Dana Vuzman, PhD
Dana Vuzman, PhD
Instructor in Medicine, Brigham and Women's Hospital
Research Associate in Biomedical Informatics, Harvard Medical School

Dana Vuzman is an Instructor of Medicine at Harvard Medical School and the Director of Genomic Platform Development at DBMI. Vuzman oversees the implementation of the Clinical Genome Analysis Platform (CGAP) and the Single Cell RNA Platform in the Department. Prior to joining DBMI, she served as Chief Informatics Officer at One Brave Idea, Sr. Director of Biomedical Informatics at KEW, Inc. and co-Director at Brigham Genomic Medicine. Vuzman earned her PhD in Computational Biology from the Weizmann Institute of Science in Israel and completed her postdoctoral training in Computational Genetics at Brigham and Women’s Hospital and Harvard Medical School.

novoCaller: a Bayesian network approach for de novo variant calling from pedigree and population sequence data.
Authors: Mohanty AK, Vuzman D, Francioli L, Cassa C, Toth-Petroczy A, Sunyaev S.
Bioinformatics
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Dual MAPK Inhibition Is an Effective Therapeutic Strategy for a Subset of Class II BRAF Mutant Melanomas.
Authors: Dankner M, Lajoie M, Moldoveanu D, Nguyen TT, Savage P, Rajkumar S, Huang X, Lvova M, Protopopov A, Vuzman D, Hogg D, Park M, Guiot MC, Petrecca K, Mihalcioiu C, Watson IR, Siegel PM, Rose AAN.
Clin Cancer Res
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An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery.
Authors: Haghighi A, Krier JB, Toth-Petroczy A, Cassa CA, Frank NY, Carmichael N, Fieg E, Bjonnes A, Mohanty A, Briere LC, Lincoln S, Lucia S, Gupta VA, Söylemez O, Sutti S, Kooshesh K, Qiu H, Fay CJ, Perroni V, Valerius J, Hanna M, Frank A, Ouahed J, Snapper SB, Pantazi A, Chopra SS, Leshchiner I, Stitziel NO, Feldweg A, Mannstadt M, Loscalzo J, Sweetser DA, Liao E, Stoler JM, Nowak CB, Sanchez-Lara PA, Klein OD, Perry H, Patsopoulos NA, Raychaudhuri S, Goessling W, Green RC, Seidman CE, MacRae CA, Sunyaev SR, Maas RL, Vuzman D.
NPJ Genom Med
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Actionable gene-based classification toward precision medicine in gastric cancer.
Authors: Ichikawa H, Nagahashi M, Shimada Y, Hanyu T, Ishikawa T, Kameyama H, Kobayashi T, Sakata J, Yabusaki H, Nakagawa S, Sato N, Hirata Y, Kitagawa Y, Tanahashi T, Yoshida K, Nakanishi R, Oki E, Vuzman D, Lyle S, Takabe K, Ling Y, Okuda S, Akazawa K, Wakai T.
Genome Med
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Reply.
Authors: Joseph K, Constantino-Silva RN, Grumach AS, Feldweg A, Wright L, Frank N, Vuzman D, Sharma R, Suffritti C, Cicardi M, Varga L, Farkas H, Bork K, Kaplan AP.
J Allergy Clin Immunol
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Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans.
Authors: Lee VS, Halabi CM, Hoffman EP, Carmichael N, Leshchiner I, Lian CG, Bierhals AJ, Vuzman D, Mecham RP, Frank NY, Stitziel NO.
Proc Natl Acad Sci U S A
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An argument for early genomic sequencing in atypical cases: a WISP3 variant leads to diagnosis of progressive pseudorheumatoid arthropathy of childhood.
Authors: Cassa CA, Smith SE, Docken W, Hoffman E, McLaughlin H, Chun S, Leshchiner I, Miraoui H, Raychaudhuri S, Frank NY, Wilson BJ, Sunyaev SR, Maas RL, Vuzman D.
Rheumatology (Oxford)
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Balancing between affinity and speed in target DNA search by zinc-finger proteins via modulation of dynamic conformational ensemble.
Authors: Zandarashvili L, Esadze A, Vuzman D, Kemme CA, Levy Y, Iwahara J.
Proc Natl Acad Sci U S A
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Inherited CHST11/MIR3922 deletion is associated with a novel recessive syndrome presenting with skeletal malformation and malignant lymphoproliferative disease.
Authors: Chopra SS, Leshchiner I, Duzkale H, McLaughlin H, Giovanni M, Zhang C, Stitziel N, Fingeroth J, Joyce RM, Lebo M, Rehm H, Vuzman D, Maas R, Sunyaev SR, Murray M, Cassa CA.
Mol Genet Genomic Med
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Asymmetrical roles of zinc fingers in dynamic DNA-scanning process by the inducible transcription factor Egr-1.
Authors: Zandarashvili L, Vuzman D, Esadze A, Takayama Y, Sahu D, Levy Y, Iwahara J.
Proc Natl Acad Sci U S A
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