Shawn Norman Murphy, M.D., Ph.D.

Shawn Murphy, MD, PhD

Professor of Neurology at MGH
Associate Professor of Biomedical Informatics, Harvard Medical School (Secondary)

Shawn Murphy currently serves as the Director of Research Computing and Informatics at Partners Healthcare and Associate Director for the Laboratory of Computer Science at the Massachusetts General Hospital where he developed the Research Patient Data Registry (RPDR) for Partners Healthcare. This application, which serves over 5,000 investigators performing research using the hospital medical record, served as the test bed for his work with Zak Kohane in developing the open source Informatics for Integrating Biology and the Bedside (i2b2) software platform now operating at over 120 hospitals worldwide. Murphy’s contribution as chief architect of the i2b2 platform has served to strengthen the understanding of the metabolic and genetic underpinnings of complex diseases by developing an informatics framework to integrate data for clinical research from electronic health records.

Distribution of agitation and related symptoms among hospitalized patients using a scalable natural language processing method.
Authors: Hart KL, Pellegrini AM, Forester BP, Berretta S, Murphy SN, Perlis RH, McCoy TH.
Gen Hosp Psychiatry
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Geometric variations associated with posterior communicating artery aneurysms.
Authors: Zhang J, Can A, Lai PMR, Mukundan S, Castro VM, Dligach D, Finan S, Gainer V, Shadick N, Savova G, Murphy SN, Cai T, Weiss ST, Du R.
J Neurointerv Surg
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Clinical knowledge extraction via sparse embedding regression (KESER) with multi-center large scale electronic health record data.
Authors: Hong C, Rush E, Liu M, Zhou D, Sun J, Sonabend A, Castro VM, Schubert P, Panickan VA, Cai T, Costa L, He Z, Link N, Hauser R, Gaziano JM, Murphy SN, Ostrouchov G, Ho YL, Begoli E, Lu J, Cho K, Liao KP, Cai T.
NPJ Digit Med
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International Changes in COVID-19 Clinical Trajectories Across 315 Hospitals and 6 Countries: Retrospective Cohort Study.
Authors: Weber GM, Zhang HG, L'Yi S, Bonzel CL, Hong C, Avillach P, Gutiérrez-Sacristán A, Palmer NP, Tan ALM, Wang X, Yuan W, Gehlenborg N, Alloni A, Amendola DF, Bellasi A, Bellazzi R, Beraghi M, Bucalo M, Chiovato L, Cho K, Dagliati A, Estiri H, Follett RW, García Barrio N, Hanauer DA, Henderson DW, Ho YL, Holmes JH, Hutch MR, Kavuluru R, Kirchoff K, Klann JG, Krishnamurthy AK, Le TT, Liu M, Loh NHW, Lozano-Zahonero S, Luo Y, Maidlow S, Makoudjou A, Malovini A, Martins MR, Moal B, Morris M, Mowery DL, Murphy SN, Neuraz A, Ngiam KY, Okoshi MP, Omenn GS, Patel LP, Pedrera Jiménez M, Prudente RA, Samayamuthu MJ, Sanz Vidorreta FJ, Schriver ER, Schubert P, Serrano Balazote P, Tan BW, Tanni SE, Tibollo V, Visweswaran S, Wagholikar KB, Xia Z, Zöller D, Kohane IS, Cai T, South AM, Brat GA.
J Med Internet Res
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An independently validated, portable algorithm for the rapid identification of COPD patients using electronic health records.
Authors: Chu SH, Wan ES, Cho MH, Goryachev S, Gainer V, Linneman J, Scotty EJ, Hebbring SJ, Murphy S, Lasky-Su J, Weiss ST, Smoller JW, Karlson E.
Sci Rep
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ATLAS: an automated association test using probabilistically linked health records with application to genetic studies.
Authors: Zhang HG, Hejblum BP, Weber GM, Palmer NP, Churchill SE, Szolovits P, Murphy SN, Liao KP, Kohane IS, Cai T.
J Am Med Inform Assoc
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Evolving phenotypes of non-hospitalized patients that indicate long COVID.
Authors: Estiri H, Strasser ZH, Brat GA, Semenov YR, Patel CJ, Murphy SN.
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Longitudinal Data Discontinuity in Electronic Health Records and Consequences for Medication Effectiveness Studies.
Authors: Joshua Lin K, Jin Y, Gagne J, Glynn RJ, Murphy SN, Tong A, Schneeweiss S.
Clin Pharmacol Ther
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Multi-channel attention-fusion neural network for brain age estimation: Accuracy, generality, and interpretation with 16,705 healthy MRIs across lifespan.
Authors: He S, Pereira D, David Perez J, Gollub RL, Murphy SN, Prabhu S, Pienaar R, Robertson RL, Ellen Grant P, Ou Y.
Med Image Anal
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Quantitative disease risk scores from EHR with applications to clinical risk stratification and genetic studies.
Authors: Xu D, Wang C, Khan A, Shang N, He Z, Gordon A, Kullo IJ, Murphy S, Ni Y, Wei WQ, Gharavi A, Kiryluk K, Weng C, Ionita-Laza I.
NPJ Digit Med
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