Shamil Sunyaev

Shamil Sunyaev, PhD

Professor of Biomedical Informatics, Harvard Medical School
Professor of Medicine, Brigham and Women’s Hospital

10 Shattuck Street, Room 311A, Boston, MA 02115

Shamil Sunyaev is a computational genomicist and geneticist. Research in his lab encompasses many aspects of population genetic variation including the origin of mutations, the effect of allelic variants on molecular function, population and evolutionary genetics, and genetics of human complex and Mendelian traits. He developed several computational and statistical methods widely adopted by the community. Sunyaev obtained a PhD in molecular biophysics from the Moscow Institute of Physics and Technology and completed his postdoctoral training in bioinformatics at the European Molecular Biology Laboratory (EMBL). He is an Institute Member at Broad Institute of MIT and Harvard. He also co-organizes the Boston Evolutionary Genomics Supergroup.


DBMI Research Areas
DBMI Courses
From analysis of protein structural alignments toward a novel approach to align protein sequences.
Authors: Sunyaev SR, Bogopolsky GA, Oleynikova NV, Vlasov PK, Finkelstein AV, Roytberg MA.
Proteins
View full abstract on Pubmed
Impact of selection, mutation rate and genetic drift on human genetic variation.
Authors: Sunyaev S, Kondrashov FA, Bork P, Ramensky V.
Hum Mol Genet
View full abstract on Pubmed
Metabolites: a helping hand for pathway evolution?
Authors: Schmidt S, Sunyaev S, Bork P, Dandekar T.
Trends Biochem Sci
View full abstract on Pubmed
MultiTag: multiple error-tolerant sequence tag search for the sequence-similarity identification of proteins by mass spectrometry.
Authors: Sunyaev S, Liska AJ, Golod A, Shevchenko A, Shevchenko A.
Anal Chem
View full abstract on Pubmed
A model for statistical significance of local similarities in structure.
Authors: Stark A, Sunyaev S, Russell RB.
J Mol Biol
View full abstract on Pubmed
Increase of functional diversity by alternative splicing.
Authors: Kriventseva EV, Koch I, Apweiler R, Vingron M, Bork P, Gelfand MS, Sunyaev S.
Trends Genet
View full abstract on Pubmed
Nanoelectrospray tandem mass spectrometry and sequence similarity searching for identification of proteins from organisms with unknown genomes.
Authors: Shevchenko A, Sunyaev S, Liska A, Bork P, Shevchenko A.
Methods Mol Biol
View full abstract on Pubmed
Dobzhansky-Muller incompatibilities in protein evolution.
Authors: Kondrashov AS, Sunyaev S, Kondrashov FA.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Human non-synonymous SNPs: server and survey.
Authors: Ramensky V, Bork P, Sunyaev S.
Nucleic Acids Res
View full abstract on Pubmed
Charting the proteomes of organisms with unsequenced genomes by MALDI-quadrupole time-of-flight mass spectrometry and BLAST homology searching.
Authors: Shevchenko A, Sunyaev S, Loboda A, Shevchenko A, Bork P, Ens W, Standing KG.
Anal Chem
View full abstract on Pubmed