Peter Park

Peter Park, PhD

Professor of Biomedical Informatics
Director, Bioinformatics and Integrative Genomics (BIG) PhD Track

10 Shattuck Street, Boston, MA 02115

Dr. Park is a Professor of Biomedical Informatics at Harvard Medical School and the director of its Bioinformatics and Integrative Genomics PhD program. His research group specializes in computational and statistical analysis of large-scale DNA sequencing data to understand genetic and epigenetic mechanisms related to disease processes. Originally trained in applied mathematics (B.A., Harvard; Ph.D., Caltech), he was introduced to molecular biology and genetics during his postdoctoral studies in biostatistics. His laboratory has developed several algorithms for identifying and interpreting genomic alterations in the human genome, especially those from cancer patients. His group has made major contributions to many consortium projects such as The Cancer Genome Atlas (TCGA), Encyclopedia of DNA Elements (ENCODE), and Brain Somatic Mosaicism Network, and 4D Nucleome, and Somatic Mosaicism across Human Tissues (SMaHT). His work has been funded by the National Institutes of Health, Cancer Research UK Grand Challenges, The Mark Foundation for Cancer Research, Simons Foundation, Chan Zucherberg Initiative, Blavatnik Therapeutics Challenge, the HMS Quadrangle Fund for Advancing and Seeding Translational Research (Q-FASTR), and others.


DBMI Research Areas
DBMI Courses
The effect of a local anesthetic cocktail in a serratus anterior plane and PECS 1 block for implant-based breast reconstruction.
Authors: Lombana NF, Beard C, Mehta IM, Falola RA, Park P, Altman AM, Saint-Cyr MH.
JPRAS Open
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Recent Advances in Genomic Approaches for the Detection of Homologous Recombination Deficiency.
Authors: Kim YN, Gulhan DC, Jin H, Glodzik D, Park PJ.
Cancer Res Treat
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Impact of an Organized Treatment Pathway on Management of Atrial Fibrillation: The ER2EP Study.
Authors: Lakkireddy D, Ahmed A, Bawa D, Garg J, Atkins D, Kabra R, Pham N, Bernholtz J, Darden D, Bommana S, Gopinathannair R, Pothineni NVK, Park P, Vasamreddy C, Tummala R, Koerber S, Della Rocca D, DiBiase L, Al-Ahmad A, Natale A.
JACC Adv
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High-resolution detection of copy number alterations in single cells with HiScanner.
Authors: Zhao Y, Luquette LJ, Veit AD, Wang X, Xi R, Viswanadham VV, Shao DD, Walsh CA, Yang HW, Johnson MD, Park PJ.
bioRxiv
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Contribution of de novo retroelements to birth defects and childhood cancers.
Authors: Chu C, Ljungström V, Tran A, Jin H, Park PJ.
medRxiv
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Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes.
Authors: Ganz J, Luquette LJ, Bizzotto S, Miller MB, Zhou Z, Bohrson CL, Jin H, Tran AV, Viswanadham VV, McDonough G, Brown K, Chahine Y, Chhouk B, Galor A, Park PJ, Walsh CA.
Cell
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A Panel-Based Mutational Signature of Mismatch Repair Deficiency is Associated With Durable Response to Pembrolizumab in Metastatic Castration-Resistant Prostate Cancer.
Authors: Boiarsky D, Gulhan DC, Savignano H, Lakshminarayanan G, McClure HM, Silver R, Hirsch MS, Sholl LM, Choudhury AD, Ananda G, Park PJ, Tewari AK, Berchuck JE.
Clin Genitourin Cancer
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Epigenetic profiling reveals key genes and cis-regulatory networks specific to human parathyroids.
Authors: Jung YL, Zhao W, Li I, Jain D, Epstein CB, Bernstein BE, Parangi S, Sherwood R, Robinson-Cohen C, Hsu YH, Park PJ, Mannstadt M.
Nat Commun
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Accurate and sensitive mutational signature analysis with MuSiCal.
Authors: Jin H, Gulhan DC, Geiger B, Ben-Isvy D, Geng D, Ljungström V, Park PJ.
Nat Genet
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Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns.
Authors: Watson EV, Lee JJ, Gulhan DC, Melloni GEM, Venev SV, Magesh RY, Frederick A, Chiba K, Wooten EC, Naxerova K, Dekker J, Park PJ, Elledge SJ.
Nat Genet
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