Alexa McCray
Alexa McCray, PhD
Professor of Medicine
Principal Investigator, Undiagnosed Diseases Network (UDN)
10 Shattuck Street, Boston, MA 02115

Alexa T. McCray is Professor of Medicine at Harvard Medical School and the Department of Medicine, Beth Israel Deaconess Medical Center. She conducts research on knowledge representation and discovery, with a special focus on the significant problems that persist in the curation, dissemination, and exchange of scientific and clinical information in biomedicine and health.

McCray is the former director of the Lister Hill National Center for Biomedical Communications, an intramural research division of the National Library of Medicine at the National Institutes of Health. While at the NIH, she directed the design and development of a number of national information resources, including ClinicalTrials.gov, Genetics Home Reference, and Profiles in Science. Before joining the NIH she was on the research staff of IBM’s T.J. Watson Research Center. She received the PhD from Georgetown University, and for three years was on the faculty there. She conducted pre-doctoral research at the Massachusetts Institute of Technology. She joined Harvard Medical School in 2005, where she co-founded the Center for Biomedical Informatics, now the Department of Biomedical Informatics. She currently serves as a Principal Investigator of the US-wide Undiagnosed Diseases Network, an NIH research study that seeks to provide answers for patients and families affected by undiagnosed conditions. 

McCray was elected to the National Academy of Medicine in 2001. She is a fellow of the American Association for the Advancement of Science, the American College of Medical Informatics, and the International Academy of Health Sciences Informatics. She is chair of the National Academies of Sciences, Engineering, and Medicine’s (NASEM) Board on Research Data and Information, and she recently chaired a NASEM consensus study entitled Open Science by Design: Realizing a Vision for 21st Century Research.


DBMI Research Areas
On the 80th Birthday of Jan van Bemmel.
Authors: Ball MJ, Bergemann D, Hasman A, Haux R, McCray AT, van der Lei J.
Yearb Med Inform
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Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease.
Authors: Splinter K, Adams DR, Bacino CA, Bellen HJ, Bernstein JA, Cheatle-Jarvela AM, Eng CM, Esteves C, Gahl WA, Hamid R, Jacob HJ, Kikani B, Koeller DM, Kohane IS, Lee BH, Loscalzo J, Luo X, McCray AT, Metz TO, Mulvihill JJ, Nelson SF, Palmer CGS, Phillips JA, Pick L, Postlethwait JH, Reuter C, Shashi V, Sweetser DA, Tifft CJ, Walley NM, Wangler MF, Westerfield M, Wheeler MT, Wise AL, Worthey EA, Yamamoto S, Ashley EA.
N Engl J Med
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Characteristics of undiagnosed diseases network applicants: implications for referring providers.
Authors: Walley NM, Pena LDM, Hooper SR, Cope H, Jiang YH, McConkie-Rosell A, Sanders C, Schoch K, Spillmann RC, Strong K, McCray AT, Mazur P, Esteves C, LeBlanc K, Wise AL, Shashi V.
BMC Health Serv Res
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Medical subdomain classification of clinical notes using a machine learning-based natural language processing approach.
Authors: Weng WH, Wagholikar KB, McCray AT, Szolovits P, Chueh HC.
BMC Med Inform Decis Mak
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On Contributing to the Progress of Medical Informatics as Publisher.
Authors: Haux R, Geissbuhler A, Holmes J, Jaulent MC, Koch S, Kulikowski CA, Lehmann CU, McCray AT, Séroussi B, Soualmia LF, van Bemmel JH.
Yearb Med Inform
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The Undiagnosed Diseases Network: Accelerating Discovery about Health and Disease.
Authors: Ramoni RB, Mulvihill JJ, Adams DR, Allard P, Ashley EA, Bernstein JA, Gahl WA, Hamid R, Loscalzo J, McCray AT, Shashi V, Tifft CJ, Wise AL.
Am J Hum Genet
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Research Strategies for Biomedical and Health Informatics. Some Thought-provoking and Critical Proposals to Encourage Scientific Debate on the Nature of Good Research in Medical Informatics.
Authors: Haux R, Kulikowski CA, Bakken S, de Lusignan S, Kimura M, Koch S, Mantas J, Maojo V, Marschollek M, Martin-Sanchez F, Moen A, Park HA, Sarkar IN, Leong TY, McCray AT.
Methods Inf Med
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Research Strategies for Biomedical and Health Informatics.
Authors: Haux R, Kulikowski CA, Bakken S, de Lusignan S, Kimura M, Koch S, Mantas J, Maojo V, Marschollek M, Martin-Sanchez F, Moen A, Park HA, Neil Sarkar I, Yun Leong T, McCray AT.
Methods Inf Med
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The Renewed Promise of Medical Informatics.
Authors: van Bemmel JH, McCray AT.
Yearb Med Inform
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Health IT vendors and the academic community: The 2014 ACMI debate.
Authors: McCray AT, Glaser J, Koppel R, Langlotz CP, Silverstein J.
J Biomed Inform
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