Peter Park

Peter Park, PhD

Professor of Biomedical Informatics
Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street, Boston, MA 02115

Dr. Park is a Professor of Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics PhD program. His research group specializes in computational and statistical analysis of large-scale DNA sequencing data to understand genetic and epigenetic mechanisms related to disease processes. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for identifying and interpreting genomic alterations in the human genome, especially those from cancer patients. His group has made major contributions to many consortium projects such as The Cancer Genome Atlas (TCGA), Encyclopedia of DNA Elements (ENCODE), and Brain Somatic Mosaicism Network, and 4D Nucleome, and Somatic Mosaicism across Human Tissues (SMaHT). His work has been funded by the National Institutes of Health, Cancer Research UK Grand Challenges, The Mark Foundation for Cancer Research, Simons Foundation, Chan Zucherberg Initiative, Blavatnik Therapeutics Challenge, the HMS Quadrangle Fund for Advancing and Seeding Translational Research (Q-FASTR), and others.


DBMI Research Areas
DBMI Courses
High-resolution ChIP-chip analysis reveals that the Drosophila MSL complex selectively identifies active genes on the male X chromosome.
Authors: Alekseyenko AA, Larschan E, Lai WR, Park PJ, Kuroda MI.
Genes Dev
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MSL complex associates with clusters of actively transcribed genes along the Drosophila male X chromosome.
Authors: Larschan E, Alekseyenko AA, Lai WR, Park PJ, Kuroda MI.
Cold Spring Harb Symp Quant Biol
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Global regulation of X chromosomal genes by the MSL complex in Drosophila melanogaster.
Authors: Hamada FN, Park PJ, Gordadze PR, Kuroda MI.
Genes Dev
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Comparative analysis of algorithms for identifying amplifications and deletions in array CGH data.
Authors: Lai WR, Johnson MD, Kucherlapati R, Park PJ.
Bioinformatics
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Discovering statistically significant pathways in expression profiling studies.
Authors: Tian L, Greenberg SA, Kong SW, Altschuler J, Kohane IS, Park PJ.
Proc Natl Acad Sci U S A
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Interferon-alpha/beta-mediated innate immune mechanisms in dermatomyositis.
Authors: Greenberg SA, Pinkus JL, Pinkus GS, Burleson T, Sanoudou D, Tawil R, Barohn RJ, Saperstein DS, Briemberg HR, Ericsson M, Park P, Amato AA.
Ann Neurol
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CrossChip: a system supporting comparative analysis of different generations of Affymetrix arrays.
Authors: Kong SW, Hwang KB, Kim RD, Zhang BT, Greenberg SA, Kohane IS, Park PJ.
Bioinformatics
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Combining gene expression data from different generations of oligonucleotide arrays.
Authors: Hwang KB, Kong SW, Greenberg SA, Park PJ.
BMC Bioinformatics
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Current issues for DNA microarrays: platform comparison, double linear amplification, and universal RNA reference.
Authors: Park PJ, Cao YA, Lee SY, Kim JW, Chang MS, Hart R, Choi S.
J Biotechnol
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Improving identification of differentially expressed genes in microarray studies using information from public databases.
Authors: Kim RD, Park PJ.
Genome Biol
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