Peter Park

Peter Park, PhD

Professor of Biomedical Informatics
Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street, Boston, MA 02115

Park Lab

Dr. Park is a Professor of Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics PhD program. His research group specializes in computational and statistical analysis of large-scale DNA sequencing data to understand genetic and epigenetic mechanisms related to disease processes. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for identifying and interpreting genomic alterations in the human genome, especially those from cancer patients. His group has made major contributions to many consortium projects such as The Cancer Genome Atlas (TCGA), Encyclopedia of DNA Elements (ENCODE), and Brain Somatic Mosaicism Network, and 4D Nucleome, and Somatic Mosaicism across Human Tissues (SMaHT). His work has been funded by the National Institutes of Health, Cancer Research UK Grand Challenges, The Mark Foundation for Cancer Research, Simons Foundation, Chan Zucherberg Initiative, Blavatnik Therapeutics Challenge, the HMS Quadrangle Fund for Advancing and Seeding Translational Research (Q-FASTR), and others.


DBMI Research Areas
DBMI Courses
Case Report: Looks can deceive: acute postoperative progressive renal dysfunction and hyperkalemia without significant hydronephrosis.
Authors: Lahiji R, Yildirim A, Luke W, Storino Ramacciotti L, Morton EA, Helman TA, Nguyen J, Grajales V, Joshi SS, Narayan VM, Nabavizadeh B, Hajiha M, Nabavizadeh R, Park PJ, Ogan K, Bilen MA, Master VA.
Front Oncol
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Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation.
Authors: Kanellos G, Giacomelli C, Raven A, Vlahov N, Jin H, Herviou P, Malla SB, Nasreddin N, Centeno PP, Alexandrou C, Gilroy K, Baird RL, Pennel K, Munro J, Waldron JA, Hall H, Officer-Jones L, Bryson S, Strathdee D, Lilla S, Zanivan S, Morrison V, Nixon C, Ridgway RA, Miller C, Knight JRP, Campbell AD, Dunne PD, Le Quesne J, Edwards J, Park PJ, Bushell M, Sansom OJ.
Nat Genet
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An integrated view of the structure and function of the human 4D nucleome.
Authors: Dekker J, Oksuz BA, Zhang Y, Wang Y, Minsk MK, Kuang S, Yang L, Gibcus JH, Krietenstein N, Rando OJ, Xu J, Janssens DH, Henikoff S, Kukalev A, Andréa W, Winick-Ng W, Kempfer R, Pombo A, Yu M, Kumar P, Zhang L, Belmont AS, Sasaki T, van Schaik T, Brueckner L, Peric-Hupkes D, van Steensel B, Wang P, Chai H, Kim M, Ruan Y, Zhang R, Quinodoz SA, Bhat P, Guttman M, Zhao W, Chien S, Liu Y, Venev SV, Plewczynski D, Azcarate II, Szabó D, Thieme CJ, Szczepinska T, Chilinski M, Sengupta K, Conte M, Esposito A, Abraham A, Zhang R, Wang Y, Wen X, Wu Q, Yang Y, Liu J, Boninsegna L, Yildirim A, Zhan Y, Chiariello AM, Bianco S, Lee L, Hu M, Li Y, Barnett RJ, Cook AL, Emerson DJ, Marchal C, Zhao P, Park PJ, Alver BH, Schroeder AJ, Navelkar R, Bakker C, Ronchetti W, Ehmsen S, Veit AD, Gehlenborg N, Wang T, Li D, Wang X, Nicodemi M, Ren B, Zhong S, Phillips-Cremins JE, Gilbert DM, Pollard KS, Alber F, Ma J, Noble WS, Yue F.
Nature
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Hepatic zonation determines tumorigenic potential of mutant ß-catenin.
Authors: Raven A, Gilroy K, Jin H, Waldron JA, Leslie H, Munro J, Hall H, Ridgway RA, Ford CA, Gulhan DC, Vlahov N, Mills ML, Hartley A, Anderson E, Bryson S, Sphyris N, Müller M, May S, Cadden B, Nixon C, Waddell SH, Guest R, Boulter L, Barker N, Clevers H, Zhu H, Ivaska J, Strathdee D, Miller CJ, Jamieson NB, Bushell M, Park PJ, Bird TG, Sansom OJ.
Nature
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Telomerase mRNA-Lipid nanoparticles attenuate neuroinflammation after traumatic brain injury in mice.
Authors: Kara G, Holcomb M, Tiwari A, Flinn H, Eimer T, Marshall A, Burke M, Park P, Court K, Cooke JP, Godin B, Villapol S.
bioRxiv
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Benchmarking of duplex sequencing approaches to reveal somatic mutation landscapes.
Authors: Zhang Y, Viswanadham VV, Andreopoulos M, Glodzik D, Liu R, Luquette LJ, Jo SY, Narayan A, Niu M, Anderson L, Brew JA, Chao H, Cibulskis C, Dong G, Evani US, Feng WC, Gronska-Peski M, Helland A, Hilal N, Jabara NT, Jin H, Li N, Manam MD, Mallett SL, Runnels A, Scharlee C, Smith C, Shao D, Walsh CA, Adalsteinsson VA, Lee EA, Park PJ, Ardlie KG, Germer S, Gibbs RA, Choudhury S, Doddapaneni HV, Evrony GD, Zong C, Coorens THH.
bioRxiv
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Dynamic data-driven management of atrial fibrillation with implantable cardiac monitors: The MONITOR AF study.
Authors: Katapadi A, Chelikam N, Garg J, Gopinathannair R, Park P, Darden D, Pothineni NVK, Atkins D, Kabra R, Bommana S, Chung M, DiBiase L, Natale A, Lakkireddy D.
Heart Rhythm
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Combined somatic mutation and transcriptome analysis reveals region-specific differences in clonal architecture in human cortex.
Authors: Viswanadham VV, Kim SN, Caglayan E, Doan RN, Dou Y, Bizzotto S, Khoshkhoo S, Huang AY, Yeh R, Chhouk BH, Truong A, Chappell KM, Beaudin M, Barton A, Akula SK, Zhao Y, Rento L, Lodato M, Szeto RA, Ganz J, Li P, Tsai JW, Hill RS, Park PJ, Walsh CA.
Cell Rep
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Efficient near telomere-to-telomere assembly of Nanopore Simplex reads.
Authors: Cheng H, Qu H, McKenzie S, Lawrence KR, Windsor R, Vella M, Park PJ, Li H.
bioRxiv
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A comprehensive view of somatic mosaicism by single-cell DNA analysis.
Authors: Luquette LJ, Coorens THH, Natu A, Suvakov M, Caplin A, Jun MS, Mo A, Pelt J, Anderson L, Berselli M, Bhamidipati S, Blanchard T, Brew J, Chun HE, Chun H, Dehankar MK, Feng WC, Furatero R, Grochowski CM, Ho E, Jang Y, Kottapalli K, Leonard MK, Lim NS, Lindsay T, Nicholson S, Raimondi I, Runnels A, Scharlee C, Shin J, Veit AD, VonDran M, Wang Y, Yuan DJ, Zhao Y, Bell TJ, Ardlie K, Doddapaneni H, Fulton R, Germer S, Landau D, Oh JW, Park PJ, Vaccarino FM, Walsh C, Abyzov A.
bioRxiv
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