Robert Gentleman

Robert Gentleman, PhD

Executive Director, Center for Computational Biomedicine
Professor of the Practice in the Department of Biomedical Informatics

Robert Gentleman is the founding executive director of Harvard Medical School’s Center for Computational Biomedicine. An accomplished statistician and bioinformatician, Dr. Gentleman is one of the creators of the R programming language and a founder of the Bioconductor project, an open-source collaborative software tool to promote statistical analysis of biological data. He has served as vice president of 23andMe, where he helped launch their therapeutic division, and as senior director for bioinformatics and computational biology at Genentech. He was head of computational biology at the Fred Hutchinson Cancer Research Center and held academic positions at Harvard University, University of Auckland and the University of Waterloo. Dr. Gentleman’s research interests are related to genomics, machine learning, data visualization, and the application of statistical and computational methods to study human disease.

Genetic and epigenetic determinants of neurogenesis and myogenesis.
Authors: Fong AP, Yao Z, Zhong JW, Cao Y, Ruzzo WL, Gentleman RC, Tapscott SJ.
Dev Cell
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The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients.
Authors: Jiang Z, Jhunjhunwala S, Liu J, Haverty PM, Kennemer MI, Guan Y, Lee W, Carnevali P, Stinson J, Johnson S, Diao J, Yeung S, Jubb A, Ye W, Wu TD, Kapadia SB, de Sauvage FJ, Gentleman RC, Stern HM, Seshagiri S, Pant KP, Modrusan Z, Ballinger DG, Zhang Z.
Genome Res
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DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy.
Authors: Geng LN, Yao Z, Snider L, Fong AP, Cech JN, Young JM, van der Maarel SM, Ruzzo WL, Gentleman RC, Tawil R, Tapscott SJ.
Dev Cell
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Querying genomic databases: refining the connectivity map.
Authors: Segal MR, Xiong H, Bengtsson H, Bourgon R, Gentleman R.
Stat Appl Genet Mol Biol
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An integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcription.
Authors: Knouf EC, Garg K, Arroyo JD, Correa Y, Sarkar D, Parkin RK, Wurz K, O'Briant KC, Godwin AK, Urban ND, Ruzzo WL, Gentleman R, Drescher CW, Swisher EM, Tewari M.
Nucleic Acids Res
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Analyzing biological data using R: methods for graphs and networks.
Authors: Le Meur N, Gentleman R.
Methods Mol Biol
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Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages.
Authors: Palii CG, Perez-Iratxeta C, Yao Z, Cao Y, Dai F, Davison J, Atkins H, Allan D, Dilworth FJ, Gentleman R, Tapscott SJ, Brand M.
EMBO J
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Towards BioDBcore: a community-defined information specification for biological databases.
Authors: Gaudet P, Bairoch A, Field D, Sansone SA, Taylor C, Attwood TK, Bateman A, Blake JA, Bult CJ, Cherry JM, Chisholm RL, Cochrane G, Cook CE, Eppig JT, Galperin MY, Gentleman R, Goble CA, Gojobori T, Hancock JM, Howe DG, Imanishi T, Kelso J, Landsman D, Lewis SE, Karsch Mizrachi I, Orchard S, Ouellette BF, Ranganathan S, Richardson L, Rocca-Serra P, Schofield PN, Smedley D, Southan C, Tan TW, Tatusova T, Whetzel PL, White O, Yamasaki C.
Database (Oxford)
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Identification of aberrant pathway and network activity from high-throughput data.
Authors: Ochs MF, Karchin R, Ressom H, Gentleman R.
Pac Symp Biocomput
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Towards BioDBcore: a community-defined information specification for biological databases.
Authors: Gaudet P, Bairoch A, Field D, Sansone SA, Taylor C, Attwood TK, Bateman A, Blake JA, Bult CJ, Cherry JM, Chisholm RL, Cochrane G, Cook CE, Eppig JT, Galperin MY, Gentleman R, Goble CA, Gojobori T, Hancock JM, Howe DG, Imanishi T, Kelso J, Landsman D, Lewis SE, Mizrachi IK, Orchard S, Ouellette BF, Ranganathan S, Richardson L, Rocca-Serra P, Schofield PN, Smedley D, Southan C, Tan TW, Tatusova T, Whetzel PL, White O, Yamasaki C.
Nucleic Acids Res
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