Shamil Sunyaev

Shamil Sunyaev, PhD

Professor of Biomedical Informatics, Harvard Medical School
Professor of Medicine, Brigham and Women’s Hospital

10 Shattuck Street, Room 311A, Boston, MA 02115

Shamil Sunyaev is a computational genomicist and geneticist. Research in his lab encompasses many aspects of population genetic variation including the origin of mutations, the effect of allelic variants on molecular function, population and evolutionary genetics, and genetics of human complex and Mendelian traits. He developed several computational and statistical methods widely adopted by the community. Sunyaev obtained a PhD in molecular biophysics from the Moscow Institute of Physics and Technology and completed his postdoctoral training in bioinformatics at the European Molecular Biology Laboratory (EMBL). He is an Institute Member at Broad Institute of MIT and Harvard. He also co-organizes the Boston Evolutionary Genomics Supergroup.


DBMI Research Areas
DBMI Courses
Power of deep, all-exon resequencing for discovery of human trait genes.
Authors: Kryukov GV, Shpunt A, Stamatoyannopoulos JA, Sunyaev SR.
Proc Natl Acad Sci U S A
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Adaptive mutations in the JC virus protein capsid are associated with progressive multifocal leukoencephalopathy (PML).
Authors: Sunyaev SR, Lugovskoy A, Simon K, Gorelik L.
PLoS Genet
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SNP2RFLP: a computational tool to facilitate genetic mapping using benchtop analysis of SNPs.
Authors: Beckstead WA, Bjork BC, Stottmann RW, Sunyaev S, Beier DR.
Mamm Genome
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Erratum.
Authors: Schmidt S, Gerasimova A, Kondrashov FA, Adzhubei IA, Kondrashov AS, Sunyaev S.
PLoS Genet
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Hypermutable non-synonymous sites are under stronger negative selection.
Authors: Schmidt S, Gerasimova A, Kondrashov FA, Adzhubei IA, Adzuhbei IA, Kondrashov AS, Sunyaev S.
PLoS Genet
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Protein identification pipeline for the homology-driven proteomics.
Authors: Junqueira M, Spirin V, Balbuena TS, Thomas H, Adzhubei I, Sunyaev S, Shevchenko A.
J Proteomics
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Separating the wheat from the chaff: unbiased filtering of background tandem mass spectra improves protein identification.
Authors: Junqueira M, Spirin V, Santana Balbuena T, Waridel P, Surendranath V, Kryukov G, Adzhubei I, Thomas H, Sunyaev S, Shevchenko A.
J Proteome Res
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Assessing the evolutionary impact of amino acid mutations in the human genome.
Authors: Boyko AR, Williamson SH, Indap AR, Degenhardt JD, Hernandez RD, Lohmueller KE, Adams MD, Schmidt S, Sninsky JJ, Sunyaev SR, White TJ, Nielsen R, Clark AG, Bustamante CD.
PLoS Genet
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Proportionally more deleterious genetic variation in European than in African populations.
Authors: Lohmueller KE, Indap AR, Schmidt S, Boyko AR, Hernandez RD, Hubisz MJ, Sninsky JJ, White TJ, Sunyaev SR, Nielsen R, Clark AG, Bustamante CD.
Nature
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Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms.
Authors: Gorlov IP, Gorlova OY, Sunyaev SR, Spitz MR, Amos CI.
Am J Hum Genet
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