Aparna Nathan

Aparna Nathan, PhD

Lecturer in Biomedical Informatics
Associate Director, Master of Biomedical Informatics (MBI) Program

Aparna Nathan studies T cell states in the context of infectious and autoimmune diseases through multimodal analysis of single-cell data from disease cohorts. She earned her PhD in Bioinformatics and Integrative Genomics from Harvard University and conducted her thesis research in Soumya Raychaudhuri’s lab. In her graduate work, she identified T cell states associated with tuberculosis progression and rheumatoid arthritis, and developed a single-cell-resolution model of state-dependent expression quantitative trait loci.

Aparna currently teaches and oversees capstone projects in the Master of Biomedical Informatics program. Her current research is focused on leveraging single-cell data to characterize state-dependent regulatory effects of genetic variants implicated in disease.

DBMI Courses
Deep transcriptome sequencing of subgenual anterior cingulate cortex reveals cross-diagnostic and diagnosis-specific RNA expression changes in major psychiatric disorders.
Authors: Akula N, Marenco S, Johnson K, Feng N, Zhu K, Schulmann A, Corona W, Jiang X, Cross J, England B, Nathan A, Detera-Wadleigh S, Xu Q, Auluck PK, An K, Kramer R, Apud J, Harris BT, Harker Rhodes C, Lipska BK, McMahon FJ.
Neuropsychopharmacology
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IFN-? and TNF-a drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation.
Authors: Zhang F, Mears JR, Shakib L, Beynor JI, Shanaj S, Korsunsky I, Nathan A, Donlin LT, Raychaudhuri S.
Genome Med
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Associations between neighborhood-level factors and opioid-related mortality: A multi-level analysis using death certificate data.
Authors: Flores MW, Lê Cook B, Mullin B, Halperin-Goldstein G, Nathan A, Tenso K, Schuman-Olivier Z.
Addiction
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BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Authors: Pourhaghighi R, Ash PEA, Phanse S, Goebels F, Hu LZM, Chen S, Zhang Y, Wierbowski SD, Boudeau S, Moutaoufik MT, Malty RH, Malolepsza E, Tsafou K, Nathan A, Cromar G, Guo H, Al Abdullatif A, Apicco DJ, Becker LA, Gitler AD, Pulst SM, Youssef A, Hekman R, Havugimana PC, White CA, Blum BC, Ratti A, Bryant CD, Parkinson J, Lage K, Babu M, Yu H, Bader GD, Wolozin B, Emili A.
Cell Syst
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IFN- ? and TNF- a drive a CXCL10 + CCL2 + macrophage phenotype expanded in severe COVID-19 and other diseases with tissue inflammation.
Authors: Zhang F, Mears JR, Shakib L, Beynor JI, Shanaj S, Korsunsky I, Nathan A, Donlin LT, Raychaudhuri S.
bioRxiv
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BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Authors: Pourhaghighi R, Ash PEA, Phanse S, Goebels F, Hu LZM, Chen S, Zhang Y, Wierbowski SD, Boudeau S, Moutaoufik MT, Malty RH, Malolepsza E, Tsafou K, Nathan A, Cromar G, Guo H, Abdullatif AA, Apicco DJ, Becker LA, Gitler AD, Pulst SM, Youssef A, Hekman R, Havugimana PC, White CA, Blum BC, Ratti A, Bryant CD, Parkinson J, Lage K, Babu M, Yu H, Bader GD, Wolozin B, Emili A.
Cell Syst
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Multimodal single-cell approaches shed light on T cell heterogeneity.
Authors: Nathan A, Baglaenko Y, Fonseka CY, Beynor JI, Raychaudhuri S.
Curr Opin Immunol
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Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions.
Authors: Gutierrez-Arcelus M, Teslovich N, Mola AR, Polidoro RB, Nathan A, Kim H, Hannes S, Slowikowski K, Watts GFM, Korsunsky I, Brenner MB, Raychaudhuri S, Brennan PJ.
Nat Commun
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Comprehensive functional genomic resource and integrative model for the human brain.
Authors: Wang D, Liu S, Warrell J, Won H, Shi X, Navarro FCP, Clarke D, Gu M, Emani P, Yang YT, Xu M, Gandal MJ, Lou S, Zhang J, Park JJ, Yan C, Rhie SK, Manakongtreecheep K, Zhou H, Nathan A, Peters M, Mattei E, Fitzgerald D, Brunetti T, Moore J, Jiang Y, Girdhar K, Hoffman GE, Kalayci S, Gümüs ZH, Crawford GE.
Science
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Design of Protein-Peptide Interaction Modules for Assembling Supramolecular Structures in Vivo and in Vitro.
Authors: Speltz EB, Nathan A, Regan L.
ACS Chem Biol
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