Robert Gentleman

Robert Gentleman, PhD

Executive Director, Center for Computational Biomedicine
Professor of the Practice in the Department of Biomedical Informatics

Robert Gentleman is the founding executive director of Harvard Medical School’s Center for Computational Biomedicine. An accomplished statistician and bioinformatician, Dr. Gentleman is one of the creators of the R programming language and a founder of the Bioconductor project, an open-source collaborative software tool to promote statistical analysis of biological data. He has served as vice president of 23andMe, where he helped launch their therapeutic division, and as senior director for bioinformatics and computational biology at Genentech. He was head of computational biology at the Fred Hutchinson Cancer Research Center and held academic positions at Harvard University, University of Auckland and the University of Waterloo. Dr. Gentleman’s research interests are related to genomics, machine learning, data visualization, and the application of statistical and computational methods to study human disease.

BioPlexR and BioPlexPy: integrated data products for the analysis of human protein interactions.
Authors: Geistlinger L, Vargas R, Lee T, Pan J, Huttlin EL, Gentleman R.
Bioinformatics
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Demographic, spatial and temporal dietary intake patterns among 526 774 23andMe research participants.
Authors: Shelton JF, Cameron B, Aslibekyan S, Gentleman R.
Public Health Nutr
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Disease risk scores for skin cancers.
Authors: Fontanillas P, Alipanahi B, Furlotte NA, Johnson M, Wilson CH, Pitts SJ, Gentleman R, Auton A.
Nat Commun
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Addressing the accuracy of direct-to-consumer genetic testing.
Authors: Wu S, Pollard J, Chowdry A, Scheller R, Gentleman R.
Genet Med
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VariantTools: an extensible framework for developing and testing variant callers.
Authors: Lawrence M, Gentleman R.
Bioinformatics
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Creating a data resource: what will it take to build a medical information commons?
Authors: Deverka PA, Majumder MA, Villanueva AG, Anderson M, Bakker AC, Bardill J, Boerwinkle E, Bubela T, Evans BJ, Garrison NA, Gibbs RA, Gentleman R, Glazer D, Goldstein MM, Greely H, Harris C, Knoppers BM, Koenig BA, Kohane IS, La Rosa S, Mattison J, O'Donnell CJ, Rai AK, Rehm HL, Rodriguez LL, Shelton R, Simoncelli T, Terry SF, Watson MS, Wilbanks J, Cook-Deegan R, McGuire AL.
Genome Med
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Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers.
Authors: Goldstein LD, Lee J, Gnad F, Klijn C, Schaub A, Reeder J, Daemen A, Bakalarski CE, Holcomb T, Shames DS, Hartmaier RJ, Chmielecki J, Seshagiri S, Gentleman R, Stokoe D.
Cell Rep
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Complex regulation of ADAR-mediated RNA-editing across tissues.
Authors: Huntley MA, Lou M, Goldstein LD, Lawrence M, Dijkgraaf GJ, Kaminker JS, Gentleman R.
BMC Genomics
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Prediction and Quantification of Splice Events from RNA-Seq Data.
Authors: Goldstein LD, Cao Y, Pau G, Lawrence M, Wu TD, Seshagiri S, Gentleman R.
PLoS One
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A comprehensive transcriptional portrait of human cancer cell lines.
Authors: Klijn C, Durinck S, Stawiski EW, Haverty PM, Jiang Z, Liu H, Degenhardt J, Mayba O, Gnad F, Liu J, Pau G, Reeder J, Cao Y, Mukhyala K, Selvaraj SK, Yu M, Zynda GJ, Brauer MJ, Wu TD, Gentleman RC, Manning G, Yauch RL, Bourgon R, Stokoe D, Modrusan Z, Neve RM, de Sauvage FJ, Settleman J, Seshagiri S, Zhang Z.
Nat Biotechnol
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