Integrated urine proteomics and renal single-cell genomics identify an IFN-? response gradient in lupus nephritis.
IFN- ? and TNF- a drive a CXCL10 + CCL2 + macrophage phenotype expanded in severe COVID-19 and other diseases with tissue inflammation.
Interactions Between Genome-Wide Genetic Factors and Smoking Influencing Risk of Systemic Lupus Erythematosus.
Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements.
Population-specific causal disease effect sizes in functionally important regions impacted by selection.
