Andreas A. Werdich, Ph.D.

Andreas Werdich, PhD

Director of AI and Data Science, Core for Computational Biomedicine

Andreas Werdich is a physicist who received a Diploma in atomic physics from Freiburg University, Germany, and a PhD in physics from Vanderbilt University. His dissertation was focused on studying the molecular mechanisms of cardiac arrhythmias using high-speed fluorescence imaging of single cells in microfluidic devices. Dr. Werdich completed postdoctoral fellowships at Massachusetts General Hospital and Case Western Reserve University and in 2015, joined the faculty of Harvard Medical School at Brigham Women’s Hospital. Since then, he has been specializing in data science and computer vision, using deep learning techniques to uncover attributes of human health and disease in experimental and clinical data. As the head of the AI and Data Science team at the Core for Computational Biomedicine, Dr. Werdich enjoys helping his colleagues at Harvard Medical School to bridge the gaps between medicine, biomedical engineering and data science. He continues to work in the areas of cardiac electrophysiology and arrhythmias through collaborations with Harvard teaching hospitals.

Mapping conduction velocity of early embryonic hearts with a robust fitting algorithm.
Authors: Gu S, Wang YT, Ma P, Werdich AA, Rollins AM, Jenkins MW.
Biomed Opt Express
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RING finger protein RNF207, a novel regulator of cardiac excitation.
Authors: Roder K, Werdich AA, Li W, Liu M, Kim TY, Organ-Darling LE, Moshal KS, Hwang JM, Lu Y, Choi BR, MacRae CA, Koren G.
J Biol Chem
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Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy.
Authors: Arndt AK, Schafer S, Drenckhahn JD, Sabeh MK, Plovie ER, Caliebe A, Klopocki E, Musso G, Werdich AA, Kalwa H, Heinig M, Padera RF, Wassilew K, Bluhm J, Harnack C, Martitz J, Barton PJ, Greutmann M, Berger F, Hubner N, Siebert R, Kramer HH, Cook SA, MacRae CA, Klaassen S.
Am J Hum Genet
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Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure.
Authors: Nath AK, Roberts LD, Liu Y, Mahon SB, Kim S, Ryu JH, Werdich A, Januzzi JL, Boss GR, Rockwood GA, MacRae CA, Brenner M, Gerszten RE, Peterson RT.
FASEB J
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The zebrafish as a novel animal model to study the molecular mechanisms of mechano-electrical feedback in the heart.
Authors: Werdich AA, Brzezinski A, Jeyaraj D, Khaled Sabeh M, Ficker E, Wan X, McDermott BM, Macrae CA, Rosenbaum DS.
Prog Biophys Mol Biol
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Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture.
Authors: Feinberg AW, Alford PW, Jin H, Ripplinger CM, Werdich AA, Sheehy SP, Grosberg A, Parker KK.
Biomaterials
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Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish.
Authors: Wythe JD, Jurynec MJ, Urness LD, Jones CA, Sabeh MK, Werdich AA, Sato M, Yost HJ, Grunwald DJ, Macrae CA, Li DY.
Dis Model Mech
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The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion.
Authors: Wang J, Panáková D, Kikuchi K, Holdway JE, Gemberling M, Burris JS, Singh SP, Dickson AL, Lin YF, Sabeh MK, Werdich AA, Yelon D, Macrae CA, Poss KD.
Development
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Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish.
Authors: Becker JR, Deo RC, Werdich AA, Panàkovà D, Coy S, MacRae CA.
Dis Model Mech
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Hierarchical architecture influences calcium dynamics in engineered cardiac muscle.
Authors: Pong T, Adams WJ, Bray MA, Feinberg AW, Sheehy SP, Werdich AA, Parker KK.
Exp Biol Med (Maywood)
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