Shamil Sunyaev

Shamil Sunyaev, PhD

Professor of Biomedical Informatics, Harvard Medical School
Professor of Medicine, Brigham and Women’s Hospital

10 Shattuck Street, Room 311A, Boston, MA 02115

Shamil Sunyaev is a computational genomicist and geneticist. Research in his lab encompasses many aspects of population genetic variation including the origin of mutations, the effect of allelic variants on molecular function, population and evolutionary genetics, and genetics of human complex and Mendelian traits. He developed several computational and statistical methods widely adopted by the community. Sunyaev obtained a PhD in molecular biophysics from the Moscow Institute of Physics and Technology and completed his postdoctoral training in bioinformatics at the European Molecular Biology Laboratory (EMBL). He is an Institute Member at Broad Institute of MIT and Harvard. He also co-organizes the Boston Evolutionary Genomics Supergroup.


DBMI Research Areas
DBMI Courses
Missing Regulation Between Genetic Association and Transcriptional Abundance for Hypercholesterolemia Genes.
Authors: Hakim A, Connally NJ, Schnitzler GR, Cho MH, Jiang ZG, Sunyaev SR, Gupta RM.
Genes (Basel)
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Inherent instability of simple DNA repeats shapes an evolutionarily stable distribution of repeat lengths.
Authors: McGinty RJ, Balick DJ, Mirkin SM, Sunyaev SR.
bioRxiv
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NERINE reveals rare variant associations in gene networks across multiple phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson's disease.
Authors: Nazeen S, Wang X, Morrow A, Strom R, Ethier E, Ritter D, Henderson A, Afroz J, Stitziel NO, Gupta RM, Luk K, Studer L, Khurana V, Sunyaev SR.
bioRxiv
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Are complex traits underpinned by polygenic molecular traits? A reflection on the complexity of gene expression.
Authors: Hajheideri M, Sunyaev S, de Meaux J.
Plant Cell Physiol
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Quantifying constraint in the human mitochondrial genome.
Authors: Lake NJ, Ma K, Liu W, Battle SL, Laricchia KM, Tiao G, Puiu D, Ng KK, Cohen J, Compton AG, Cowie S, Christodoulou J, Thorburn DR, Zhao H, Arking DE, Sunyaev SR, Lek M.
Nature
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Somatic mosaicism in schizophrenia brains reveals prenatal mutational processes.
Authors: Maury EA, Jones A, Seplyarskiy V, Nguyen TTL, Rosenbluh C, Bae T, Wang Y, Abyzov A, Khoshkhoo S, Chahine Y, Zhao S, Venkatesh S, Root E, Voloudakis G, Roussos P, Park PJ, Akbarian S, Brennand K, Reilly S, Lee EA, Sunyaev SR, Walsh CA, Chess A.
Science
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Genetic mapping across autoimmune diseases reveals shared associations and mechanisms.
Authors: Lincoln MR, Connally N, Axisa PP, Gasperi C, Mitrovic M, van Heel D, Wijmenga C, Withoff S, Jonkers IH, Padyukov L, Rich SS, Graham RR, Gaffney PM, Langefeld CD, Vyse TJ, Hafler DA, Chun S, Sunyaev SR, Cotsapas C.
Nat Genet
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Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies.
Authors: Nazeen S, Wang X, Zielinski D, Lam I, Hallacli E, Xu P, Ethier E, Strom R, Zanella CA, Nithianandam V, Ritter D, Henderson A, Saurat N, Afroz J, Nutter-Upham A, Benyamini H, Copty J, Ravishankar S, Morrow A, Mitchel J, Neavin D, Gupta R, Farbehi N, Grundman J, Myers RH, Scherzer CR, Trojanowski JQ, Van Deerlin VM, Cooper AA, Lee EB, Erlich Y, Lindquist S, Peng J, Geschwind DH, Powell J, Studer L, Feany MB, Sunyaev SR, Khurana V.
bioRxiv
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Joint, multifaceted genomic analysis enables diagnosis of diverse, ultra-rare monogenic presentations.
Authors: Nadimpalli Kobren S, Moldovan MA, Reimers R, Traviglia D, Li X, Barnum D, Veit A, Willett J, Berselli M, Ronchetti W, Sherwood R, Krier J, Kohane IS, Sunyaev SR.
bioRxiv
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RExPRT: a machine learning tool to predict pathogenicity of tandem repeat loci.
Authors: Fazal S, Danzi MC, Xu I, Kobren SN, Sunyaev S, Reuter C, Marwaha S, Wheeler M, Dolzhenko E, Lucas F, Wuchty S, Tekin M, Züchner S, Aguiar-Pulido V.
Genome Biol
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