Peter Park

Peter Park, PhD

Professor of Biomedical Informatics
Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street, Boston, MA 02115

Park Lab

Dr. Park is a Professor of Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics PhD program. His research group specializes in computational and statistical analysis of large-scale DNA sequencing data to understand genetic and epigenetic mechanisms related to disease processes. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for identifying and interpreting genomic alterations in the human genome, especially those from cancer patients. His group has made major contributions to many consortium projects such as The Cancer Genome Atlas (TCGA), Encyclopedia of DNA Elements (ENCODE), and Brain Somatic Mosaicism Network, and 4D Nucleome, and Somatic Mosaicism across Human Tissues (SMaHT). His work has been funded by the National Institutes of Health, Cancer Research UK Grand Challenges, The Mark Foundation for Cancer Research, Simons Foundation, Chan Zucherberg Initiative, Blavatnik Therapeutics Challenge, the HMS Quadrangle Fund for Advancing and Seeding Translational Research (Q-FASTR), and others.


DBMI Research Areas
DBMI Courses
Retraction notice to "Efficacy of Sunitinib and Radiotherapy in Genetically Engineered Mouse Model of Soft-Tissue Sarcoma" Int J Radiat Oncol Biol Phys, 2009; 74(4), pp 1207-1216.
Authors: Yoon SS, Stangenberg L, Lee YJ, Rothrock C, Dreyfuss JM, Baek KH, Waterman PR, Nielsen GP, Weissleder R, Mahmood U, Park PJ, Jacks T, Dodd RD, Fisher CJ, Ryeom S, Kirsch DG.
Int J Radiat Oncol Biol Phys
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Pilot Study of Early Catheter Ablation and Neurological Outcomes in Atrial Fibrillation-Related Stroke: RESCUE-STROKE.
Authors: Katapadi A, Garg J, Chelikam N, Bommana S, DiBiase L, Atkins D, Kabra R, Darden D, Park P, Pothineni NVK, Albadareen R, Kazi S, Gopinathannair R, Natale A, Lakkireddy D.
JACC Clin Electrophysiol
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GoMartini 3: From large conformational changes in proteins to environmental bias corrections.
Authors: Souza PCT, Borges-Araújo L, Brasnett C, Moreira RA, Grünewald F, Park P, Wang L, Razmazma H, Borges-Araújo AC, Cofas-Vargas LF, Monticelli L, Mera-Adasme R, Melo MN, Wu S, Marrink SJ, Poma AB, Thallmair S.
Nat Commun
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Gantry-based pencil beam scanning proton therapy for uveal melanoma: IMPT versus proton arc therapy.
Authors: Qi H, Hu L, Huang S, Lee YP, Yu F, Chen Q, Yang Y, Kang M, Zhai H, Vermeulen M, Shim A, Park P, Ding X, Zhou J, Abramson DH, Francis JH, Simone CB, Barker CA, Lin H.
Radiat Oncol
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Recurrent patterns of widespread neuronal genomic damage shared by major neurodegenerative disorders.
Authors: Zhou Z, Luquette LJ, Dong G, Kim J, Ku J, Kim K, Bae M, Shao DD, Sahile B, Miller MB, Huang AY, Nathan WJ, Nussenzweig A, Park PJ, Lagier-Tourenne C, Lee EA, Walsh CA.
bioRxiv
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Pulmonary Artery Injury Following Endocardial Left Atrial Appendage Occlusion: The Known and Unknown.
Authors: Katapadi A, Garg J, Mansabdar A, Chelikam N, Ehteshamuddin F, Rane M, Nair D, Marcum J, Pope T, Park P, Ellis C, Kabra R, Lo M, Atkins D, Saw J, Shah A, Lakkireddy D.
JACC Clin Electrophysiol
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A panel-based mutational signature of homologous recombination deficiency associates with response to PARP inhibition in metastatic castration-resistant prostate cancer.
Authors: Boiarsky D, Tewari AK, Gulhan DC, Bakouny Z, Ananda G, Savignano H, Lakshminarayanan G, McClure HM, Silver R, Choueiri TK, Taplin ME, Park PJ, Berchuck JE.
Prostate
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An integrated view of the structure and function of the human 4D nucleome.
Authors: Dekker J, Oksuz BA, Zhang Y, Wang Y, Minsk MK, Kuang S, Yang L, Gibcus JH, Krietenstein N, Rando OJ, Xu J, Janssens DH, Henikoff S, Kukalev A, Willemin A, Winick-Ng W, Kempfer R, Pombo A, Yu M, Kumar P, Zhang L, Belmont AS, Sasaki T, van Schaik T, Brueckner L, Peric-Hupkes D, van Steensel B, Wang P, Chai H, Kim M, Ruan Y, Zhang R, Quinodoz SA, Bhat P, Guttman M, Zhao W, Chien S, Liu Y, Venev SV, Plewczynski D, Azcarate II, Szabó D, Thieme CJ, Szczepinska T, Chilinski M, Sengupta K, Conte M, Esposito A, Abraham A, Zhang R, Wang Y, Wen X, Wu Q, Yang Y, Liu J, Boninsegna L, Yildirim A, Zhan Y, Chiariello AM, Bianco S, Lee L, Hu M, Li Y, Barnett RJ, Cook AL, Emerson DJ, Marchal C, Zhao P, Park P, Alver BH, Schroeder A, Navelkar R, Bakker C, Ronchetti W, Ehmsen S, Veit A, Gehlenborg N, Wang T, Li D, Wang X, Nicodemi M, Ren B, Zhong S, Phillips-Cremins JE, Gilbert DM, Pollard KS, Alber F, Ma J, Noble WS, Yue F.
bioRxiv
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Somatic mosaicism in schizophrenia brains reveals prenatal mutational processes.
Authors: Maury EA, Jones A, Seplyarskiy V, Nguyen TTL, Rosenbluh C, Bae T, Wang Y, Abyzov A, Khoshkhoo S, Chahine Y, Zhao S, Venkatesh S, Root E, Voloudakis G, Roussos P, Park PJ, Akbarian S, Brennand K, Reilly S, Lee EA, Sunyaev SR, Walsh CA, Chess A.
Science
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Perinatal Reduction of Genetically Aberrant Neurons from Human Cerebral Cortex.
Authors: Shao DD, Zhao Y, Ghosh U, Brew J, Zhao S, Qian X, Tran J, Taketomi T, Tsuruta F, Park PJ, Walsh CA.
bioRxiv
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