Shawn Norman Murphy, M.D., Ph.D.

Shawn Murphy, MD, PhD

Professor of Neurology at MGH
Associate Professor of Biomedical Informatics, Harvard Medical School (Secondary)

6177247980

Shawn Murphy currently serves as the Director of Research Computing and Informatics at Partners Healthcare and Associate Director for the Laboratory of Computer Science at the Massachusetts General Hospital where he developed the Research Patient Data Registry (RPDR) for Partners Healthcare. This application, which serves over 5,000 investigators performing research using the hospital medical record, served as the test bed for his work with Zak Kohane in developing the open source Informatics for Integrating Biology and the Bedside (i2b2) software platform now operating at over 120 hospitals worldwide. Murphy’s contribution as chief architect of the i2b2 platform has served to strengthen the understanding of the metabolic and genetic underpinnings of complex diseases by developing an informatics framework to integrate data for clinical research from electronic health records.

Current state of information technologies for the clinical research enterprise across academic medical centers.
Authors: Murphy SN, Dubey A, Embi PJ, Harris PA, Richter BG, Turisco F, Weber GM, Tcheng JE, Keogh D.
Clin Transl Sci
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Predictors of severe outcomes associated with Clostridium difficile infection in patients with inflammatory bowel disease.
Authors: Ananthakrishnan AN, Guzman-Perez R, Gainer V, Cai T, Churchill S, Kohane I, Plenge RM, Murphy S.
Aliment Pharmacol Ther
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Apps to display patient data, making SMART available in the i2b2 platform.
Authors: Wattanasin N, Porter A, Ubaha S, Mendis M, Phillips L, Mandel J, Ramoni R, Mandl K, Kohane I, Murphy SN.
AMIA Annu Symp Proc
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Incident user cohort study of risk for gastrointestinal bleed and stroke in individuals with major depressive disorder treated with antidepressants.
Authors: Castro VM, Gallagher PJ, Clements CC, Murphy SN, Gainer VS, Fava M, Weilburg JB, Churchill SE, Kohane IS, Iosifescu DV, Smoller JW, Perlis RH.
BMJ Open
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Using electronic medical records to enable large-scale studies in psychiatry: treatment resistant depression as a model.
Authors: Perlis RH, Iosifescu DV, Castro VM, Murphy SN, Gainer VS, Minnier J, Cai T, Goryachev S, Zeng Q, Gallagher PJ, Fava M, Weilburg JB, Churchill SE, Kohane IS, Smoller JW.
Psychol Med
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Clinical Bioinformatics: challenges and opportunities.
Authors: Bellazzi R, Masseroli M, Murphy S, Shabo A, Romano P.
BMC Bioinformatics
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The co-morbidity burden of children and young adults with autism spectrum disorders.
Authors: Kohane IS, McMurry A, Weber G, MacFadden D, Rappaport L, Kunkel L, Bickel J, Wattanasin N, Spence S, Murphy S, Churchill S.
PLoS One
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Strategies for maintaining patient privacy in i2b2.
Authors: Murphy SN, Gainer V, Mendis M, Churchill S, Kohane I.
J Am Med Inform Assoc
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Detecting drug interactions from adverse-event reports: interaction between paroxetine and pravastatin increases blood glucose levels.
Authors: Tatonetti NP, Denny JC, Murphy SN, Fernald GH, Krishnan G, Castro V, Yue P, Tsao PS, Tsau PS, Kohane I, Roden DM, Altman RB.
Clin Pharmacol Ther
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Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records.
Authors: Kurreeman F, Liao K, Chibnik L, Hickey B, Stahl E, Gainer V, Li G, Bry L, Mahan S, Ardlie K, Thomson B, Szolovits P, Churchill S, Murphy SN, Cai T, Raychaudhuri S, Kohane I, Karlson E, Plenge RM.
Am J Hum Genet
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