Shawn Murphy

Shawn Murphy, MD, PhD

Professor of Neurology at MGH

Associate Professor of Biomedical Informatics, Harvard Medical School (Secondary)

6177247980

Research
Publications

Shawn Murphy currently serves as the Director of Research Computing and Informatics at Partners Healthcare and Associate Director for the Laboratory of Computer Science at the Massachusetts General Hospital where he developed the Research Patient Data Registry (RPDR) for Partners Healthcare. This application, which serves over 5,000 investigators performing research using the hospital medical record, served as the test bed for his work with Zak Kohane in developing the open source Informatics for Integrating Biology and the Bedside (i2b2) software platform now operating at over 120 hospitals worldwide. Murphy’s contribution as chief architect of the i2b2 platform has served to strengthen the understanding of the metabolic and genetic underpinnings of complex diseases by developing an informatics framework to integrate data for clinical research from electronic health records.

Multiview Incomplete Knowledge Graph Integration with application to cross-institutional EHR data harmonization.

Authors: Zhou D, Gan Z, Shi X, Patwari A, Rush E, Bonzel CL, Panickan VA, Hong C, Ho YL, Cai T, Costa L, Li X, Castro VM, Murphy SN, Brat G, Weber G, Avillach P, Gaziano JM, Cho K, Liao KP, Lu J, Cai T.
J Biomed Inform 2022-09-01
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Natural Language Processing to Improve Prediction of Incident Atrial Fibrillation Using Electronic Health Records.

Authors: Ashburner JM, Chang Y, Wang X, Khurshid S, Anderson CD, Dahal K, Weisenfeld D, Cai T, Liao KP, Wagholikar KB, Murphy SN, Atlas SJ, Lubitz SA, Singer DE.
J Am Heart Assoc 2022-08-02
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An objective framework for evaluating unrecognized bias in medical AI models predicting COVID-19 outcomes.

Authors: Estiri H, Strasser ZH, Rashidian S, Klann JG, Wagholikar KB, McCoy TH, Murphy SN.
J Am Med Inform Assoc 2022-07-12
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International electronic health record-derived post-acute sequelae profiles of COVID-19 patients.

Authors: Zhang HG, Dagliati A, Shakeri Hossein Abad Z, Xiong X, Bonzel CL, Xia Z, Tan BWQ, Avillach P, Brat GA, Hong C, Morris M, Visweswaran S, Patel LP, Gutiérrez-Sacristán A, Hanauer DA, Holmes JH, Samayamuthu MJ, Bourgeois FT, L'Yi S, Maidlow SE, Moal B, Murphy SN, Strasser ZH, Neuraz A, Ngiam KY, Loh NHW, Omenn GS, Prunotto A, Dalvin LA, Klann JG, Schubert P, Vidorreta FJS, Benoit V, Verdy G, Kavuluru R, Estiri H, Luo Y, Malovini A, Tibollo V, Bellazzi R, Cho K, Ho YL, Tan ALM, Tan BWL, Gehlenborg N, Lozano-Zahonero S, Jouhet V, Chiovato L, Aronow BJ, Toh EMS, Wong WGS, Pizzimenti S, Wagholikar KB, Bucalo M, Cai T, South AM, Kohane IS, Weber GM.
NPJ Digit Med 2022-06-29
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Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations.

Authors: Ge T, Irvin MR, Patki A, Srinivasasainagendra V, Lin YF, Tiwari HK, Armstrong ND, Benoit B, Chen CY, Choi KW, Cimino JJ, Davis BH, Dikilitas O, Etheridge B, Feng YA, Gainer V, Huang H, Jarvik GP, Kachulis C, Kenny EE, Khan A, Kiryluk K, Kottyan L, Kullo IJ, Lange C, Lennon N, Leong A, Malolepsza E, Miles AD, Murphy S, Namjou B, Narayan R, O'Connor MJ, Pacheco JA, Perez E, Rasmussen-Torvik LJ, Rosenthal EA, Schaid D, Stamou M, Udler MS, Wei WQ, Weiss ST, Ng MCY, Smoller JW, Lebo MS, Meigs JB, Limdi NA, Karlson EW.
Genome Med 2022-06-29
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Changes in laboratory value improvement and mortality rates over the course of the pandemic: an international retrospective cohort study of hospitalised patients infected with SARS-CoV-2.

Authors: Hong C, Zhang HG, L'Yi S, Weber G, Avillach P, Tan BWQ, Gutiérrez-Sacristán A, Bonzel CL, Palmer NP, Malovini A, Tibollo V, Luo Y, Hutch MR, Liu M, Bourgeois F, Bellazzi R, Chiovato L, Sanz Vidorreta FJ, Le TT, Wang X, Yuan W, Neuraz A, Benoit V, Moal B, Morris M, Hanauer DA, Maidlow S, Wagholikar K, Murphy S, Estiri H, Makoudjou A, Tippmann P, Klann J, Follett RW, Gehlenborg N, Omenn GS, Xia Z, Dagliati A, Visweswaran S, Patel LP, Mowery DL, Schriver ER, Samayamuthu MJ, Kavuluru R, Lozano-Zahonero S, Zöller D, Tan ALM, Tan BWL, Ngiam KY, Holmes JH, Schubert P, Cho K, Ho YL, Beaulieu-Jones BK, Pedrera-Jiménez M, García-Barrio N, Serrano-Balazote P, Kohane I, South A, Brat GA, Cai T.
BMJ Open 2022-06-23
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International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality.

Authors: Weber GM, Hong C, Xia Z, Palmer NP, Avillach P, L'Yi S, Keller MS, Murphy SN, Gutiérrez-Sacristán A, Bonzel CL, Serret-Larmande A, Neuraz A, Omenn GS, Visweswaran S, Klann JG, South AM, Loh NHW, Cannataro M, Beaulieu-Jones BK, Bellazzi R, Agapito G, Alessiani M, Aronow BJ, Bell DS, Benoit V, Bourgeois FT, Chiovato L, Cho K, Dagliati A, DuVall SL, Barrio NG, Hanauer DA, Ho YL, Holmes JH, Issitt RW, Liu M, Luo Y, Lynch KE, Maidlow SE, Malovini A, Mandl KD, Mao C, Matheny ME, Moore JH, Morris JS, Morris M, Mowery DL, Ngiam KY, Patel LP, Pedrera-Jimenez M, Ramoni RB, Schriver ER, Schubert P, Balazote PS, Spiridou A, Tan ALM, Tan BWL, Tibollo V, Torti C, Trecarichi EM, Wang X, Kohane IS, Cai T, Brat GA.
NPJ Digit Med 2022-06-13
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Distinguishing Admissions Specifically for COVID-19 From Incidental SARS-CoV-2 Admissions: National Retrospective Electronic Health Record Study.

Authors: Klann JG, Strasser ZH, Hutch MR, Kennedy CJ, Marwaha JS, Morris M, Samayamuthu MJ, Pfaff AC, Estiri H, South AM, Weber GM, Yuan W, Avillach P, Wagholikar KB, Luo Y, Omenn GS, Visweswaran S, Holmes JH, Xia Z, Brat GA, Murphy SN.
J Med Internet Res 2022-05-18
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A framework for employing longitudinally collected multicenter electronic health records to stratify heterogeneous patient populations on disease history.

Authors: Maurits MP, Korsunsky I, Raychaudhuri S, Murphy SN, Smoller JW, Weiss ST, Huizinga TWJ, Reinders MJT, Karlson EW, van den Akker EB, Knevel R.
J Am Med Inform Assoc 2022-04-13
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The Mass General Brigham Biobank Portal: an i2b2-based data repository linking disparate and high-dimensional patient data to support multimodal analytics.

Authors: Castro VM, Gainer V, Wattanasin N, Benoit B, Cagan A, Ghosh B, Goryachev S, Metta R, Park H, Wang D, Mendis M, Rees M, Herrick C, Murphy SN.
J Am Med Inform Assoc 2022-03-15
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