Michael Baym received his PhD in Mathematics from MIT and was a postdoctoral fellow at Harvard Medical School in Systems Biology. Baym's research is centered around the problem of antibiotic resistance, at the intersection of experimental, theoretical and computational techniques. His work ranges from understanding the basic mechanisms of evolution to the development of algorithms for computation on massive biological datasets.
DBMI Research Areas
Perfect as the enemy of good: tracing transmissions with low-sensitivity tests to mitigate SARS-CoV-2 outbreaks.
Simplitigs as an efficient and scalable representation of de Bruijn graphs.
Metastable hybridization-based DNA information storage to allow rapid and permanent erasure.
Barcoded microbial system for high-resolution object provenance.
Authors: Qian J, Lu ZX, Mancuso CP, Jhuang HY, Del Carmen Barajas-Ornelas R, Boswell SA, Ramírez-Guadiana FH, Jones V, Sonti A, Sedlack K, Artzi L, Jung G, Arammash M, Pettit ME, Melfi M, Lyon L, Owen SV, Baym M, Khalil AS, Silver PA, Rudner DZ, Springer M.
Science
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Science
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Escape mutations circumvent a tradeoff between resistance to a beta-lactam and resistance to a beta-lactamase inhibitor.
Authors: Russ D, Glaser F, Shaer Tamar E, Yelin I, Baym M, Kelsic ED, Zampaloni C, Haldimann A, Kishony R.
Nat Commun
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Nat Commun
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Rapid inference of antibiotic resistance and susceptibility by genomic neighbour typing.
Authors: Brinda K, Callendrello A, Ma KC, MacFadden DR, Charalampous T, Lee RS, Cowley L, Wadsworth CB, Grad YH, Kucherov G, O'Grady J, Baym M, Hanage WP.
Nat Microbiol
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Nat Microbiol
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The fitness landscape of the African Salmonella Typhimurium ST313 strain D23580 reveals unique properties of the pBT1 plasmid.
Authors: Canals R, Chaudhuri RR, Steiner RE, Owen SV, Quinones-Olvera N, Gordon MA, Baym M, Ibba M, Hinton JCD.
PLoS Pathog
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PLoS Pathog
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Rapid curation of gene disruption collections using Knockout Sudoku.
Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation.
Authors: Riglar DT, Giessen TW, Baym M, Kerns SJ, Niederhuber MJ, Bronson RT, Kotula JW, Gerber GK, Way JC, Silver PA.
Nat Biotechnol
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Nat Biotechnol
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Barcode extension for analysis and reconstruction of structures.
Authors: Myhrvold C, Baym M, Hanikel N, Ong LL, Gootenberg JS, Yin P.
Nat Commun
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Nat Commun
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