Matt Might

Matthew Might, PhD

Senior Lecturer on Biomedical Informatics, Part-time

Matt Might  has been the Director of the Hugh Kaul Precision Medicine Institute at the University of Alabama at Birmingham (UAB) since 2017. At UAB, he is the Hugh Kaul Kaul Endowed Chair of Personalized Medicine, a Professor of Internal Medicine and a Professor of Computer Science. His research at UAB focuses on precision prevention, diagnosis and therapeutics across rare disease, cancer and common/chronic conditions. A principal theme in his research is the use of computer and data science to enhance clinical and academic medicine.

From 2016 to 2018, Might was a Strategist in the Executive Office of the President in The White House. At The White House, he worked primarily on President Obama's Precision Medicine Initiative with both the NIH and the Department of Veterans Affairs.

In 2015, Might joined the faculty of the Department of Biomedical Informatics at Harvard Medical School. At DBMI, his research focuses on rare disease discovery and diagnosis, and on the development of personalized therapeutics for rare disease.

Might is co-founder and Chief Scientific Officer of NGLY1.org, a non-profit dedicated to finding treatments for NGLY1 deficiency, and he was a co-founder and Scientific Advisor to Pairnomix, a start-up which identifies potential patient-specific therapies for rare disorders. Q State Biosciences acquired Pairnomix in October 2018, and Might remains a Scientific Advisor.

Exercise mitigates reductive stress-induced cardiac remodeling in mice.
Authors: Jyothidasan A, Sunny S, Devarajan A, Sayed A, Afortude JK, Dalley B, Nanda V, Pogwizd S, Litovsky SH, Trinity JD, Might M, Rajasekaran NS.
Redox Biol
View full abstract on Pubmed
Data-driven Cluster Analysis Reveals Increased Risk for Severe Insulin-Deficient Diabetes in Black/African Americans.
Authors: Lu B, Li P, Crouse AB, Grimes T, Might M, Ovalle F, Shalev A.
J Clin Endocrinol Metab
View full abstract on Pubmed
Characteristics and determinants of pulmonary long COVID.
Authors: Patton MJ, Benson D, Robison SW, Raval D, Locy ML, Patel K, Grumley S, Levitan EB, Morris P, Might M, Gaggar A, Erdmann N.
JCI Insight
View full abstract on Pubmed
Characteristics and Determinants of Pulmonary Long COVID.
Authors: Patton MJ, Benson D, Robison SW, Dhaval R, Locy ML, Patel K, Grumley S, Levitan EB, Morris P, Might M, Gaggar A, Erdmann N.
medRxiv
View full abstract on Pubmed
Community-acquired bacterial coinfections and COVID-19.
Authors: Patton MJ, Gaggar A, Might M, Erdmann N, Orihuela CJ, Harrod KS.
Physiol Rev
View full abstract on Pubmed
Medical and psychosocial outcomes of state-funded population genomic screening.
Authors: Cannon A, McMillan O, Kelley WV, East KM, Cochran ME, Miskell EL, Moss IP, Garner-Duckworth S, Redden DT, Might M, Barsh GS, Korf BR.
Clin Genet
View full abstract on Pubmed
Circulating SARS-CoV-2+ megakaryocytes are associated with severe viral infection in COVID-19.
Authors: Fortmann SD, Patton MJ, Frey BF, Tipper JL, Reddy SB, Vieira CP, Hanumanthu VS, Sterrett S, Floyd JL, Prasad R, Zucker JD, Crouse AB, Huls F, Chkheidze R, Li P, Erdmann NB, Harrod KS, Gaggar A, Goepfert PA, Grant MB, Might M.
Blood Adv
View full abstract on Pubmed
A Primer in Precision Nephrology: Optimizing Outcomes in Kidney Health and Disease through Data-Driven Medicine.
Authors: Jayaraman P, Crouse A, Nadkarni G, Might M.
Kidney360
View full abstract on Pubmed
Are we prepared to deliver gene-targeted therapies for rare diseases?
Authors: Yu TW, Kingsmore SF, Green RC, MacKenzie T, Wasserstein M, Caggana M, Gold NB, Kennedy A, Kishnani PS, Might M, Brooks PJ, Morris JA, Parisi MA, Urv TK.
Am J Med Genet C Semin Med Genet
View full abstract on Pubmed
COVID-19 bacteremic co-infection is a major risk factor for mortality, ICU admission, and mechanical ventilation.
Authors: Patton MJ, Orihuela CJ, Harrod KS, Bhuiyan MAN, Dominic P, Kevil CG, Fort D, Liu VX, Farhat M, Koff JL, Lal CV, Gaggar A, Richter RP, Erdmann N, Might M, Gaggar A.
Crit Care
View full abstract on Pubmed