mills ML, Hartley A, Anderson E, Bryson S, Sphyris N, Müller M, May S, Cadden B, Nixon C, Waddell SH, Guest R, Boulter L, Barker N, Clevers H, Zhu H, Ivaska J, Strathdee D, Miller CJ, Jamieson NB, Bushell M, Park PJ, Bird TG, Sansom OJ.
Nature
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