Peter Park

Peter Park, PhD

Professor of Biomedical Informatics
Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street, Boston, MA 02115

Dr. Park is a Professor of Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics PhD program. His research group specializes in computational and statistical analysis of large-scale DNA sequencing data to understand genetic and epigenetic mechanisms related to disease processes. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for identifying and interpreting genomic alterations in the human genome, especially those from cancer patients. His group has made major contributions to many consortium projects such as The Cancer Genome Atlas (TCGA), Encyclopedia of DNA Elements (ENCODE), and Brain Somatic Mosaicism Network, and 4D Nucleome, and Somatic Mosaicism across Human Tissues (SMaHT). His work has been funded by the National Institutes of Health, Cancer Research UK Grand Challenges, The Mark Foundation for Cancer Research, Simons Foundation, Chan Zucherberg Initiative, Blavatnik Therapeutics Challenge, the HMS Quadrangle Fund for Advancing and Seeding Translational Research (Q-FASTR), and others.


DBMI Research Areas
DBMI Courses
Robust optimization in intensity-modulated proton therapy to account for anatomy changes in lung cancer patients.
Authors: Li H, Zhang X, Park P, Liu W, Chang J, Liao Z, Frank S, Li Y, Poenisch F, Mohan R, Gillin M, Zhu R.
Radiother Oncol
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Identification of rare germline copy number variations over-represented in five human cancer types.
Authors: Park RW, Kim TM, Kasif S, Park PJ.
Mol Cancer
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Cell lineage analysis in human brain using endogenous retroelements.
Authors: Evrony GD, Lee E, Mehta BK, Benjamini Y, Johnson RM, Cai X, Yang L, Haseley P, Lehmann HS, Park PJ, Walsh CA.
Neuron
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Correspondence of Drosophila polycomb group proteins with broad H3K27me3 silent domains.
Authors: Jung YL, Kang H, Park PJ, Kuroda MI.
Fly (Austin)
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p53 prevents neurodegeneration by regulating synaptic genes.
Authors: Merlo P, Frost B, Peng S, Yang YJ, Park PJ, Feany M.
Proc Natl Acad Sci U S A
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Dosimetric benefits of robust treatment planning for intensity modulated proton therapy for base-of-skull cancers.
Authors: Liu W, Mohan R, Park P, Liu Z, Li H, Li X, Li Y, Wu R, Sahoo N, Dong L, Zhu XR, Grosshans DR.
Pract Radiat Oncol
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lncRNA directs cooperative epigenetic regulation downstream of chemokine signals.
Authors: Xing Z, Lin A, Li C, Liang K, Wang S, Liu Y, Park PK, Qin L, Wei Y, Hawke DH, Hung MC, Lin C, Yang L.
Cell
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A genome-wide view of microsatellite instability: old stories of cancer mutations revisited with new sequencing technologies.
Authors: Kim TM, Park PJ.
Cancer Res
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Characterization of HPV and host genome interactions in primary head and neck cancers.
Authors: Parfenov M, Pedamallu CS, Gehlenborg N, Freeman SS, Danilova L, Bristow CA, Lee S, Hadjipanayis AG, Ivanova EV, Wilkerson MD, Protopopov A, Yang L, Seth S, Song X, Tang J, Ren X, Zhang J, Pantazi A, Santoso N, Xu AW, Mahadeshwar H, Wheeler DA, Haddad RI, Jung J, Ojesina AI, Issaeva N, Yarbrough WG, Hayes DN, Grandis JR, El-Naggar AK, Meyerson M, Park PJ, Chin L, Seidman JG, Hammerman PS, Kucherlapati R.
Proc Natl Acad Sci U S A
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Evaluation of the systematic error in using 3D dose calculation in scanning beam proton therapy for lung cancer.
Authors: Li H, Liu W, Park P, Matney J, Liao Z, Chang J, Zhang X, Li Y, Zhu RX.
J Appl Clin Med Phys
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