Ofer Isakov

Ofer Isakov, MD, PhD

Berkowitz Family Living Laboratory Postdoctoral Research Fellow

Ofer Isakov is a physician-scientist with a specialty in internal medicine. Ofer is a graduate of the MD/PhD program in Tel Aviv University. His doctoral dissertation focused on the development and application of bioinformatics tools to study human and microbial genomics. During his residency, Ofer led a bioinformatics lab at the Tel Aviv Medical Center, which focused on applying machine learning methods to study clinical questions. Ofer serves as the head of bioinformatics at the genomics center in Clalit. His responsibilities include conception, incorporation and validation of the methods, tools and infrastructure required for analysis of genomic data. Ofer’s research interests include rare genetic disease diagnosis, characterization of genotype-phenotype associations and development of novel genomic data science methods.

Calpain 12 Function Revealed through the Study of an Atypical Case of Autosomal Recessive Congenital Ichthyosis.
Authors: Bochner R, Samuelov L, Sarig O, Li Q, Adase CA, Isakov O, Malchin N, Vodo D, Shayevitch R, Peled A, Yu BD, Fainberg G, Warshauer E, Adir N, Erez N, Gat A, Gottlieb Y, Rogers T, Pavlovsky M, Goldberg I, Shomron N, Sandilands A, Campbell LE, MacCallum S, McLean WHI, Ast G, Gallo RL, Uitto J, Sprecher E.
J Invest Dermatol
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Whole-exome sequencing in individuals with multiple cardiovascular risk factors and normal coronary arteries.
Authors: Abramowitz Y, Roth A, Keren G, Isakov O, Shomron N, Laitman Y, Weissglas-Volkov D, Arbel Y, Banai S, Finkelstein A, Friedman E.
Coron Artery Dis
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Influence of population diversity on neurovirulence potential of plaque purified L-Zagreb variants.
Authors: Ivancic-Jelecki J, Forcic D, Jagusic M, Kosutic-Gulija T, Mazuran R, Balija ML, Isakov O, Shomron N.
Vaccine
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Whole-Genome Sequencing Analysis from the Chikungunya Virus Caribbean Outbreak Reveals Novel Evolutionary Genomic Elements.
Authors: Stapleford KA, Moratorio G, Henningsson R, Chen R, Matheus S, Enfissi A, Weissglas-Volkov D, Isakov O, Blanc H, Mounce BC, Dupont-Rouzeyrol M, Shomron N, Weaver S, Fontes M, Rousset D, Vignuzzi M.
PLoS Negl Trop Dis
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Correction: MicroRNAs Expression in the Ileal Pouch of Patients with Ulcerative Colitis Is Robustly Up-Regulated and Correlates with Disease Phenotypes.
Authors: Ben-Shachar S, Yanai H, Sherman Horev H, Elad H, Baram L, Isakov O, Tulchinsky H, Pasmanik-Chor M, Shomron N, Dotan I.
PLoS One
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Actionable clinical decisions based on comprehensive genomic evaluation in asymptomatic adults.
Authors: Pillar N, Isakov O, Weissglas-Volkov D, Botchan S, Friedman E, Arber N, Shomron N.
Mol Genet Genomic Med
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Deep sequencing analysis of viral infection and evolution allows rapid and detailed characterization of viral mutant spectrum.
Authors: Isakov O, Bordería AV, Golan D, Hamenahem A, Celniker G, Yoffe L, Blanc H, Vignuzzi M, Shomron N.
Bioinformatics
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Rare genetic variants in Tunisian Jewish patients suffering from age-related macular degeneration.
Authors: Pras E, Kristal D, Shoshany N, Volodarsky D, Vulih I, Celniker G, Isakov O, Shomron N, Pras E.
J Med Genet
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Non-syndromic retinitis pigmentosa due to mutations in the mucopolysaccharidosis type IIIC gene, heparan-alpha-glucosaminide N-acetyltransferase (HGSNAT).
Authors: Haer-Wigman L, Newman H, Leibu R, Bax NM, Baris HN, Rizel L, Banin E, Massarweh A, Roosing S, Lefeber DJ, Zonneveld-Vrieling MN, Isakov O, Shomron N, Sharon D, Den Hollander AI, Hoyng CB, Cremers FP, Ben-Yosef T.
Hum Mol Genet
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Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelity.
Authors: Smith EC, Case JB, Blanc H, Isakov O, Shomron N, Vignuzzi M, Denison MR.
J Virol
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