Soumya Raychaudhuri, M.D., Ph.D.

Soumya Raychaudhuri, MD, PhD

Professor of Medicine, Brigham and Women's Hospital
Professor of Biomedical Informatics, Harvard Medical School (Secondary)
Visiting Professor in Genetics, University of Manchester

Soumya Raychaudhuri serves as the Director for the Center for Data Sciences (BWH, HMS) and is appointed as an Associate Member at the Broad Institute. Additionally he is clinically active and sees patients at Brigham and Women’s Hospital Arthritis Center. After completing his MD/PhD at Stanford University, Raychaudhuri pursued clinical training in internal medicine, and then went on to pursue subspecialty training in rheumatology at Brigham and Women’s Hospital. He concurrently completed postdoctoral training in human genetics at the Broad Institute with Dr. Mark Daly. Since joining the faculty at Harvard Medical School in 2010, he has contributed to the understanding of the genetic basis of rheumatoid arthritis and other immune-mediated diseases. He has also been at the forefront of devising statistical and computational methods to localize genetic association signals to causal variants, and to interpret human genetic data in the context of functional information. He currently has active research programs in the human genetics and functional genomics of tuberculosis, type I diabetes, and rheumatoid arthritis, with a specific focus on using genomic strategies to understand CD4+ T cell biology.

Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis.
Authors: Luo Y, Huang CC, Howard NC, Wang X, Liu Q, Li X, Zhu J, Amariuta T, Asgari S, Ishigaki K, Calderon R, Raman S, Ramnarine AK, Mayfield JA, Moody DB, Lecca L, Fortune SM, Murray MB, Raychaudhuri S.
Nat Commun
View full abstract on Pubmed
Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis.
Authors: Faust HJ, Cheng TY, Korsunsky I, Watts GFM, Gal-Oz ST, Trim WV, Kongthong S, Jonsson AH, Simmons DP, Zhang F, Padera R, Chubinskaya S, Wei K, Raychaudhuri S, Lynch L, Moody DB, Brenner MB.
Nat Commun
View full abstract on Pubmed
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease.
Authors: Thomas T, Friedrich M, Rich-Griffin C, Pohin M, Agarwal D, Pakpoor J, Lee C, Tandon R, Rendek A, Aschenbrenner D, Jainarayanan A, Voda A, Siu JHY, Sanches-Peres R, Nee E, Sathananthan D, Kotliar D, Todd P, Kiourlappou M, Gartner L, Ilott N, Issa F, Hester J, Turner J, Nayar S, Mackerodt J, Zhang F, Jonsson A, Brenner M, Raychaudhuri S, Kulicke R, Ramsdell D, Stransky N, Pagliarini R, Bielecki P, Spies N, Marsden B, Taylor S, Wagner A, Klenerman P, Walsh A, Coles M, Jostins-Dean L, Powrie FM, Filer A, Travis S, Uhlig HH, Dendrou CA, Buckley CD.
Nat Immunol
View full abstract on Pubmed
Genomic and Serological Rheumatoid Arthritis Biomarkers, MUC5B Promoter Variant, and Interstitial Lung Abnormalities.
Authors: Kim JS, Flack KF, Malik V, Manichaikul A, Sakaue S, Luo Y, McGroder CF, Salvatore M, Anderson MR, Hoffman EA, Podolanczuk AJ, Yun JH, McDermott GC, Sparks JA, Putman R, Moll M, Rich SS, Rotter JI, Noth I, Raghu G, Giles JT, Winchester R, Raychaudhuri S, Hunninghake GM, Cho MH, Garcia CK, Barr RG, Bernstein EJ.
Ann Am Thorac Soc
View full abstract on Pubmed
Identifying genetic variants that influence the abundance of cell states in single-cell data.
Authors: Rumker L, Sakaue S, Reshef Y, Kang JB, Yazar S, Alquicira-Hernandez J, Valencia C, Lagattuta KA, Mah-Som A, Nathan A, Powell JE, Loh PR, Raychaudhuri S.
Nat Genet
View full abstract on Pubmed
The influence of HLA genetic variation on plasma protein expression.
Authors: Krishna C, Chiou J, Sakaue S, Kang JB, Christensen SM, Lee I, Aksit MA, Kim HI, von Schack D, Raychaudhuri S, Ziemek D, Hu X.
Nat Commun
View full abstract on Pubmed
Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium.
Authors: Dunlap G, Wagner A, Meednu N, Wang R, Zhang F, Ekabe JC, Jonsson AH, Wei K, Sakaue S, Nathan A, Bykerk VP, Donlin LT, Goodman SM, Firestein GS, Boyle DL, Holers VM, Moreland LW, Tabechian D, Pitzalis C, Filer A, Raychaudhuri S, Brenner MB, Thakar J, McDavid A, Rao DA, Anolik JH.
Nat Commun
View full abstract on Pubmed
History of tuberculosis disease is associated with genetic regulatory variation in Peruvians.
Authors: Nieto-Caballero VE, Reijneveld JF, Ruvalcaba A, Innocenzi G, Abeydeera N, Asgari S, Lopez K, Iwany SK, Luo Y, Nathan A, Fernandez-Salinas D, Chiñas M, Huang CC, Zhang Z, León SR, Calderon RI, Lecca L, Budzik JM, Murray M, Van Rhijn I, Raychaudhuri S, Moody DB, Suliman S, Gutierrez-Arcelus M.
PLoS Genet
View full abstract on Pubmed
The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis.
Authors: Weinand K, Sakaue S, Nathan A, Jonsson AH, Zhang F, Watts GFM, Al Suqri M, Zhu Z, Rao DA, Anolik JH, Brenner MB, Donlin LT, Wei K, Raychaudhuri S.
Nat Commun
View full abstract on Pubmed
Granzyme K drives a newly-intentified pathway of complement activation.
Authors: Donado CA, Jonsson AH, Theisen E, Zhang F, Nathan A, Rupani KV, Jones D, Raychaudhuri S, Dwyer DF, Brenner MB.
bioRxiv
View full abstract on Pubmed