Soumya Raychaudhuri, M.D., Ph.D.

Soumya Raychaudhuri, MD, PhD

Professor of Medicine, Brigham and Women's Hospital
Professor of Biomedical Informatics, Harvard Medical School (Secondary)
Visiting Professor in Genetics, University of Manchester

Soumya Raychaudhuri serves as the Director for the Center for Data Sciences (BWH, HMS) and is appointed as an Associate Member at the Broad Institute. Additionally he is clinically active and sees patients at Brigham and Women’s Hospital Arthritis Center. After completing his MD/PhD at Stanford University, Raychaudhuri pursued clinical training in internal medicine, and then went on to pursue subspecialty training in rheumatology at Brigham and Women’s Hospital. He concurrently completed postdoctoral training in human genetics at the Broad Institute with Dr. Mark Daly. Since joining the faculty at Harvard Medical School in 2010, he has contributed to the understanding of the genetic basis of rheumatoid arthritis and other immune-mediated diseases. He has also been at the forefront of devising statistical and computational methods to localize genetic association signals to causal variants, and to interpret human genetic data in the context of functional information. He currently has active research programs in the human genetics and functional genomics of tuberculosis, type I diabetes, and rheumatoid arthritis, with a specific focus on using genomic strategies to understand CD4+ T cell biology.

Fc?R engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity.
Authors: Mysore V, Cullere X, Mears J, Rosetti F, Okubo K, Liew PX, Zhang F, Madera-Salcedo I, Rosenbauer F, Stone RM, Aster JC, von Andrian UH, Lichtman AH, Raychaudhuri S, Mayadas TN.
Nat Commun
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Medical Records-Based Genetic Studies of the Complement System.
Authors: Khan A, Shang N, Petukhova L, Zhang J, Shen Y, Hebbring SJ, Moncrieffe H, Kottyan LC, Namjou-Khales B, Knevel R, Raychaudhuri S, Karlson EW, Harley JB, Stanaway IB, Crosslin D, Denny JC, Elkind MSV, Gharavi AG, Hripcsak G, Weng C, Kiryluk K.
J Am Soc Nephrol
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Genome editing to define the function of risk loci and variants in rheumatic disease.
Authors: Baglaenko Y, Macfarlane D, Marson A, Nigrovic PA, Raychaudhuri S.
Nat Rev Rheumatol
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The Power of Systems Biology: Insights on Lupus Nephritis from the Accelerating Medicines Partnership.
Authors: Fava A, Raychaudhuri S, Rao DA.
Rheum Dis Clin North Am
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Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations.
Authors: Luo Y, Li X, Wang X, Gazal S, Mercader JM, Neale BM, Florez JC, Auton A, Price AL, Finucane HK, Raychaudhuri S.
Hum Mol Genet
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Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease.
Authors: Nathan A, Beynor JI, Baglaenko Y, Suliman S, Ishigaki K, Asgari S, Huang CC, Luo Y, Zhang Z, Lopez K, Lindestam Arlehamn CS, Ernst JD, Jimenez J, Calderón RI, Lecca L, Van Rhijn I, Moody DB, Murray MB, Raychaudhuri S.
Nat Immunol
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Transethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals not only shared but also ethnicity-specific disease associations.
Authors: Degenhardt F, Mayr G, Wendorff M, Boucher G, Ellinghaus E, Ellinghaus D, ElAbd H, Rosati E, Hübenthal M, Juzenas S, Abedian S, Vahedi H, Thelma BK, Yang SK, Ye BD, Cheon JH, Datta LW, Daryani NE, Ellul P, Esaki M, Fuyuno Y, McGovern DPB, Haritunians T, Hong M, Juyal G, Jung ES, Kubo M, Kugathasan S, Lenz TL, Leslie S, Malekzadeh R, Midha V, Motyer A, Ng SC, Okou DT, Raychaudhuri S, Schembri J, Schreiber S, Song K, Sood A, Takahashi A, Torres EA, Umeno J, Alizadeh BZ, Weersma RK, Wong SH, Yamazaki K, Karlsen TH, Rioux JD, Brant SR, Franke A.
Hum Mol Genet
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HATK: HLA analysis toolkit.
Authors: Choi W, Luo Y, Raychaudhuri S, Han B.
Bioinformatics
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IFN-? and TNF-a drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation.
Authors: Zhang F, Mears JR, Shakib L, Beynor JI, Shanaj S, Korsunsky I, Nathan A, Donlin LT, Raychaudhuri S.
Genome Med
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Accurate imputation of human leukocyte antigens with CookHLA.
Authors: Cook S, Choi W, Lim H, Luo Y, Kim K, Jia X, Raychaudhuri S, Han B.
Nat Commun
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