Shamil Sunyaev

Shamil Sunyaev, PhD

Professor of Biomedical Informatics, Harvard Medical School
Professor of Medicine, Brigham and Women’s Hospital

10 Shattuck Street, Room 311A, Boston, MA 02115

Shamil Sunyaev is a computational genomicist and geneticist. Research in his lab encompasses many aspects of population genetic variation including the origin of mutations, the effect of allelic variants on molecular function, population and evolutionary genetics, and genetics of human complex and Mendelian traits. He developed several computational and statistical methods widely adopted by the community. Sunyaev obtained a PhD in molecular biophysics from the Moscow Institute of Physics and Technology and completed his postdoctoral training in bioinformatics at the European Molecular Biology Laboratory (EMBL). He is an Institute Member at Broad Institute of MIT and Harvard. He also co-organizes the Boston Evolutionary Genomics Supergroup.


DBMI Research Areas
DBMI Courses
Erratum.
Authors: Schmidt S, Gerasimova A, Kondrashov FA, Adzhubei IA, Kondrashov AS, Sunyaev S.
PLoS Genet
View full abstract on Pubmed
Hypermutable non-synonymous sites are under stronger negative selection.
Authors: Schmidt S, Gerasimova A, Kondrashov FA, Adzhubei IA, Adzuhbei IA, Kondrashov AS, Sunyaev S.
PLoS Genet
View full abstract on Pubmed
Protein identification pipeline for the homology-driven proteomics.
Authors: Junqueira M, Spirin V, Balbuena TS, Thomas H, Adzhubei I, Sunyaev S, Shevchenko A.
J Proteomics
View full abstract on Pubmed
Separating the wheat from the chaff: unbiased filtering of background tandem mass spectra improves protein identification.
Authors: Junqueira M, Spirin V, Santana Balbuena T, Waridel P, Surendranath V, Kryukov G, Adzhubei I, Thomas H, Sunyaev S, Shevchenko A.
J Proteome Res
View full abstract on Pubmed
Assessing the evolutionary impact of amino acid mutations in the human genome.
Authors: Boyko AR, Williamson SH, Indap AR, Degenhardt JD, Hernandez RD, Lohmueller KE, Adams MD, Schmidt S, Sninsky JJ, Sunyaev SR, White TJ, Nielsen R, Clark AG, Bustamante CD.
PLoS Genet
View full abstract on Pubmed
Proportionally more deleterious genetic variation in European than in African populations.
Authors: Lohmueller KE, Indap AR, Schmidt S, Boyko AR, Hernandez RD, Hubisz MJ, Sninsky JJ, White TJ, Sunyaev SR, Nielsen R, Clark AG, Bustamante CD.
Nature
View full abstract on Pubmed
Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms.
Authors: Gorlov IP, Gorlova OY, Sunyaev SR, Spitz MR, Amos CI.
Am J Hum Genet
View full abstract on Pubmed
Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
Authors: Ballif BA, Carey GR, Sunyaev SR, Gygi SP.
J Proteome Res
View full abstract on Pubmed
Common single-nucleotide polymorphisms act in concert to affect plasma levels of high-density lipoprotein cholesterol.
Authors: Spirin V, Schmidt S, Pertsemlidis A, Cooper RS, Cohen JC, Sunyaev SR.
Am J Hum Genet
View full abstract on Pubmed
Analysis of sequence conservation at nucleotide resolution.
Authors: Asthana S, Roytberg M, Stamatoyannopoulos J, Sunyaev S.
PLoS Comput Biol
View full abstract on Pubmed