Kun-Hsing Yu, MD, PhD

Kun-Hsing Yu, MD, PhD

Associate Professor of Biomedical Informatics, Harvard Medical School
Assistant Professor of Pathology, Brigham and Women's Hospital
Instructor in Epidemiology, Harvard T.H. Chan School of Public Health
Yu Lab

Kun-Hsing "Kun" Yu received his PhD in Biomedical Informatics and PhD Minor in Computer Science from Stanford University, and he obtained his MD from National Taiwan University, Taiwan. His research focuses on the integration of quantitative histopathology image patterns with multi-omics (genomics, epigenomics, transcriptomics, and proteomics) profiles to advance cancer research and clinical practice. His team has developed fully-automated algorithms to analyze whole-slide histopathology images at scale, discovered the molecular mechanisms underpinning the microscopic phenotypes of tumor cells, and identified novel cellular morphologies for patient prognosis. His research interests include quantitative pathology, machine learning, and translational bioinformatics.

DBMI Research Areas
DBMI Courses
Current Postdoctoral Fellowship Opportunities
Multi-organ immune-related adverse events from immune checkpoint inhibitors and their downstream implications: a retrospective multicohort study.
Authors: Wan G, Chen W, Khattab S, Roster K, Nguyen N, Yan B, Rajeh A, Seo J, Rashdan H, Zubiri L, Hadfield MJ, Demehri S, Yu KH, Lotter W, Gusev A, LeBoeuf NR, Reynolds KL, Kwatra SG, Semenov YR.
Lancet Oncol
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Mitochondrial dysfunction and immune suppression in BRAF V600E-mutated metastatic melanoma.
Authors: Pinto de Almeida N, Jánosi ÁJ, Hong R, Rajeh A, Nogueira F, Szadai L, Szeitz B, Pla Parada I, Doma V, Woldmar N, Guedes J, Újfaludi Z, Bartha A, Kim Y, Welinder C, Baldetorp B, Kemény LV, Pahi Z, Wan G, Nguyen N, Pankotai T, Gyorffy B, Pawlowski K, Horvatovich P, Szasz AM, Sanchez A, Kuras M, Rodriguez Murillo J, Betancourt L, Domont GB, Semenov YR, Yu KH, Kwon HJ, Németh IB, Fenyo D, Wieslander E, Marko-Varga G, Gil J.
Clin Transl Med
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Cancer type and histology influence cutaneous immunotherapy toxicities: a multi-institutional cohort study.
Authors: Wan G, Khattab S, Leung BW, Zhang S, Nguyen N, Tran M, Lin C, Chang C, Alexander N, Jairath R, Phillipps J, Tang K, Rajeh A, Zubiri L, Chen ST, Demehri S, Yu KH, Gusev A, Kwatra SG, LeBoeuf NR, Reynolds KL, Semenov YR.
Br J Dermatol
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Medical Artificial Intelligence and Human Values.
Authors: Yu KH, Healey E, Leong TY, Kohane IS, Manrai AK.
N Engl J Med
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SpatialCells: automated profiling of tumor microenvironments with spatially resolved multiplexed single-cell data.
Authors: Wan G, Maliga Z, Yan B, Vallius T, Shi Y, Khattab S, Chang C, Nirmal AJ, Yu KH, Liu D, Lian CG, DeSimone MS, Sorger PK, Semenov YR.
Brief Bioinform
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Development and validation of time-to-event models to predict metastatic recurrence of localized cutaneous melanoma.
Authors: Wan G, Leung BW, DeSimone MS, Nguyen N, Rajeh A, Collier MR, Rashdan H, Roster K, Zhou X, Moseley CB, Nirmal AJ, Pelletier RJ, Maliga Z, Marko-Varga G, Németh IB, Tsao H, Asgari MM, Gusev A, Stagner AM, Lian CG, Hurlbert MS, Liu F, Yu KH, Sorger PK, Semenov YR.
J Am Acad Dermatol
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SpatialCells: Automated Profiling of Tumor Microenvironments with Spatially Resolved Multiplexed Single-Cell Data.
Authors: Wan G, Maliga Z, Yan B, Vallius T, Shi Y, Khattab S, Chang C, Nirmal AJ, Yu KH, Liu D, Lian CG, DeSimone MS, Sorger PK, Semenov YR.
bioRxiv
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Mitochondrial and immune response dysregulation in melanoma recurrence.
Authors: Szadai L, Guedes JS, Woldmar N, de Almeida NP, Jánosi ÁJ, Rajeh A, Kovács F, Kriston A, Migh E, Wan G, Nguyen N, Oskolás H, Appelqvist R, Nogueira FC, Domont GB, Yu KH, Semenov ER, Malm J, Rezeli M, Wieslander E, Fenyö D, Kemény L, Horvath P, Németh IB, Marko-Varga G, Gil J.
Clin Transl Med
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Large-scale real-world data analyses of cancer risks among patients with rheumatoid arthritis.
Authors: Wang F, Palmer N, Fox K, Liao KP, Yu KH, Kou SC.
Int J Cancer
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Machine learning for cryosection pathology predicts the 2021 WHO classification of glioma.
Authors: Nasrallah MP, Zhao J, Tsai CC, Meredith D, Marostica E, Ligon KL, Golden JA, Yu KH.
Med
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