Andreas A. Werdich, Ph.D.

Andreas Werdich, PhD

Director of AI and Data Science, Core for Computational Biomedicine

Andreas Werdich is a physicist who received a Diploma in atomic physics from Freiburg University, Germany, and a PhD in physics from Vanderbilt University. His dissertation was focused on studying the molecular mechanisms of cardiac arrhythmias using high-speed fluorescence imaging of single cells in microfluidic devices. Dr. Werdich completed postdoctoral fellowships at Massachusetts General Hospital and Case Western Reserve University and in 2015, joined the faculty of Harvard Medical School at Brigham Women’s Hospital. Since then, he has been specializing in data science and computer vision, using deep learning techniques to uncover attributes of human health and disease in experimental and clinical data. As the head of the AI and Data Science team at the Core for Computational Biomedicine, Dr. Werdich enjoys helping his colleagues at Harvard Medical School to bridge the gaps between medicine, biomedical engineering and data science. He continues to work in the areas of cardiac electrophysiology and arrhythmias through collaborations with Harvard teaching hospitals.

Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy.
Authors: De Jong HN, Dewey FE, Cordero P, Victorio RA, Kirillova A, Huang Y, Madhvani R, Seo K, Werdich AA, Lan F, Orcholski M, Liu WR, Erbilgin A, Wheeler MT, Chen R, Pan S, Kim YM, Bommakanti K, Marcou CA, Bos JM, Haddad F, Ackerman M, Vasan RS, MacRae C, Wu JC, de Jesus Perez V, Snyder M, Parikh VN, Ashley EA.
Circ Genom Precis Med
View full abstract on Pubmed
Rapid Zebrafish Behavioral Profiling Assay Accelerates the Identification of Environmental Neurodevelopmental Toxicants.
Authors: Zhang K, Liang J, Brun NR, Zhao Y, Werdich AA.
Environ Sci Technol
View full abstract on Pubmed
Ibuprofen and diclofenac impair the cardiovascular development of zebrafish (Danio rerio) at low concentrations.
Authors: Zhang K, Yuan G, Werdich AA, Zhao Y.
Environ Pollut
View full abstract on Pubmed
Metastable Atrial State Underlies the Primary Genetic Substrate for MYL4 Mutation-Associated Atrial Fibrillation.
Authors: Ghazizadeh Z, Kiviniemi T, Olafsson S, Plotnick D, Beerens ME, Zhang K, Gillon L, Steinbaugh MJ, Barrera V, Sui SH, Werdich AA, Kapur S, Eranti A, Gunn J, Jalkanen J, Airaksinen J, Kleber AG, Hollmén M, MacRae CA.
Circulation
View full abstract on Pubmed
LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor) Regulates Cardiac L-Type Calcium Channels by Modulating NEDD (Neural Precursor Cell Expressed Developmentally Downregulated Protein) 4-1 Ubiquitin Ligase.
Authors: Moshal KS, Roder K, Kabakov AY, Werdich AA, Chiang DY, Turan NN, Xie A, Kim TY, Cooper LL, Lu Y, Zhong M, Li W, Terentyev D, Choi BR, Karma A, MacRae CA, Koren G.
Circ Genom Precis Med
View full abstract on Pubmed
Nkx genes establish second heart field cardiomyocyte progenitors at the arterial pole and pattern the venous pole through Isl1 repression.
Authors: Colombo S, de Sena-Tomás C, George V, Werdich AA, Kapur S, MacRae CA, Targoff KL.
Development
View full abstract on Pubmed
Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk.
Authors: Nikolova-Krstevski V, Wagner S, Yu ZY, Cox CD, Cvetkovska J, Hill AP, Huttner IG, Benson V, Werdich AA, MacRae C, Feneley MP, Friedrich O, Martinac B, Fatkin D.
JACC Basic Transl Sci
View full abstract on Pubmed
An infrared optical pacing system for screening cardiac electrophysiology in human cardiomyocytes.
Authors: McPheeters MT, Wang YT, Werdich AA, Jenkins MW, Laurita KR.
PLoS One
View full abstract on Pubmed
Phosphorylation at Connexin43 Serine-368 Is Necessary for Myocardial Conduction During Metabolic Stress.
Authors: Nassal MM, Werdich AA, Wan X, Hoshi M, Deschênes I, Rosenbaum DS, Donahue JK.
J Cardiovasc Electrophysiol
View full abstract on Pubmed
Chamber identity programs drive early functional partitioning of the heart.
Authors: Mosimann C, Panáková D, Werdich AA, Musso G, Burger A, Lawson KL, Carr LA, Nevis KR, Sabeh MK, Zhou Y, Davidson AJ, DiBiase A, Burns CE, Burns CG, MacRae CA, Zon LI.
Nat Commun
View full abstract on Pubmed