Evolutionary and population genetics studies the origin and maintenance of genetic variation in populations, and uncovers molecular mechanisms of adaptation. Computational analysis of massive genomic data for human populations, bacterial pathogens, and cancers informs our understanding of evolution at the molecular level. At the same time, the application of evolutionary principles can guide the surveillance, diagnosis, and even treatment of antibiotic resistance, common human diseases, and cancer progression.


Faculty

News

Damage Control (May 5, 2017)
Natural Selection Against Disease-Causing Mutations in Humans is Ongoing


Publications

Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies (eLIFE, 2019)

Negative selection in humans and fruit flies involves synergistic epistasis (Science, 2017)