Accelerating biomedical discovery in the 21st century by enabling access and joint analysis of diverse data types (from genetic variants, to imaging studies to clinical notes) at an unprecedented pace. The infrastructure must not only enable acceleration of prior analyses but do so for a much wider range of researchers from disciplines that previously did not have the means to engage in this research. More important than acceleration is to ensure that the wishes of the patient, as to who may access their data and when, remains the primary informant of all infrastructure design. It’s their data.