Shamil Sunyaev

Shamil Sunyaev, PhD

Professor of Biomedical Informatics, Harvard Medical School
Professor of Medicine, Brigham and Women’s Hospital

10 Shattuck Street, Room 311A, Boston, MA 02115

Shamil Sunyaev is a computational genomicist and geneticist. Research in his lab encompasses many aspects of population genetic variation including the origin of mutations, the effect of allelic variants on molecular function, population and evolutionary genetics, and genetics of human complex and Mendelian traits. He developed several computational and statistical methods widely adopted by the community. Sunyaev obtained a PhD in molecular biophysics from the Moscow Institute of Physics and Technology and completed his postdoctoral training in bioinformatics at the European Molecular Biology Laboratory (EMBL). He is an Institute Member at Broad Institute of MIT and Harvard. He also co-organizes the Boston Evolutionary Genomics Supergroup.


DBMI Research Areas
DBMI Courses
AnFiSA: An open-source computational platform for the analysis of sequencing data for rare genetic disease.
Authors: Bouzinier MA, Etin D, Trifonov SI, Evdokimova VN, Ulitin V, Shen J, Kokorev A, Ghazani AA, Chekaluk Y, Albertyn Z, Giersch A, Morton CC, Abraamyan F, Bendapudi PK, Sunyaev S, Krier JB.
J Biomed Inform
View full abstract on Pubmed
A cross-disorder dosage sensitivity map of the human genome.
Authors: Collins RL, Glessner JT, Porcu E, Lepamets M, Brandon R, Lauricella C, Han L, Morley T, Niestroj LM, Ulirsch J, Everett S, Howrigan DP, Boone PM, Fu J, Karczewski KJ, Kellaris G, Lowther C, Lucente D, Mohajeri K, Nõukas M, Nuttle X, Samocha KE, Trinh M, Ullah F, Võsa U, Hurles ME, Aradhya S, Davis EE, Finucane H, Gusella JF, Janze A, Katsanis N, Matyakhina L, Neale BM, Sanders D, Warren S, Hodge JC, Lal D, Ruderfer DM, Meck J, Mägi R, Esko T, Reymond A, Kutalik Z, Hakonarson H, Sunyaev S, Brand H, Talkowski ME.
Cell
View full abstract on Pubmed
The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.
Authors: Hallacli E, Kayatekin C, Nazeen S, Wang XH, Sheinkopf Z, Sathyakumar S, Sarkar S, Jiang X, Dong X, Di Maio R, Wang W, Keeney MT, Felsky D, Sandoe J, Vahdatshoar A, Udeshi ND, Mani DR, Carr SA, Lindquist S, De Jager PL, Bartel DP, Myers CL, Greenamyre JT, Feany MB, Sunyaev SR, Chung CY, Khurana V.
Cell
View full abstract on Pubmed
Genome-wide analysis of somatic noncoding mutation patterns in cancer.
Authors: Dietlein F, Wang AB, Fagre C, Tang A, Besselink NJM, Cuppen E, Li C, Sunyaev SR, Neal JT, Van Allen EM.
Science
View full abstract on Pubmed
StrVCTVRE: A supervised learning method to predict the pathogenicity of human genome structural variants.
Authors: Sharo AG, Hu Z, Sunyaev SR, Brenner SE.
Am J Hum Genet
View full abstract on Pubmed
Overcoming constraints on the detection of recessive selection in human genes from population frequency data.
Authors: Balick DJ, Jordan DM, Sunyaev S, Do R.
Am J Hum Genet
View full abstract on Pubmed
Author Correction: The origin of human mutation in light of genomic data.
Authors: Seplyarskiy VB, Sunyaev S.
Nat Rev Genet
View full abstract on Pubmed
The origin of human mutation in light of genomic data.
Authors: Seplyarskiy VB, Sunyaev S.
Nat Rev Genet
View full abstract on Pubmed
Population sequencing data reveal a compendium of mutational processes in the human germ line.
Authors: Seplyarskiy VB, Soldatov RA, Koch E, McGinty RJ, Goldmann JM, Hernandez RD, Barnes K, Correa A, Burchard EG, Ellinor PT, McGarvey ST, Mitchell BD, Vasan RS, Redline S, Silverman E, Weiss ST, Arnett DK, Blangero J, Boerwinkle E, He J, Montgomery C, Rao DC, Rotter JI, Taylor KD, Brody JA, Chen YI, de Las Fuentes L, Hwu CM, Rich SS, Manichaikul AW, Mychaleckyj JC, Palmer ND, Smith JA, Kardia SLR, Peyser PA, Bielak LF, O'Connor TD, Emery LS, Gilissen C, Wong WSW, Kharchenko PV, Sunyaev S.
Science
View full abstract on Pubmed
Replicate sequencing libraries are important for quantification of allelic imbalance.
Authors: Mendelevich A, Vinogradova S, Gupta S, Mironov AA, Sunyaev SR, Gimelbrant AA.
Nat Commun
View full abstract on Pubmed