Peter Park

Peter Park, PhD

Professor of Biomedical Informatics
Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street, Boston, MA 02115

Dr. Park is a Professor of Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics PhD program. His research group specializes in computational and statistical analysis of large-scale DNA sequencing data to understand genetic and epigenetic mechanisms related to disease processes. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for identifying and interpreting genomic alterations in the human genome, especially those from cancer patients. His group has made major contributions to many consortium projects such as The Cancer Genome Atlas (TCGA), Encyclopedia of DNA Elements (ENCODE), and Brain Somatic Mosaicism Network, and 4D Nucleome, and Somatic Mosaicism across Human Tissues (SMaHT). His work has been funded by the National Institutes of Health, Cancer Research UK Grand Challenges, The Mark Foundation for Cancer Research, Simons Foundation, Chan Zucherberg Initiative, Blavatnik Therapeutics Challenge, the HMS Quadrangle Fund for Advancing and Seeding Translational Research (Q-FASTR), and others.


DBMI Research Areas
DBMI Courses
Landmarks of human embryonic development inscribed in somatic mutations.
Authors: Bizzotto S, Dou Y, Ganz J, Doan RN, Kwon M, Bohrson CL, Kim SN, Bae T, Abyzov A, Park PJ, Walsh CA.
Science
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Deletions in CWH43 cause idiopathic normal pressure hydrocephalus.
Authors: Yang HW, Lee S, Yang D, Dai H, Zhang Y, Han L, Zhao S, Zhang S, Ma Y, Johnson MF, Rattray AK, Johnson TA, Wang G, Zheng S, Carroll RS, Park PJ, Johnson MD.
EMBO Mol Med
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The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing.
Authors: Rodin RE, Dou Y, Kwon M, Sherman MA, D'Gama AM, Doan RN, Rento LM, Girskis KM, Bohrson CL, Kim SN, Nadig A, Luquette LJ, Gulhan DC, Park PJ, Walsh CA.
Nat Neurosci
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Large mosaic copy number variations confer autism risk.
Authors: Sherman MA, Rodin RE, Genovese G, Dias C, Barton AR, Mukamel RE, Berger B, Park PJ, Walsh CA, Loh PR.
Nat Neurosci
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BamSnap: a lightweight viewer for sequencing reads in BAM files.
Authors: Kwon M, Lee S, Berselli M, Chu C, Park PJ.
Bioinformatics
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The conserved elongation factor Spn1 is required for normal transcription, histone modifications, and splicing in Saccharomyces cerevisiae.
Authors: Reim NI, Chuang J, Jain D, Alver BH, Park PJ, Winston F.
Nucleic Acids Res
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Identification and Genotyping of Transposable Element Insertions From Genome Sequencing Data.
Authors: Chu C, Zhao B, Park PJ, Lee EA.
Curr Protoc Hum Genet
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A user guide for the online exploration and visualization of PCAWG data.
Authors: Goldman MJ, Zhang J, Fonseca NA, Cortés-Ciriano I, Xiang Q, Craft B, Piñeiro-Yáñez E, O'Connor BD, Bazant W, Barrera E, Muñoz-Pomer A, Petryszak R, Füllgrabe A, Al-Shahrour F, Keays M, Haussler D, Weinstein JN, Huber W, Valencia A, Park PJ, Papatheodorou I, Zhu J, Ferretti V, Vazquez M.
Nat Commun
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Dysregulation of cancer genes by recurrent intergenic fusions.
Authors: Yun JW, Yang L, Park HY, Lee CW, Cha H, Shin HT, Noh KW, Choi YL, Park WY, Park PJ.
Genome Biol
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Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injury.
Authors: Ettou S, Jung YL, Miyoshi T, Jain D, Hiratsuka K, Schumacher V, Taglienti ME, Morizane R, Park PJ, Kreidberg JA.
Sci Adv
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