Shamil Sunyaev

Shamil Sunyaev, PhD

Professor of Biomedical Informatics, Harvard Medical School
Professor of Medicine, Brigham and Women’s Hospital

10 Shattuck Street, Room 311A, Boston, MA 02115

Shamil Sunyaev is a computational genomicist and geneticist. Research in his lab encompasses many aspects of population genetic variation including the origin of mutations, the effect of allelic variants on molecular function, population and evolutionary genetics, and genetics of human complex and Mendelian traits. He developed several computational and statistical methods widely adopted by the community. Sunyaev obtained a PhD in molecular biophysics from the Moscow Institute of Physics and Technology and completed his postdoctoral training in bioinformatics at the European Molecular Biology Laboratory (EMBL). He is an Institute Member at Broad Institute of MIT and Harvard. He also co-organizes the Boston Evolutionary Genomics Supergroup.


DBMI Research Areas
DBMI Courses
Development and validation of a computational method for assessment of missense variants in hypertrophic cardiomyopathy.
Authors: Jordan DM, Kiezun A, Baxter SM, Agarwala V, Green RC, Murray MF, Pugh T, Lebo MS, Rehm HL, Funke BH, Sunyaev SR.
Am J Hum Genet
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Pooled association tests for rare variants in exon-resequencing studies.
Authors: Price AL, Kryukov GV, de Bakker PI, Purcell SM, Staples J, Wei LJ, Sunyaev SR.
Am J Hum Genet
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Human allelic variation: perspective from protein function, structure, and evolution.
Authors: Jordan DM, Ramensky VE, Sunyaev SR.
Curr Opin Struct Biol
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A method and server for predicting damaging missense mutations.
Authors: Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS, Sunyaev SR.
Nat Methods
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Triplet repeat length bias and variation in the human transcriptome.
Authors: Molla M, Delcher A, Sunyaev S, Cantor C, Kasif S.
Proc Natl Acad Sci U S A
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Multiplex padlock targeted sequencing reveals human hypermutable CpG variations.
Authors: Li JB, Gao Y, Aach J, Zhang K, Kryukov GV, Xie B, Ahlford A, Yoon JK, Rosenbaum AM, Zaranek AW, LeProust E, Sunyaev SR, Church GM.
Genome Res
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Human mutation rate associated with DNA replication timing.
Authors: Stamatoyannopoulos JA, Adzhubei I, Thurman RE, Kryukov GV, Mirkin SM, Sunyaev SR.
Nat Genet
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Power of deep, all-exon resequencing for discovery of human trait genes.
Authors: Kryukov GV, Shpunt A, Stamatoyannopoulos JA, Sunyaev SR.
Proc Natl Acad Sci U S A
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Adaptive mutations in the JC virus protein capsid are associated with progressive multifocal leukoencephalopathy (PML).
Authors: Sunyaev SR, Lugovskoy A, Simon K, Gorelik L.
PLoS Genet
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SNP2RFLP: a computational tool to facilitate genetic mapping using benchtop analysis of SNPs.
Authors: Beckstead WA, Bjork BC, Stottmann RW, Sunyaev S, Beier DR.
Mamm Genome
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