Ofer Isakov

Ofer Isakov, MD, PhD

Berkowitz Family Living Laboratory Postdoctoral Research Fellow

Ofer Isakov is a physician-scientist with a specialty in internal medicine. Ofer is a graduate of the MD/PhD program in Tel Aviv University. His doctoral dissertation focused on the development and application of bioinformatics tools to study human and microbial genomics. During his residency, Ofer led a bioinformatics lab at the Tel Aviv Medical Center, which focused on applying machine learning methods to study clinical questions. Ofer serves as the head of bioinformatics at the genomics center in Clalit. His responsibilities include conception, incorporation and validation of the methods, tools and infrastructure required for analysis of genomic data. Ofer’s research interests include rare genetic disease diagnosis, characterization of genotype-phenotype associations and development of novel genomic data science methods.

Variant PADI3 in Central Centrifugal Cicatricial Alopecia.
Authors: Malki L, Sarig O, Romano MT, Méchin MC, Peled A, Pavlovsky M, Warshauer E, Samuelov L, Uwakwe L, Briskin V, Mohamad J, Gat A, Isakov O, Rabinowitz T, Shomron N, Adir N, Simon M, McMichael A, Dlova NC, Betz RC, Sprecher E.
N Engl J Med
View full abstract on Pubmed
Genotype-Serotype Interactions Shed Light on Genetic Components of Inflammatory Bowel Diseases.
Authors: Ben-Shachar S, Finezilber Y, Elad H, Rabinowitz K, Goren I, Isakov O, Yanai H, Dotan I.
Inflamm Bowel Dis
View full abstract on Pubmed
HIV-1 infection increases microRNAs that inhibit Dicer1, HRB and HIV-EP2, thereby reducing viral replication.
Authors: Modai S, Farberov L, Herzig E, Isakov O, Hizi A, Shomron N.
PLoS One
View full abstract on Pubmed
Exhaustive non-synonymous variants functionality prediction enables high resolution characterization of the neurofibromin architecture.
Authors: Isakov O, Wallis D, Evans DG, Ben-Shachar S.
EBioMedicine
View full abstract on Pubmed
Neoadjuvant FOLFIRINOX for locally advanced and borderline resectable pancreatic cancer: An intention to treat analysis.
Authors: Barenboim A, Lahat G, Geva R, Nachmany I, Nakache R, Goykhman Y, Brazowski E, Rosen G, Isakov O, Wolf I, Klausner JM, Lubezky N.
Eur J Surg Oncol
View full abstract on Pubmed
Corrigendum to "X-linked elliptocytosis with impaired growth is related to mutated AMMECR1" [Gene 606C (2017) 47-52].
Authors: Basel-Vanagaite L, Pillar N, Isakov O, Smirin-Yosef P, Lagovsky I, Orenstein N, Salmon-Divon M, Tamary H, Zaft T, Bazak L, Meyerovitch J, Pelli T, Botchan S, Farberov L, Weissglas-Volkov D, Shomron N.
Gene
View full abstract on Pubmed
Seasonal Genetic Drift of Human Influenza A Virus Quasispecies Revealed by Deep Sequencing.
Authors: Barbezange C, Jones L, Blanc H, Isakov O, Celniker G, Enouf V, Shomron N, Vignuzzi M, van der Werf S.
Front Microbiol
View full abstract on Pubmed
Machine Learning-Based Gene Prioritization Identifies Novel Candidate Risk Genes for Inflammatory Bowel Disease.
Authors: Isakov O, Dotan I, Ben-Shachar S.
Inflamm Bowel Dis
View full abstract on Pubmed
Epidermolytic Ichthyosis Sine Epidermolysis.
Authors: Eskin-Schwartz M, Drozhdina M, Sarig O, Gat A, Jackman T, Isakov O, Shomron N, Samuelov L, Malchin N, Peled A, Vodo D, Hovnanian A, Ruzicka T, Koshkin S, Harmon RM, Koetsier JL, Green KJ, Paller AS, Sprecher E.
Am J Dermatopathol
View full abstract on Pubmed
X-linked elliptocytosis with impaired growth is related to mutated AMMECR1.
Authors: Basel-Vanagaite L, Pillar N, Isakov O, Smirin-Yosef P, Lagovsky I, Orenstein N, Salmon-Divon M, Tamary H, Zaft T, Bazak L, Meyerovitch J, Pelli T, Botchan S, Farberov L, Weissglas-Volkov D, Shomron N.
Gene
View full abstract on Pubmed