Isaac S. Kohane, MD, PhD
Professor and Chair, Department of Biomedical Informatics
Professor of Pediatrics, Boston Children's Hospital
10 Shattuck Street
Boston, MA 02115
Over the last 30 years, Isaac Kohane's research agenda has been driven by the vision of what biomedical researchers could do to find new cures, provide new diagnoses and deliver the best care available if data could be converted more rapidly to knowledge and knowledge to practice. In so doing, Kohane has designed and led multiple internationally adopted efforts to “instrument" the healthcare enterprise for discovery (see i2b2) and to enable innovative decision-making tools to be applied to the point of care (see SMART). At the same time, the new insights afforded by 'omic-scale molecular analyses have inspired him and his collaborators to work on re-characterizing and reclassifying diseases such as autism (see here and here), rheumatoid arthritis and cancers. In many of these studies, the developmental trajectories of thousands of genes have been a powerful tool in unraveling complex diseases (e.g., here and here). Kohane currently leads three NIH-funded projects that cut across the entire agenda:
- A Center for Excellence in Genomic Science to study neuropsychiatric disease at multiple levels (from molecular characterization of induced neurons obtained from fibroblasts of patients to automated classification of the textual component of their electronic medical record).
- The Coordinating Center for the Undiagnosed Diseases Network. Where patients with rare and unknown diseases are provided with combined clinical and molecular diagnoses in a nationally-scaled infrastructure so that they can see the right expert with all their relevant data at hand.
- A Center for Excellence in Big Data to Knowledge to both create a nationally scaleable research data-sharing infrastructure and demonstrate its use for neurodevelopmental diseases.
Kohane is always on the look out for like-minded “quants” who share the same goals to bring a better future for medicine and biomedical science to the present.
Susanne E. Churchill, PhD
Executive Director, Department of Biomedical Informatics
10 Shattuck Street
Boston, MA 02115
Susanne Churchill received her PhD from Boston University School of Medicine and did her postdoctoral training at Harvard Medical School in the field of cardiovascular and renal physiology, progressing to instructor and lecturer. She co-founded the Institute for Circadian Physiology in Boston where she served as chief operating officer while continuing her research in space medicine and teaching. She returned full time to HMS to serve as director of sponsored programs administration and subsequently was appointed associate dean for research. Churchill next joined forces with Kohane to lead the successful Informatics for Integrating Biology and the Bedside (i2b2) National Center for Biomedical Computing at Partners HealthCare as its executive director and principle investigator of the educational core. She joined DBMI in 2015 as executive director of the department, executive director of the Big Data to Knowledge (BD2K) Center of Excellence, executive director of the N-GRID (neuropsychiatric genome-scale and RDoC-Individualized domains) Center of Excellence in Genome Science and program director for the long running Summer Institute in Biomedical Informatics. Churchill is also an instructor in the Channing Division of Network Medicine at Brigham and Women's Hospital.