Maha Farhat

Maha Farhat, MD, MSc

Gilbert S. Omenn Associate Professor of Biomedical Informatics
Associate Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street #307, Boston, MA 02115

Maha Farhat  holds an MD from the McGill University Faculty of Medicine and a MSc in biostatistics from the Harvard Chan School of Public Health. She is also a practicing physician at the Massachusetts General Hospital Division of Pulmonary and Critical Care Medicine.

Dr. Farhat's research focuses on the development and application of methods for associating genotype and phenotype in infectious disease pathogens, with a strong emphasis on translation to better diagnostics and surveillance in resource-poor settings. To date, Farhat's work has focused on the pathogen Mycobacterium tuberculosis and spans the spectrum from computational analysis to field studies. She is PI and Co-Investigator on several large projects funded by NIH including the NIAID and the BD2K initiative.


DBMI Research Areas
Differential rates of Mycobacterium tuberculosis transmission associate with host-pathogen sympatry.
Authors: Gröschel MI, Pérez-Llanos FJ, Diel R, Vargas R, Escuyer V, Musser K, Trieu L, Meissner JS, Knorr J, Klinkenberg D, Kouw P, Homolka S, Samek W, Mathema B, van Soolingen D, Niemann S, Ahuja SD, Farhat MR.
Nat Microbiol
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Exploring gene content with pangene graphs.
Authors: Li H, Marin M, Farhat MR.
Bioinformatics
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A composite reference standard is needed for bedaquiline antimicrobial susceptibility testing for Mycobacterium tuberculosis complex.
Authors: Köser CU, Miotto P, Ismail N, Anthony RM, Utpatel C, Merker M, Niemann S, Tahseen S, Rigouts L, Rodrigues C, Omar SV, Farhat MR, Antonenka U, Hoffmann H, Cirillo DM, Schön T.
Eur Respir J
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Single nucleotide variation catalog from clinical isolates mapped on tertiary and quaternary structures of ESX-1-related proteins reveals critical regions as putative Mtb therapeutic targets.
Authors: Tzfadia O, Gijsbers A, Vujkovic A, Snobre J, Vargas R, Dewaele K, Meehan CJ, Farhat M, Hakke S, Peters PJ, de Jong BC, Siroy A, Ravelli RBG.
Microbiol Spectr
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MmpR5 protein truncation and bedaquiline resistance in Mycobacterium tuberculosis isolates from South Africa: a genomic analysis.
Authors: Roberts LW, Malone KM, Hunt M, Joseph L, Wintringer P, Knaggs J, Crook D, Farhat MR, Iqbal Z, Omar SV.
Lancet Microbe
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Identification of bacterial determinants of tuberculosis infection and treatment outcomes: a phenogenomic analysis of clinical strains.
Authors: Stanley S, Spaulding CN, Liu Q, Chase MR, Ha DTM, Thai PVK, Lan NH, Thu DDA, Quang NL, Brown J, Hicks ND, Wang X, Marin M, Howard NC, Vickers AJ, Karpinski WM, Chao MC, Farhat MR, Caws M, Dunstan SJ, Thuong NTT, Fortune SM.
Lancet Microbe
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Drug resistance and epidemiological success of modern Mycobacterium tuberculosis lineages in western India.
Authors: Dixit A, Ektefaie Y, Kagal A, Freschi L, Karyakarte R, Lokhande R, Groschel M, Tornheim JA, Gupte N, Pradhan NN, Paradkar MS, Deshmukh S, Kadam D, Schito M, Engelthaler DM, Gupta A, Golub J, Mave V, Farhat M.
J Infect Dis
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Implications of Race Adjustment in Lung-Function Equations.
Authors: Diao JA, He Y, Khazanchi R, Nguemeni Tiako MJ, Witonsky JI, Pierson E, Rajpurkar P, Elhawary JR, Melas-Kyriazi L, Yen A, Martin AR, Levy S, Patel CJ, Farhat M, Borrell LN, Cho MH, Silverman EK, Burchard EG, Manrai AK.
N Engl J Med
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For Tuberculosis, Not "To Screen or Not to Screen?" but "Who?" and "How?"
Authors: Farhat MR, Jacobson KR.
Clin Infect Dis
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Precision Phenotyping for Curating Research Cohorts of Patients with Post-Acute Sequelae of COVID-19 (PASC) as a Diagnosis of Exclusion.
Authors: Azhir A, Hügel J, Tian J, Cheng J, Bassett IV, Bell DS, Bernstam EV, Farhat MR, Henderson DW, Lau ES, Morris M, Semenov YR, Triant VA, Visweswaran S, Strasser ZH, Klann JG, Murphy SN, Estiri H.
medRxiv
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