Peter Park

Peter Park, PhD

Professor of Biomedical Informatics
Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street, Boston, MA 02115

Park Lab

Dr. Park is a Professor of Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics PhD program. His research group specializes in computational and statistical analysis of large-scale DNA sequencing data to understand genetic and epigenetic mechanisms related to disease processes. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for identifying and interpreting genomic alterations in the human genome, especially those from cancer patients. His group has made major contributions to many consortium projects such as The Cancer Genome Atlas (TCGA), Encyclopedia of DNA Elements (ENCODE), and Brain Somatic Mosaicism Network, and 4D Nucleome, and Somatic Mosaicism across Human Tissues (SMaHT). His work has been funded by the National Institutes of Health, Cancer Research UK Grand Challenges, The Mark Foundation for Cancer Research, Simons Foundation, Chan Zucherberg Initiative, Blavatnik Therapeutics Challenge, the HMS Quadrangle Fund for Advancing and Seeding Translational Research (Q-FASTR), and others.


DBMI Research Areas
DBMI Courses
Telomerase mRNA-Lipid nanoparticles attenuate neuroinflammation after traumatic brain injury in mice.
Authors: Kara G, Holcomb M, Tiwari A, Flinn H, Eimer T, Marshall A, Burke M, Park P, Court K, Cooke JP, Godin B, Villapol S.
bioRxiv
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Benchmarking of duplex sequencing approaches to reveal somatic mutation landscapes.
Authors: Zhang Y, Viswanadham VV, Andreopoulos M, Glodzik D, Liu R, Luquette LJ, Jo SY, Narayan A, Niu M, Anderson L, Brew JA, Chao H, Cibulskis C, Dong G, Evani US, Feng WC, Gronska-Peski M, Helland A, Hilal N, Jabara NT, Jin H, Li N, Manam MD, Mallett SL, Runnels A, Scharlee C, Smith C, Shao D, Walsh CA, Adalsteinsson VA, Lee EA, Park PJ, Ardlie KG, Germer S, Gibbs RA, Choudhury S, Doddapaneni HV, Evrony GD, Zong C, Coorens THH.
bioRxiv
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Dynamic data-driven management of atrial fibrillation with implantable cardiac monitors: The MONITOR AF study.
Authors: Katapadi A, Chelikam N, Garg J, Gopinathannair R, Park P, Darden D, Pothineni NVK, Atkins D, Kabra R, Bommana S, Chung M, DiBiase L, Natale A, Lakkireddy D.
Heart Rhythm
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Combined somatic mutation and transcriptome analysis reveals region-specific differences in clonal architecture in human cortex.
Authors: Viswanadham VV, Kim SN, Caglayan E, Doan RN, Dou Y, Bizzotto S, Khoshkhoo S, Huang AY, Yeh R, Chhouk BH, Truong A, Chappell KM, Beaudin M, Barton A, Akula SK, Zhao Y, Rento L, Lodato M, Szeto RA, Ganz J, Li P, Tsai JW, Hill RS, Park PJ, Walsh CA.
Cell Rep
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Efficient near telomere-to-telomere assembly of Nanopore Simplex reads.
Authors: Cheng H, Qu H, McKenzie S, Lawrence KR, Windsor R, Vella M, Park PJ, Li H.
bioRxiv
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A comprehensive view of somatic mosaicism by single-cell DNA analysis.
Authors: Luquette LJ, Coorens THH, Natu A, Suvakov M, Caplin A, Jun MS, Mo A, Pelt J, Anderson L, Berselli M, Bhamidipati S, Blanchard T, Brew J, Chun HE, Chun H, Dehankar MK, Feng WC, Furatero R, Grochowski CM, Ho E, Jang Y, Kottapalli K, Leonard MK, Lim NS, Lindsay T, Nicholson S, Raimondi I, Runnels A, Scharlee C, Shin J, Veit AD, VonDran M, Wang Y, Yuan DJ, Zhao Y, Bell TJ, Ardlie K, Doddapaneni H, Fulton R, Germer S, Landau D, Oh JW, Park PJ, Vaccarino FM, Walsh C, Abyzov A.
bioRxiv
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Diploid donor-specific assembly enhances somatic structural variant detection in cancer genomes.
Authors: Zhang Y, Qu H, Qin Q, Li H, Park PJ.
bioRxiv
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Systematic artifacts from Illumina two-color chemistry confound variant identification and actionability in clinical panels.
Authors: Jin H, Andreopoulos M, Viswanadham VV, Park PJ.
medRxiv
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The Data Distillery: A Graph Framework for Semantic Integration and Querying of Biomedical Data.
Authors: Ahooyi TM, Stear B, Simmons JA, Metzger VT, Kumar P, Evangelista JE, Clarke DJB, Xie Z, Kim H, Jenkins SL, Maurya MR, Ramachandran S, Fahy E, Gillespie TH, Imam FT, Kokash N, Roth ME, Fullem R, Jevtic D, Mihajlovic A, Tiemeyer M, Bakker C, Schroeder AJ, Markowski J, Nedzel J, Hill DD, Terry J, Nemarich C, Boline J, Park PJ, Ardlie KG, Vora J, Mazumder R, Ranzinger R, de Bono B, Subramaniam S, Grethe JS, Yang JJ, Lambert CG, Resnick A, Milosavljevic A, Ma'ayan A, Silverstein JC, Taylor DM.
bioRxiv
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Comprehensive benchmarking of somatic single-nucleotide variant and indel detection at ultra-low allele fractions using short- and long-read data.
Authors: Jiny Ha YJ, Maziec D, Markowski J, Georges SJ, Parmalee NL, Berselli M, Coorens THH, Dong S, Gardiner S, Kalra D, Li D, Miao B, Musunuri R, Xue L, Yu Z, Walker K, Anderson L, Au NYT, Cibulskis C, Doddapaneni H, Grochowski CM, Jensen DM, Lindsay T, Loy K, Narayan A, Narzisi G, Ou J, Pham MM, Runnels AM, Stergachis AB, Sutherlin LM, Wang T, Jin H, Feng WC, Zhang Y, Veit AD, TaeHee Kim C, Chun HE, Ardlie K, Fulton RS, Germer S, Gibbs R, Marth GT, Bennett JT, Park PJ.
bioRxiv
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