Peter Kharchenko

Peter Vasili Kharchenko, Ph.D.

Associate Professor of Biomedical Informatics

Kharchenko Lab

Phone:

617/432-7377

Fax:

617/432-0693

Peter_Kharchenko@hms.harvard.edu

Tabs

Research

Peter Kharchenko received a PhD in biophysics at Harvard University, studying gene regulation and metabolic networks under the advisement of George Church. He then completed a four-year postdoctoral fellowship in computational biology and genomics in the laboratory of Peter Park. He is currently studying the epigenetic mechanisms that regulate the growth and maintenance of normal tissues as well as the disruptions of the epigenetic state that contribute to a variety of disorders.

Publications

RNA velocity of single cells.

Ruslan A Soldatov, Ph.D., Peter Vasili Kharchenko, Ph.D.

Nature, August 8, 2018

La Manno G, Soldatov R, Zeisel A, Braun E, Hochgerner H, Petukhov V, Lidschreiber K, Kastriti ME, Lönnerberg P, Furlan A, Fan J, Borm LE, Liu Z, van Bruggen D, Guo J, He X, Barker R, Sundström E, Castelo-Branco G, Cramer P, Adameyko I, Linnarsson S,...

Link to abstract on PubMed

dropEst: pipeline for accurate estimation of molecular counts in droplet-based single-cell RNA-seq experiments.

Peter Vasili Kharchenko, Ph.D.

Genome biology, June 19, 2018

Petukhov V, Guo J, Baryawno N, Severe N, Scadden DT, Samsonova MG, Kharchenko PV

Link to abstract on PubMed

Linking transcriptional and genetic tumor heterogeneity through allele analysis of single-cell RNA-seq data.

Peter J. Park, Ph.D., Peter Vasili Kharchenko, Ph.D.

Genome research, June 13, 2018

Fan J, Lee HO, Lee S, Ryu DE, Lee S, Xue C, Kim SJ, Kim K, Barkas N, Park PJ, Park WY, Kharchenko PV

Link to abstract on PubMed

Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain.

Peter Vasili Kharchenko, Ph.D.

Nature biotechnology, December 11, 2017

Lake BB, Chen S, Sos BC, Fan J, Kaeser GE, Yung YC, Duong TE, Gao D, Chun J, Kharchenko PV, Zhang K

Link to abstract on PubMed

Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell.

Peter Vasili Kharchenko, Ph.D.

Cell, December 7, 2017

Hoggatt J, Singh P, Tate TA, Chou BK, Datari SR, Fukuda S, Liu L, Kharchenko PV, Schajnovitz A, Baryawno N, Mercier FE, Boyer J, Gardner J, Morrow DM, Scadden DT, Pelus LM

Link to abstract on PubMed

A comparative strategy for single-nucleus and single-cell transcriptomes confirms accuracy in predicted cell-type expression from nuclear RNA.

Peter Vasili Kharchenko, Ph.D.

Scientific reports, July 20, 2017

Lake BB, Codeluppi S, Yung YC, Gao D, Chun J, Kharchenko PV, Linnarsson S, Zhang K

Link to abstract on PubMed

Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla.

Peter Vasili Kharchenko, Ph.D.

Science (New York, N.Y.), July 7, 2017

Furlan A, Dyachuk V, Kastriti ME, Calvo-Enrique L, Abdo H, Hadjab S, Chontorotzea T, Akkuratova N, Usoskin D, Kamenev D, Petersen J, Sunadome K, Memic F, Marklund U, Fried K, Topilko P, Lallemend F, Kharchenko PV, Ernfors P, Adameyko I

Link to abstract on PubMed

Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia.

Cheng-Zhong Zhang, Ph.D., Peter Vasili Kharchenko, Ph.D.

Genome research, July 5, 2017

Wang L, Fan J, Francis JM, Georghiou G, Hergert S, Li S, Gambe R, Zhou CW, Yang C, Xiao S, Cin PD, Bowden M, Kotliar D, Shukla SA, Brown JR, Neuberg D, Alessi DR, Zhang CZ, Kharchenko PV, Livak KJ, Wu CJ

Link to abstract on PubMed

Ectopic protein interactions within BRD4-chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma.

Peter Vasili Kharchenko, Ph.D.

Proceedings of the National Academy of Sciences of the United States of America, May 8, 2017

Alekseyenko AA, Walsh EM, Zee BM, Pakozdi T, Hsi P, Lemieux ME, Dal Cin P, Ince TA, Kharchenko PV, Kuroda MI, French CA

Link to abstract on PubMed

Challenges and emerging directions in single-cell analysis.

Peter Vasili Kharchenko, Ph.D.

Genome biology, May 8, 2017

Yuan GC, Cai L, Elowitz M, Enver T, Fan G, Guo G, Irizarry R, Kharchenko P, Kim J, Orkin S, Quackenbush J, Saadatpour A, Schroeder T, Shivdasani R, Tirosh I

Link to abstract on PubMed

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Contact

Address:

Harvard Medical School

Department of Biomedical Informatics

10 Shattuck St

Boston, MA 02115

Faculty

Instructors

Lecturers

Postdoctoral Fellows

Research Scientists

Technical Staff

Tabs

RNA velocity of single cells.

dropEst: pipeline for accurate estimation of molecular counts in droplet-based single-cell RNA-seq experiments.

Linking transcriptional and genetic tumor heterogeneity through allele analysis of single-cell RNA-seq data.

Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain.

Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell.

A comparative strategy for single-nucleus and single-cell transcriptomes confirms accuracy in predicted cell-type expression from nuclear RNA.

Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla.

Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia.

Ectopic protein interactions within BRD4-chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma.

Challenges and emerging directions in single-cell analysis.