Doga Gulhan, PhD

Doga Gulhan is the Principal Investigator of Gulhan Lab at Mass General Hospital (MGH) Cancer Center and a Faculty Member HMS. She received her Bachelor of Science degree from Bilkent University's Physics Department. She completed her Ph.D. in high-energy physics at the Massachusetts Institute of Technology and worked as a Research Fellow at CERN. After transitioning to biomedical informatics, she joined Park Lab at the Department of Biomedical Informatics at HMS as a postdoctoral fellow. She studied mutational processes in cancer using signature analysis techniques. She contributed new algorithms to this emerging field that expanded its clinical applications by enabling signature prediction from targeted gene panels (Gulhan et al Nat Genet. 2019) and robust signature discovery and assignments from whole exome and genome datasets (Jin, Gulhan et al Nat Genet. 2024). Her recent work focuses on understanding the immunogenomic and molecular characteristics of tumors with repair deficiencies. Her research program is dedicated to developing a comprehensive suite of tools for deciphering cancer genomes, aimed at personalized oncology. This includes the creation of statistical and machine-learning methods designed specifically for mutational signature analysis, clinical patient classification and tumor evolution inference.