Shawn Norman Murphy, M.D., Ph.D.
Shawn Murphy, MD, PhD
Professor of Neurology at MGH
Professor of Biomedical Informatics, Harvard Medical School (Secondary)

Shawn Murphy currently serves as the Director of Research Computing and Informatics at Partners Healthcare and Associate Director for the Laboratory of Computer Science at the Massachusetts General Hospital where he developed the Research Patient Data Registry (RPDR) for Partners Healthcare. This application, which serves over 5,000 investigators performing research using the hospital medical record, served as the test bed for his work with Zak Kohane in developing the open source Informatics for Integrating Biology and the Bedside (i2b2) software platform now operating at over 120 hospitals worldwide. Murphy’s contribution as chief architect of the i2b2 platform has served to strengthen the understanding of the metabolic and genetic underpinnings of complex diseases by developing an informatics framework to integrate data for clinical research from electronic health records. He is co-PI with Zak Kohane of the next generation platform, Patient-centered Information Commons BD2K Center of Excellence, which will integrate data sourced not only from the EHR, but also social medial, “omic” inputs, radiology reports, and environmental feeds and co-Investgiator on the PCORI-supported Accessible Research Commons for Health (ARCH) program, both of which are based at DBMI.

Decreased Total Iron Binding Capacity May Correlate with Ruptured Intracranial Aneurysms.
Authors: Can A, Lai PMR, Castro VM, Yu S, Dligach D, Finan S, Gainer V, Shadick NA, Savova G, Murphy S, Cai T, Weiss ST, Du R.
Sci Rep
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A federated EHR network data completeness tracking system.
Authors: Estiri H, Klann JG, Weiler SR, Alema-Mensah E, Joseph Applegate R, Lozinski G, Patibandla N, Wei K, Adams WG, Natter MD, Ofili EO, Ostasiewski B, Quarshie A, Rosenthal GE, Bernstam EV, Mandl KD, Murphy SN.
J Am Med Inform Assoc
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Semi-supervised encoding for outlier detection in clinical observation data.
Authors: Estiri H, Murphy SN.
Comput Methods Programs Biomed
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Probabilistic record linkage of de-identified research datasets with discrepancies using diagnosis codes.
Authors: Hejblum BP, Weber GM, Liao KP, Palmer NP, Churchill S, Shadick NA, Szolovits P, Murphy SN, Kohane IS, Cai T.
Sci Data
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Data model harmonization for the All Of Us Research Program: Transforming i2b2 data into the OMOP common data model.
Authors: Klann JG, Joss MAH, Embree K, Murphy SN.
PLoS One
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Field of View Normalization in Multi-Site Brain MRI.
Authors: Ou Y, Zöllei L, Da X, Retzepi K, Murphy SN, Gerstner ER, Rosen BR, Grant PE, Kalpathy-Cramer J, Gollub RL.
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Empowering genomic medicine by establishing critical sequencing result data flows: the eMERGE example.
Authors: Aronson S, Babb L, Ames D, Gibbs RA, Venner E, Connelly JJ, Marsolo K, Weng C, Williams MS, Hartzler AL, Liang WH, Ralston JD, Devine EB, Murphy S, Chute CG, Caraballo PJ, Kullo IJ, Freimuth RR, Rasmussen LV, Wehbe FH, Peterson JF, Robinson JR, Wiley K, Overby Taylor C.
J Am Med Inform Assoc
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Web services for data warehouses: OMOP and PCORnet on i2b2.
Authors: Klann JG, Phillips LC, Herrick C, Joss MAH, Wagholikar KB, Murphy SN.
J Am Med Inform Assoc
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Accrual to Clinical Trials (ACT): A Clinical and Translational Science Award Consortium Network.
Authors: Visweswaran S, Becich MJ, D'Itri VS, Sendro ER, MacFadden D, Anderson NR, Allen KA, Ranganathan D, Murphy SN, Morrato EH, Pincus HA, Toto R, Firestein GS, Nadler LM, Reis SE.
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Extraction of Ejection Fraction from Echocardiography Notes for Constructing a Cohort of Patients having Heart Failure with reduced Ejection Fraction (HFrEF).
Authors: Wagholikar KB, Fischer CM, Goodson A, Herrick CD, Rees M, Toscano E, MacRae CA, Scirica BM, Desai AS, Murphy SN.
J Med Syst
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